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New research from a randomised clinical trial published today in The Lancet and funded by the National Institute for Health Research (NIHR) shows that partial knee replacements (PKR) are as good as total knee replacements (TKR), whilst being more cost effective.

Person holding their knee in pain. © Shutterstock
Maria Sanchez Santos

Maria Sanchez Santos

BSc, MSc Maria Sanchez Santos - NIHR Doctoral Research Fellow and DPhil candidate

Vandana Ayyar Gupta

Vandana Ayyar Gupta

PhD Vandana Ayyar Gupta - Honorary Clinical Study Coordinator

David Beard

David Beard

GDPhys, MCSP, MSc, MA, DPhil, FBOA (hon), FRCS (hon) David Beard - Professor of Musculoskeletal and Surgical Science

Vicki Barber

Vicki Barber

BSc (Hons) ; FIoB; PhD Vicki Barber - OCTRU Operations Director and Interim Joint CTU Director

Antonella Delmestri

Antonella Delmestri

PhD Antonella Delmestri - Lead Health Data Scientist

Cushla Cooper

Cushla Cooper

MSc, RN Cushla Cooper - Clinical Operational Lead

Adrian Kendal

Adrian Kendal

MA (Oxon.) BMBCh, DPhil (Oxon.), FRCS (Ortho.) Adrian Kendal - Honorary Senior Clinical Lecturer

Philippa Hulley

Philippa Hulley

BSc Med, BSc Med (Hons), PhD Philippa Hulley - Associate Professor

Cynthia Srikesavan

Cynthia Srikesavan

Cynthia Srikesavan - Senior Researcher in Physiotherapy

Srinivasa Rao Rao

Srinivasa Rao Rao

MBBS, MS (res), DPhil, AFHEA Srinivasa Rao Rao - Principal Investigator

Linyi Zhu

Linyi Zhu

Ph.D. Linyi Zhu - Senior Research Fellow

Beata Giglio

Beata Giglio

Beata Giglio - Programme Manager for Functional Genomics Cluster/EA/Project Manager

Gary Collins

Gary Collins

PhD Gary Collins - Professor of Medical Statistics and Director of CSM

Stephen Mellon

Stephen Mellon

BSc (Hons) and PhD Biomedical Engineering Stephen Mellon - Associate Professor Orthopaedic Biomechanics

Michael Dustin

Michael Dustin

Michael Dustin - Kennedy Trust Professor of Molecular Immunology

Stephanie Dakin

Stephanie Dakin

PhD BVetMed MRCVS PGCert TLHE FHEA Stephanie Dakin - Professor of Musculoskeletal Sciences

Joanna Black

Joanna Black

BSc, PhD Joanna Black - OCTRU Head of Regulatory Affairs and Quality Assurance (HoRAQ)

Philip Drennan

Philip Drennan

Philip Drennan - Senior Clinical Research Fellow in Clinical Therapeutics

Grace Drury

Grace Drury

MA Oxf, MA Grace Drury - Global Health Project Manager & Executive Assistant to Professor Chris Lavy

Jacqueline Harris

Jacqueline Harris

Jacqueline Harris - ORTEM Course Administrator

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Meet the NDORMS team

Read the paper

The clinical and cost effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised trial.

The Lancet 2019.

Full paper

In collaboration with

Health Services Research Unit | The University of Aberdeen

Funded by

National Institute for Health and Care Research logo

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