Felix Clanchy
PhD, LLB
Senior Postdoctoral Researcher
- GMO Safety Committee
- LEAF
Contact information
- Undergraduate research on vaccine development for Vibrio anguillarum in rainbow trout, followed by honours research on glucose metabolism and obesity
- PhD at the University of Melbourne (CRC‑CID Scholar) studying macrophage-lineage cells in inflammatory disease
- Identification and characterisation of a monocyte population with increased proliferative and osteoclastic potential
- Postdoctoral training as a KIR Australasian Post‑Doctoral Fellow at Imperial College London’s Kennedy Institute of Rheumatology, moving later to the University of Oxford
- Research interests in innate immunology (TLRs/IRAK3/IDO1/CD74) and biomarker discovery
- Publications spanning monocyte biology, rheumatoid arthritis therapies, and early detection of disease relapse in cancer
Recent publications
Mechanistic impasses: tofacitinib treatment ameliorates GM-CSF-driven macrophage inflammation
Journal article
Clanchy FIL., (2026), Cellular & Molecular Immunology
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.
Journal article
Clanchy FIL. et al, (2026), Clin Rev Allergy Immunol, 69
Molecular immunology
Key publications
IRAK3 is upregulated in rheumatoid arthritis synovium and delays the onset of experimental arthritis.
Journal article
Borghese F. et al, (2025), Front Immunol, 16
Disease status in human and experimental arthritis, and response to TNF blockade, is associated with MHC class II invariant chain (CD74) isoform expression.
Journal article
Clanchy FIL. et al, (2022), J Autoimmun, 128
Ibudilast Inhibits Chemokine Expression in Rheumatoid Arthritis Synovial Fibroblasts and Exhibits Immunomodulatory Activity in Experimental Arthritis.
Journal article
Clanchy FIL. and Williams RO., (2019), Arthritis Rheumatol, 71, 703 - 711
CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease.
Journal article
Borghese F. and Clanchy FIL., (2011), Expert Opin Ther Targets, 15, 237 - 251
Monocytes
Key publications
High-Affinity Fc Receptor Expression Indicates Relative Immaturity in Human Monocytes.
Journal article
Clanchy FIL., (2016), J Interferon Cytokine Res, 36, 279 - 290
The development of macrophages from human CD34+ haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF.
Journal article
Clanchy FIL. and Hamilton JA., (2013), Cytokine, 61, 33 - 37
Proliferative monocyte frequency is associated with circulating monocyte prevalence.
Journal article
Clanchy FIL. and Hamilton JA., (2012), Leuk Res, 36, e175 - e177
HUVEC co-culture and haematopoietic growth factors modulate human proliferative monocyte activity.
Journal article
Clanchy FIL. and Hamilton JA., (2012), Cytokine, 59, 31 - 34
Detection and properties of the human proliferative monocyte subpopulation.
Journal article
Clanchy FIL. et al, (2006), J Leukoc Biol, 79, 757 - 766