Jinsen Lu
MD.PhD
Postdoctoral Research Associate in Single Cell Assay Development
Anti-ageing therapy and bone cancer multiomics
Background and research
He is a qualified orthopaedic surgeon in china graduating from an 8 years bachelor-master integral surgical programme at AHMU in China. He complete my surgical resident training in 1st affiliated hospital of the university of science and technology in china with a focus on traumatic orthopaedics. He joined the group of musculoskeletal ageing and oncology led by prof. James Edwards and Claire Edwards in 2020 to study the extraskeletal effects of bisphosphonates. Then from 2024, he join the group of Udo Oppermann as a postdoctoral research associate to develop spatial single cell multiomics platform for research of multiple myeloma.
Current research focus on the following area:
1. Constructing multi-level (WGS/RNA/protein) platform with novel spatial single cell technique to study the pathology of multiple myeloma in various clinical settings.
2. Exploring the Anti-ageing potential and subcellular mechanism of novel bisphosphonates via systemic screening, multi-omics assessment, AI-based prediction and multi-level validation.
2. Development and evaluation of stem cell derived exosome loaded 3D bioprinting bone tissue engineering scaffold for diabetic bone lesion.
3. Exploring the novel mechanism of rare bone disease via single cell and spatial transcriptome sequencing.
4. Clinical trials and epidemiological analysis of orthopedic surgery.
Core competence
1. Experience of orthopedic surgery including ORIF of common limb fracture, TKA/THA and robot assisted pelvic CRIF and spine surgery.
2. Cell biology, molecular biology, microscopy and animal experiments.
3. RNAseq, scRNAseq, WGS, CETSA-MS, Proteomics/scProteomics, Xenium.
Collaboration
Welcome any collaboration from bone tissue engineering, WGBS, epigenetic ageing, advanced in vivo imaging, organoid culture and clinical trials.
Recent publications
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Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.
Preprint
Lu J. et al, (2025)
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Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway.
Journal article
Zhang T. et al, (2024), Int j oncol, 65
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Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.
Journal article
Lewis JW. et al, (2024), Cell rep med, 5
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Identification and Validation of the Prognostic Panel in Clear Cell Renal Cell Carcinoma Based on Resting Mast Cells for Prediction of Distant Metastasis and Immunotherapy Response.
Journal article
Su Y. et al, (2023), Cells, 12
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Association between socioeconomic status and survival in patients with hepatocellular carcinoma
Journal article
Zheng Y. et al, (2021), Cancer medicine, 10, 7347 - 7359
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Robot-assisted vs freehand cannulated screw placement in femoral neck fractures surgery
Journal article
Zheng Y. et al, (2021), Medicine, 100, e25926 - e25926
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TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice
Journal article
Zhang J. et al, (2019), Frontiers in physiology, 10
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Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence.
Journal article
Lu J. et al, (2019), Sci rep, 9