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TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

Journal article

Fischer FA. et al, (2021), Proceedings of the national academy of sciences, 118, e2009309118 - e2009309118

Comparative analysis of the coordinated motion of Hsp70s from different organelles observed by single-molecule three-color FRET

Journal article

Voith von Voithenberg L. et al, (2021), Proceedings of the national academy of sciences, 118, e2025578118 - e2025578118

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling

Journal article

Chen KW. et al, (2021), Proceedings of the national academy of sciences, 118, e2101189118 - e2101189118

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Journal article

Santos JC. et al, (2020), Nature communications, 11

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Journal article

Demarco B. et al, (2020), Science advances, 6, eabc3465 - eabc3465

Cross talk between intracellular pathogens and cell death

Journal article

Demarco B. et al, (2020), Immunological reviews, 297, 174 - 193

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Journal article

Heilig R. et al, (2020), Life science alliance, 3, e202000735 - e202000735

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

Journal article

Chen KW. et al, (2020), European journal of immunology, 50, 170 - 177

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

Journal article

Chen KW. et al, (2020), The embo journal, 39

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

Journal article

Demarco B. et al, (2019), Molecular & cellular oncology, 6, 1610324 - 1610324

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly

Journal article

Chen KW. et al, (2019), The embo journal, 38

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Journal article

Rühl S. et al, (2018), Science, 362, 956 - 960