Jinsen Lu
MD.DPhil
Postdoctoral Research Associate in Single Cell and Spatial Multiomics Assay Development
Anti-Ageing Compounds and Spatial Multiomics in Bone Marrow Malignancies
Background and research
He is a qualified orthopaedic surgeon in china graduating from an 8 years bachelor-master integral surgical programme at AHMU in China. He complete my surgical resident training in 1st affiliated hospital of the university of science and technology in china with a focus on traumatic orthopaedics. He joined the group of musculoskeletal ageing and oncology led by prof. James Edwards and Claire Edwards in 2020 to study the extraskeletal effects of bisphosphonates. Then from 2024, he join the group of Udo Oppermann as a postdoctoral research associate to develop spatial single cell multiomics platform for research of multiple myeloma.
Current research focus on the following area:
1. Constructing multi-level (WGS/RNA/protein) platform with novel spatial single cell technique to study the pathology of multiple myeloma in various clinical settings.
2. Exploring the Anti-ageing potential and subcellular mechanism of novel bisphosphonates via systemic screening, multi-omics assessment, AI-based prediction and multi-level validation.
3.AI Spatial multiomics model of bone marrow malignancies.
4. Clinical trials and epidemiological analysis of bisphosphonates on multiple non-skeletal dieseases
Collaboration:
1.Real world data, clinical trial and large omics data based analysis for anti-ageing components and bisphosphoantes.
2.Advanced spatial multiomics platform and associated AI tools development for myeloma, bone and blood malignancies.
Recent publications
Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures.
Journal article
Lu J. et al, (2026), Signal Transduct Target Ther, 11
Bioactive 3D-bioprinted scaffolds with endothelial progenitor cells and Zn2+-enhanced SFMA/HisMA/nHAP for healing of infected bone defect
Journal article
Zhu Y. et al, (2026), MATERIALS TODAY ADVANCES, 29
Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.
Preprint
Lu J. et al, (2025)
Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.
Journal article
Lewis JW. et al, (2024), Cell Rep Med, 5
Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway.
Journal article
Zhang T. et al, (2024), Int J Oncol, 65
Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.
Journal article
Lewis JW. et al, (2024), Cell Rep Med, 5
Identification and Validation of the Prognostic Panel in Clear Cell Renal Cell Carcinoma Based on Resting Mast Cells for Prediction of Distant Metastasis and Immunotherapy Response.
Journal article
Su Y. et al, (2023), Cells, 12
Integrated Transcriptomic and Proteomic Profiling of Responses to Clinical and Novel Bisphosphonates Reveal Extraskeletal Effects and Protection Against Senescence
Conference paper
Lu J. et al, (2023), JOURNAL OF BONE AND MINERAL RESEARCH, 38, 426 - 426