Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.
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TALAROZOLE, A RETINOIC ACID METABOLISM BLOCKING AGENT, SUPPRESSES MECHANOFLAMMATION AND ATTENUATES THE DEVELOPMENT OF POST-TRAUMATIC OA
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Murine joint destabilisation induces shear-responsive gene expression in the superficial cartilage which can be modified by a phospholipid-based lubricant
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Thicker cartilage and chondroprotection after joint destabilisation in CTGF null mice is due to compensation by Activin A
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The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis
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INTRA-ARTICULAR INJECTION OF PHOSPHOLIPID-BASED LUBRICANT REDUCES SHEAR-RESPONSIVE INFLAMMATORY GENES IN THE SUPERFICIAL LAYER OF CARTILAGE POST MURINE JOINT DESTABILISATION
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Molecular and skeletal characterization of mice with a fibrillin-1 mutation: insight into tissue bioavailability of TGF beta in Marfan syndrome
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THE MICROBIOME DOES NOT INFLUENCE CARTILAGE DEGRADATION FOLLOWING JOINT DESTABILISATION IN MICE WHEN PERFORMED UNDER STRINGENTLY CONTROLLED CONDITIONS
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TNF alpha-stimulated gene 6 (TSG-6) is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection
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Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage.
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Does pain at an earlier stage of chondropathy protect female mice from structural progression after surgically induced osteoarthritis?
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IS THE PARADOXICAL INCREASE OF CARTILAGE THICKNESS IN CTGF NULL MICE DUE TO COMPENSATION BY ACTIVIN A
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TNF ALPHA-STIMULATED GENE 6 (TSG6) IS CHONDROPROTECTIVE IN VIVO BUT OVEREXPRESSION CANNOT COMPENSATE FOR LOSS OF FGF2
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Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis.
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Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ.
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CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.
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