I obtained my PhD at the European Institute of Oncology in Milan.Here I unraveled mechanisms of regulation of gut vessels permeability in colorectal cancer fueled by the intratumoral bacteria.
In March 2020 I joined Prof. Fiona Powrie lab where I am currently investigating the role of a newly identified kinase, called Alpha Kinase 1 (Alpk1) during intestinal colitis. I will determine the physiological and pathophysiological relevance of this novel inflammatory checkpoint in mouse models and In human IBD.
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses.
Heuberger CE. et al, (2023), Mucosal immunol
A viral cocktail calms gut inflammation.
Bertocchi A. and Powrie F., (2022), Nature, 612, 220 - 221
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver
Bertocchi A. et al, (2021), Cancer cell, 39, 708 - 724.e11