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Contact information


kristina.clark@ndorms.ox.ac.uk

Kristina Clark

Academic Clinical Lecturer in Rheumatology

Fibrosis across tissues in systemic sclerosis and across diseases

I am currently an Academic Clinical Lecturer in Rheumatology at the Kennedy Institute of Rheumatology, and an honorary Rheumatology consultant at the Royal Free Hospital and Oxford University Hospitals. I have a primary research interest into fibrosis in Systemic sclerosis. I was awarded an MRC Clinical Training Fellowship in 2019, and carried out my PhD at UCL, within the Centre for Rheumatology and Connective Tissue Diseases, and at the Kennedy Institute of Rheumatology. This project focused primarily on identifying fibroblast subsets in the skin of patients with systemic sclerosis, and how these differ based on stage and autoantibody subsets. I now aim to focus on fibrosis within the gastrointestinal system, a complication affecting over 90% of patients with systemic sclerosis

Key publications

Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin.

Journal article

Clark KE. et al, (2025), JCI Insight, 10

Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups.

Journal article

Clark KEN. et al, (2023), Ann Rheum Dis, 82, 1568 - 1579

Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study.

Journal article

Clark KEN. et al, (2022), Lancet Rheumatol, 4, e507 - e516

Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis.

Journal article

Clark KEN. et al, (2021), Ann Rheum Dis, 80, 1584 - 1593

Unravelling extracellular matrix biomarkers in systemic sclerosis.

Journal article

Clark KEN. and Denton CP., (2021), Lancet Rheumatol, 3, e162 - e163

Recent publications

Vaping and vascular health-emerging risks for Raynaud's, chilblains & Buerger's disease.

Journal article

Amin M. et al, (2026), Rheumatology (Oxford)

OA10 Using single-cell technology to understand the cellular landscape of colonic disease in systemic sclerosis

Conference paper

Clark KEN. et al, (2026), Rheumatology, 65

Old Techniques Still Have Relevance in Personalized Predictive Medicine.

Journal article

Clark KEN. and Denton CP., (2026), Arthritis Rheumatol, 78, 285 - 286

A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial.

Journal article

Rodolfi S. et al, (2025), Arthritis Res Ther, 28

Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin.

Journal article

Clark KE. et al, (2025), JCI Insight, 10

More publications