DPhil, MSc, BSc (Hons)
Jolet obtained her BSc (Hons) in Pharmaceutical Sciences from Utrecht University (the Netherlands), before moving to Oxford in 2015 for the MSc in Pharmacology. She then moved to the Botnar Research Centre in 2016 to read for a DPhil in Cellular and Molecular Medicine at NDORMS under the supervision of Prof. Andrew Carr, Assoc. Prof. Sarah Snelling, and Assoc. Prof. Stephanie Dakin. She worked on the project entitled “Inflammation in osteoarthritis – a focus on interleukin-17”, which she successfully defended in January 2020.
She currently works with Assoc. Prof. Sarah Snelling on tendon biology and osteoarthritis pathophysiology.
The Tendon Seed Network project is a CZI-funded project that aims to spatially define the transcriptome of healthy tendon, an extracellular matrix-rich tissue, across multiple anatomic and micro-anatomic sites. To enable this, the project will develop clinical, laboratory, bioinformatics, and mathematical modelling tools and platforms. Her work focusses on the development of laboratory protocols for the digestion of tendon for single nucleus RNA Sequencing.
Osteoarthritis is increasingly recognised as a whole joint disease, in which tissues such as synovium, ligaments, and the fat pad play an important role in disease. Our work focusses on defining and modifying synovial inflammation and fibrosis in osteoarthritis.
Nezhentsev A. et al, (2021), Translational sports medicine, 4, 409 - 418
Mimpen JY. et al, (2021), Front immunol, 12
Gacaferi H. et al, (2020), Translational sports medicine
INTERLEUKIN-17A, -F, AND -AF INDUCE EXPRESSION OF PRO-INFLAMMATORY GENES IN END-STAGE OSTEOARTHRITIS CHONDROCYTES AND SYNOVIAL FIBROBLASTS
Mimpen JY. et al, (2020), Osteoarthritis and cartilage, 28, S113 - S113
Mimpen JY. and Snelling SJB., (2019), Curr rheumatol rep, 21