Jeremy Saklatvala

• Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.

  Lo Cascio L. et al, (2014), Genesis (New York, N.Y. : 2000), 52, 110 - 119

• Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo.

  Chong KW. et al, (2013), Arthritis and rheumatism, 65, 2346 - 2355

• INTERLEUKIN 1 INDUCES AGGRECAN DEGRADATION BY HUMAN ARTICULAR CHONDROCYTES THROUGH A TAK1/MKK4/JNK2 PATHWAY WITHOUT INVOLVEMENT OF NFKB

  Ismail HM. et al, (2013), OSTEOARTHRITIS AND CARTILAGE, 21, S127 - S127

• Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.

  Watt FE. et al, (2013), Arthritis and rheumatism, 65, 397 - 407

• Identifying synovial tissue-derived catabolic factors of cartilage aggrecan

  Rana F. et al, (2013), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 94, A38 - A38

• Heat shock protein B1-deficient mice display impaired wound healing.

  Crowe J. et al, (2013), PloS one, 8

• Generation of an inducible cartilage-specific deleter using human aggrecan enhancer/promoter that is trackable in vivo using luciferase

  Lo Cascio L. et al, (2012), GLYCOBIOLOGY, 22, 1576 - 1576

• Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

  Burleigh A. et al, (2012), Arthritis and rheumatism, 64, 2278 - 2288

• Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1.

  Joanny E. et al, (2012), British journal of pharmacology, 165, 1124 - 1136

• Pathogenic protease expression in murine OA is critically dependent upon mechanical joint loading

  Burleigh A. et al, (2012), ARTHRITIS RESEARCH & THERAPY, 14

• Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

  Buss H. et al, (2012), PloS one, 7

• The dependence of FGF2 on murine cartilage injury responses

  Chong KW. et al, (2011), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 92, A23 - A24

• Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent upon PKR phosphorylation.

  Lomas C. et al, (2011), European cells & materials, 22, 178 - 189

• PARTIAL JOINT IMMOBILISATION PROTECTS AGAINST OA AND REVEALS DISTINCT BIOMECHANICAL THRESHOLDS IN THE JOINT

  Burleigh A. et al, (2010), OSTEOARTHRITIS AND CARTILAGE, 18, S25 - S25

• MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.

  Marchese FP. et al, (2010), The Journal of biological chemistry, 285, 27590 - 27600

• The role of biomechanical factors in OA development

  Burleigh A. et al, (2010), European Cells and Materials, 20

• Structural and regulatory components of the pericellular matrix of young and mature articular cartilage

  McLean C. et al, (2010), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 91, A23 - A23

• MECHANICAL LOAD DRIVES INFLAMMATORY GENE EXPRESSION AND DISEASE IN MURINE OA

  Burleigh A. et al, (2010), RHEUMATOLOGY, 49, I32 - I32

• Connective tissue growth factor: matrix localisation, regulation and possible function in articular cartilage

  McLean C. et al, (2010), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 91, A24 - A24

• Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence.

  Tchen CR. et al, (2010), The Journal of biological chemistry, 285, 2642 - 2652

• The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese.

  Clark AR. et al, (2009), Arthritis and rheumatism, 60, 3513 - 3514

• Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

  Chia SL. et al, (2009), Arthritis and rheumatism, 60, 2019 - 2027

• The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.

  Tudor C. et al, (2009), FEBS letters, 583, 1933 - 1938

• Profound translational arrest during cyclical loading of porcine articular cartilage is followed by rebound increased protein synthesis in off loaded explants

  Vincent TL. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A134 - A134

• INTRACELLULAR SIGNALLING IN RESPONSE TO WOUNDING OF CONNECTIVE TISSUES

  Watt F. et al, (2009), RHEUMATOLOGY, 48, I9 - I9

• ADAMTS4 and ADAMTS5 are upregulated early in the DMM model of murine OA

  Burleigh A. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A108 - A108

• Activation of mitogen activated Protein Kinases (MAPKs) and gene induction upon explantation in articular cartilage from wild type and FGF-2(-/-) mice

  Chong K. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A108 - A109

• A novel JNK-regulated ribonucleoprotein complex that responds to cytokines and participates in inflammatory gene expression

  Rzeczkowski K. et al, (2009), NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 379, 39 - 39

• The possible interplay of mechanical and molecular factors in cartilage degeneration in osteoarthritis

  Saklatvala J., (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A48 - A49

• Regulation of secretion of connective tissue growth factor (CTGF) by heparin

  McLean C. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A59 - A60

• Past, Present and Future Insights into the Understanding and Treatment of Osteoarthritis: Molecular and Mechanical Approaches

  (2009), International Journal of Experimental Pathology, 90, A30 - A84

• Dexamethasone inhibits aggrecanolysis in human articular cartilage but promotes it in porcine tissue

  Sawaji Y. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A80 - A80

• Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage

  Didangelos A. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A59 - A59

• Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage

  Sawaji Y. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A78 - A78

• Activin A is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B

  Watt F. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A77 - A77

• A chondroprotective role for matrix-bound FGF2

  Chia S-L. et al, (2009), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90, A75 - A76

• Post-transcriptional gene regulation by MAP kinases via AU-rich elements.

  Clark A. et al, (2009), Frontiers in bioscience (Landmark edition), 14, 847 - 871

• Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.

  Sawaji Y. et al, (2008), Arthritis and rheumatism, 58, 3498 - 3509

• Is the response of cartilage to injury relevant to osteoarthritis?

  Vincent TL. and Saklatvala J., (2008), Arthritis and rheumatism, 58, 1207 - 1210

• Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B

  Watt F. et al, (2008), RHEUMATOLOGY, 47, II177 - II177

• Identification of cyclin-dependent kinase (CDK) 6 as a novel p65 NK-kappaB Ser536 kinase

  Buss H. et al, (2008), NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 377, 41 - 42

• Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.

  Alexander S. et al, (2007), Arthritis and rheumatism, 56, 3715 - 3725

• Cervical spine magnetic resonance imaging in primary care consulters with shoulder pain: a case control study.

  Paul A. et al, (2007), Annals of the rheumatic diseases, 66, 1363 - 1368

• Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components.

  Brikos C. et al, (2007), Molecular & cellular proteomics : MCP, 6, 1551 - 1559

• FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.

  Vincent TL. et al, (2007), Osteoarthritis and cartilage, 15, 752 - 763

• Accelerated disease in a surgical model of murine OA in mice lacking FGF-2

  Chia SL. et al, (2007), RHEUMATOLOGY, 46, I13 - I13

• Identification of target mRNAs regulated by both p38 MAPK and tristetraprolin in murine macrophages

  Tudor C. et al, (2007), IMMUNOLOGY, 120, 16 - 16

• Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.

  Alford KA. et al, (2007), The Journal of biological chemistry, 282, 6232 - 6241

• Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.

  Saklatvala J., (2007), Current drug targets, 8, 305 - 313

• Two-dimensional electrophoresis of proteins secreted from articular cartilage.

  Hermansson M. et al, (2007), Methods in molecular medicine, 136, 349 - 359

• Mapping lymphocyte plasma membrane proteins: a proteomic approach.

  Peirce MJ. et al, (2007), Methods in molecular medicine, 136, 361 - 367

• Dual specificity phosphatase-1 (DUSP-1) - A novel mediator of the anti-inflammatory effects of glucocorticoids?

  Abraham SM. et al, (2006), ARTHRITIS AND RHEUMATISM, 54, S513 - S513

• Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.

  Catterall JB. et al, (2006), Rheumatology (Oxford, England), 45, 1101 - 1109

• Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

  Abraham SM. et al, (2006), The Journal of experimental medicine, 203, 1883 - 1889

• Basic fibroblast growth factor: An extracellular mechanotransducer in articular cartilage?

  Vincent T. and Saklatvala J., (2006), Biochemical Society Transactions, 34, 456 - 457

• Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?

  Vincent T. and Saklatvala J., (2006), Biochemical Society transactions, 34, 456 - 457

• Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes

  Watt FE. et al, (2006), RHEUMATOLOGY, 45, I82 - I82

• Pericellular matrix of articular cartilage. A novel mechanotransduction mechanism in articular chondrocytes?

  Vincent TL. et al, (2006), RHEUMATOLOGY, 45, I23 - I23

• Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

  Brook M. et al, (2006), Molecular and cellular biology, 26, 2408 - 2418

• Proteomic analysis of T cell-contact dependent activation of macrophages; Identification of an antigen independent immune synapse.

  Cope AP. et al, (2005), ARTHRITIS AND RHEUMATISM, 52, S493 - S494

• Detection of novel tyrosine-phosphorylated proteins in macrophages by proteomic analysis

  Wait R. et al, (2005), MOLECULAR & CELLULAR PROTEOMICS, 4, S283 - S283

• Two-stage affinity purification for inducibly phosphorylated membrane proteins.

  Peirce MJ. et al, (2005), Proteomics, 5, 2417 - 2421

• The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR (vol 21, pg 721, 2001)

  Dean JLE. et al, (2005), MOLECULAR AND CELLULAR BIOLOGY, 25, 3400 - 3400

• Erratum: The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR (Molecular and Cellular Biology (2001) 21:3 (721-730))

  Dean JLE. et al, (2005), Molecular and Cellular Biology, 25

• Proteomic characterisation of cell contact-dependent macrophage activation

  Peirce MJ. et al, (2005), ARTHRITIS RESEARCH & THERAPY, 7, S29 - S29

• The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

  Dean JL. et al, (2004), Cellular signalling, 16, 1113 - 1121

• Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

  Hermansson M. et al, (2004), The Journal of biological chemistry, 279, 43514 - 43521

• The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.

  Saklatvala J., (2004), Current opinion in pharmacology, 4, 372 - 377

• Induction of interleukin-1 in articular cartilage by explantation and cutting.

  Gruber J. et al, (2004), Arthritis and rheumatism, 50, 2539 - 2546

• The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself.

  Tchen CR. et al, (2004), The Journal of biological chemistry, 279, 32393 - 32400

• Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1).

  Sully G. et al, (2004), The Biochemical journal, 377, 629 - 639

• Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.

  Vincent TL. et al, (2004), Arthritis and rheumatism, 50, 526 - 533

• Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18-20 April 2004.

  Saklatvala J. and Nagase H., (2004), Arthritis research & therapy, 6, 203 - 207

• Expression profiling of lymphocyte plasma membrane proteins.

  Peirce MJ. et al, (2004), Molecular & cellular proteomics : MCP, 3, 56 - 65

• Biochemical Society Symposium: Preface

  Saklatvala J. et al, (2003), Biochemical Society Symposium

• p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation.

  Dean JL. et al, (2003), The Journal of biological chemistry, 278, 39470 - 39476

• Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

  Clark AR. et al, (2003), FEBS letters, 546, 37 - 44

• STRUCTURAL CERVICAL SPINE ABNORMALITIES AND SHOULDER REGION PAIN: IS THERE AN ASSOCIATION?

  Paul A. et al, (2003), RHEUMATOLOGY, 42, 36 - 36

• Control of the expression of inflammatory response genes.

  Saklatvala J. et al, (2003), Biochemical Society symposium, 95 - 106

• A tribute to Alan J. Barrett.

  Saklatvala J. et al, (2003), Biochemical Society symposium, ix - x

• Transcriptional and post-transcriptional control of gene expression in inflammation.

  Kracht M. and Saklatvala J., (2002), Cytokine, 20, 91 - 106

• Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.

  Lasa M. et al, (2002), Molecular and cellular biology, 22, 7802 - 7811

• Identification of a novel AU-rich-element-binding protein which is related to AUF1

  Dean JLE. et al, (2002), Biochemical Journal, 366, 709 - 719

• Identification of a novel AU-rich-element-binding protein which is related to AUF1.

  Dean JL. et al, (2002), The Biochemical journal, 366, 709 - 719

• Basic FGF mediates an immediate response of articular cartilage to mechanical injury.

  Vincent T. et al, (2002), Proceedings of the National Academy of Sciences of the United States of America, 99, 8259 - 8264

• BASIC FIBROBLAST GROWTH FACTOR (bFGF) MEDIATES THE IMMEDIATE INJURY RESPONSE IN ARTICULAR CARTILAGE

  Vincent TL. et al, (2002), RHEUMATOLOGY, 41, 21 - 22

• Glucocorticoids: do we know how they work?

  Saklatvala J., (2002), Arthritis research, 4, 146 - 150

• Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.

  Mahtani KR. et al, (2001), Molecular and Cellular Biology, 21, 6461 - 6469

• Basic fibroblast growth factor (FGF) mediator of the immediate injury response in articular cartilage

  Vincent TI. et al, (2001), ARTHRITIS AND RHEUMATISM, 44, S64 - S64

• The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

  Dean JL. et al, (2001), Molecular and cellular biology, 21, 721 - 730

• Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38.

  Lasa M. et al, (2001), Molecular and cellular biology, 21, 771 - 780

• Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: Activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7

  Finch A. et al, (2001), Biochemical Journal, 353, 275 - 281

• Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7.

  Finch A. et al, (2001), The Biochemical journal, 353, 275 - 281

• Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade.

  Brook M. et al, (2000), FEBS letters, 483, 57 - 61

• Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.

  Lasa M. et al, (2000), Molecular and cellular biology, 20, 4265 - 4274

Recent Publications

• Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.

  Lo Cascio L. et al, (2014), Genesis (New York, N.Y. : 2000), 52, 110 - 119

• Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo.

  Chong KW. et al, (2013), Arthritis and rheumatism, 65, 2346 - 2355

• INTERLEUKIN 1 INDUCES AGGRECAN DEGRADATION BY HUMAN ARTICULAR CHONDROCYTES THROUGH A TAK1/MKK4/JNK2 PATHWAY WITHOUT INVOLVEMENT OF NFKB

  Ismail HM. et al, (2013), OSTEOARTHRITIS AND CARTILAGE, 21, S127 - S127

• Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.

  Watt FE. et al, (2013), Arthritis and rheumatism, 65, 397 - 407

• Identifying synovial tissue-derived catabolic factors of cartilage aggrecan

  Rana F. et al, (2013), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 94, A38 - A38