Cyrus Cooper
OBE, MA, DM, FRCP, FFPH, FMedSci
Professor of Musculoskeletal Science, University of Oxford
- Professor of Rheumatology and Director of the MRC Lifecourse Epidemiology Unit
- Vice-Dean of the Faculty of Medicine at the University of Southampton
Professor Cooper graduated from the University of Cambridge and St Bartholomew's Hospital, London in 1980, and completed his residency in 1985 at the Southampton University Hospitals.
In 1990, he won an MRC Travelling Fellowship to the Mayo Clinic, USA, where he continued his research in osteoporosis.
He returned to the UK in 1992 to take up a position as Senior Lecturer in Rheumatology and MRC Senior Clinical Scientist. He was promoted to the foundation Chair in Rheumatology at the University of Southampton in 1997 while continuing as an MRC Senior Clinical Scientist at the MRC Environmental Epidemiology Unit; in 2003 he was appointed Director of the MRC Epidemiology Resource Centre, University of Southampton.
In 2010, this was reconfigured as the MRC Lifecourse Epidemiology Unit; quinquennial funding has been extended from 2015 to 2020.
Professor Cooper leads an internationally competitive programme of research into the epidemiology of musculoskeletal disorders, most notably osteoporosis.
His key research contributions have been:
- discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood;
- demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood;
- characterisation of the definition and incidence rates of vertebral fractures;
- leadership of large pragmatic randomised controlled trials of calcium and vitamin D supplementation in the elderly as immediate preventative strategies against hip fracture.
Professor Cooper is Chairman of the Committee of Scientific Advisors, International Osteoporosis Foundation; Chair of the Arthritis Research UK Clinical Studies Initiative; Chair of the BHF Project Grants Committee; Vice-Dean at the Faculty of Medicine at the University of Southampton Medical School; an NIHR Senior Investigator; and Associate Editor of Osteoporosis International.
He has previously served as Chairman of the MRC Population Health Sciences Research Network; Chairman of the National Osteoporosis Society of Great Britain; past-President of the Bone Research Society of Great Britain; and has worked on numerous Department of Health, European Community and World Health Organisation committees and working groups.
He has published extensively (over 750 research papers) on osteoporosis and rheumatic disorders and pioneered clinical studies on the developmental origins of peak bone mass.
In 2015, he was awarded an OBE for services to medical research.
Key publications
Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy.
Journal article
Moon RJ. et al, (2016), J Clin Endocrinol Metab, 101, 5012 - 5020
Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.
Conference paper
Harvey NC. et al, (2014), J Bone Miner Res, 29, 600 - 607
Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women's Survey.
Journal article
Harvey NC. et al, (2014), J Clin Endocrinol Metab, 99, 330 - 337
Non-hip, non-spine fractures drive healthcare utilization following a fracture: the Global Longitudinal Study of Osteoporosis in Women (GLOW).
Journal article
Ioannidis G. et al, (2013), Osteoporos Int, 24, 59 - 67
Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study.
Journal article
Lalmohamed A. et al, (2012), BMJ, 345
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Journal article
Estrada K. et al, (2012), Nat Genet, 44, 491 - 501
Different indices of fetal growth predict bone size and volumetric density at 4 years of age.
Journal article
Harvey NC. et al, (2010), J Bone Miner Res, 25, 920 - 927
Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study.
Journal article
Inskip HM. et al, (2009), BMJ, 338
Parental determinants of neonatal body composition.
Journal article
Harvey NC. et al, (2007), J Clin Endocrinol Metab, 92, 523 - 526
Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.
Journal article
Javaid MK. et al, (2006), Lancet, 367, 36 - 43
Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial.
Journal article
Grant AM. et al, (2005), Lancet, 365, 1621 - 1628
Recent publications
Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study.
Journal article
Moon RJ. et al, (2023), J Clin Endocrinol Metab, 108, e726 - e733
Influences of the community and consumer nutrition environment on the food purchases and dietary behaviors of adolescents: A systematic review.
Journal article
Shaw S. et al, (2023), Obes Rev, 24
Evaluation and interpretation of latent class modelling strategies to characterise dietary trajectories across early life: a longitudinal study from the Southampton Women's Survey.
Journal article
Dalrymple KV. et al, (2023), Br J Nutr, 129, 1945 - 1954
Evaluation of two methods of bone age assessment in peripubertal children in Zimbabwe.
Journal article
Kowo-Nyakoko F. et al, (2023), Bone, 170
Fracture Risk in Men and Women With Vertebral Fractures Identified Opportunistically on Routine Computed Tomography Scans and Not Treated for Osteoporosis: An Observational Cohort Study.
Journal article
Skjødt MK. et al, (2023), JBMR Plus, 7