National Rheumatoid Arthritis Society webinar
Senior Clinical Research Fellow, Director of Clinical Research
Chris Buckley obtained his first degree in Biochemistry from the University of Oxford (1985) with subsequent undergraduate training in Medicine at the Royal Free Hospital, London (1990).
His postgraduate medical training was in General Medicine and Rheumatology at the Hammersmith Hospital, London (Professors Mark Walport and Dorian Haskard), and John Radcliffe Hospital, Oxford. He obtained a DPhil (arising from a Wellcome Trust Clinical Training Fellowship) with Professor John Bell and Dr David Simmons at the Institute Molecular Medicine, Oxford.
In 1996, funded by a Wellcome Trust Clinician Scientist Fellowship, he joined the Department of Rheumatology in Birmingham. In 2001, he was awarded an MRC Senior Clinical Fellowship and in 2002 became Arthritis Research UK Professor of Rheumatology. In 2012, he was appointed Director of the Birmingham NIHR Clinical Research Facility. And in May 2017, he was appointed as Kennedy Professor of Translational Rheumatology.
In this joint academic post as Director of Clinical Research at the Kennedy Institute in Oxford and Director of NIHR Infrastructure for Birmingham Heath Partners he will lead the Arthritis Therapy Acceleration Programme (A-TAP) which aims to deliver “stratified pathology” in a range of immune mediated inflammatory diseases in order to choose the right disease indication for the right drug.
This approach complements stratified medicine where the aim is to choose the right drug for the right patient. As part of the Stromal Cell group at the Kennedy, his laboratory explores the role of fibroblasts in driving disease progression and tissue tropism in Rheumatoid Arthritis..
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a proinflammatory phenotype in Rheumatoid Arthritis
Wang Y. et al, (2021), Nature communications
The complement system drives local inflammatory tissue priming by metabolic reprogramming of articular fibroblasts
Friščić J. et al, (2021), Immunity
Fibroblasts as immune regulators in infection, inflammation and cancer
BUCKLEY C. et al, (2021), Nature reviews immunology
Metabolic Consequences for Mice Lacking Endosialin: LC-MS/MS-based Metabolic Phenotyping of Serum from C56Bl/6J Control and CD248 Knock-out Mice
Armitage EG. et al, (2021), Metabolomics
Location, location, location: understanding how the local tissue microenvironment drives inflammation in arthritis
BUCKLEY C. et al, (2020), Nature reviews rheumatology