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The Aspirin Esomeprazole Chemoprevention Trial (AspECT) is to our knowledge one of the largest cancer prevention trials using aspirin and acid suppression in the world. In total 2557 patients with a common precancerous change in their oesophagus, called Barrett’s oesophagus, were followed up for an average of 9 years resulting in over 20,000 life-years of follow up. After informed written consent, patients were randomly allocated to four different combinations; Low acid suppression alone, High acid suppression alone, low acid suppression with 300mg aspirin and high acid suppression with 300mg aspirin. We wanted to see if we could prevent progression to local cancer/cancer in-situ (high grade dysplasia), invasive cancer or prevent death by all causes both cancer and non-cancer.
Vicki Barber
BSc (Hons) ; FIoB; PhD Vicki Barber - OCTRU Operations Director and Interim Joint CTU Director
Maria Sanchez Santos
BSc, MSc Maria Sanchez Santos - NIHR Doctoral Research Fellow and DPhil candidate
David Beard
GDPhys, MCSP, MSc, MA, DPhil, FBOA (hon), FRCS (hon) David Beard - Professor of Musculoskeletal and Surgical Science
Adrian Kendal
MA (Oxon.) BMBCh, DPhil (Oxon.), FRCS (Ortho.) Adrian Kendal - Honorary Senior Clinical Lecturer
Hivine Zen-Aloush
Hivine Zen-Aloush - Grants Officer (Maternity Cover)
Chantelle Mbugua
Chantelle Mbugua - Research Administrative Assistant - Student Placement
Sue Davolls
Sue Davolls - Executive Assistant to Professor Jonathan Cook and Professor Anjan Thakurta