Hideaki Nagase
Emeritus Professor
Recent publications
-
Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.
Yamamoto K. et al, (2017), Arthritis rheumatol, 69, 1246 - 1256
-
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.
Santamaria S. et al, (2017), Mabs, 9, 595 - 602
-
Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
Scilabra SD. et al, (2017), Matrix biol, 59, 69 - 79
-
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Yamamoto K. et al, (2016), Matrix biol, 56, 57 - 73
-
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
Doherty CM. et al, (2016), J biol chem, 291, 22160 - 22172