Sir Marc Feldmann FRS

• Macrophage heterogeneity in the context of rheumatoid arthritis.

  Udalova IA. et al, (2016), Nature reviews. Rheumatology, 12, 472 - 485

• Anti-TNF Therapy.

  Udalova I. et al, (2016), Microbiology spectrum, 4

• Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

  Cole JE. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 13033 - 13038

• Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

  Cribbs A. et al, (2015), Therapeutic advances in musculoskeletal disease, 7, 206 - 219

• Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.

  Espirito Santo AI. et al, (2015), Biochemical and biophysical research communications, 464, 1145 - 1150

• Perspectives From Masters in Rheumatology and Autoimmunity: Can We Get Closer to a Cure for Rheumatoid Arthritis?

  Feldmann M. and Maini RN., (2015), Arthritis & rheumatology (Hoboken, N.J.), 67, 2283 - 2291

• IRF5 controls both acute and chronic inflammation.

  Weiss M. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 11001 - 11006

• IRF5 controls both acute and chronic inflammation

  Weiss M. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 11001 - 11006

• Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.

  Chan JK. et al, (2015), EMBO molecular medicine, 7, 547 - 561

• Preclinical target validation using patient-derived cells.

  Edwards AM. et al, (2015), Nature reviews. Drug discovery, 14, 149 - 150

• Anti-TNF therapy: past, present and future.

  Monaco C. et al, (2015), International immunology, 27, 55 - 62

• Discovery and Development of Anti-TNF Therapy: Pillar of a Therapeutic Revolution. Pillar of a Therapeutic Revolution.

  Feldmann M., (2014), Molecular Biology of B Cells: Second Edition, 541 - 547

• Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitis

  Wythe SE. et al, (2014), IMMUNOLOGY, 143, 162 - 162

• Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

  McCann FE. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 2728 - 2738

• Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  Nielsen N. et al, (2014), Immunology, 142, 581 - 593

• Reply: To PMID 23784528.

  Schmidt EM. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 1962 - 1963

• TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

  Ruspi G. et al, (2014), Cellular signalling, 26, 683 - 690

• OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

  Gwyer Findlay E. et al, (2014), Proceedings of the National Academy of Sciences of the United States of America, 111, 2289 - 2294

• A conversation with Marc Feldmann. Interviewed by Ushma S. Neill.

  Feldmann M., (2014), The Journal of clinical investigation, 124, 1 - 2

• Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

  Terrando N. et al, (2014), Molecular medicine (Cambridge, Mass.), 20, 667 - 675

• Design and optimisation of bioactive cyclic peptides: generation of a down-regulator of TNF secretion.

  New R. et al, (2014), Molecules (Basel, Switzerland), 19, 21529 - 21540

• Anti-tnf therapy: 20 years from our first therapeutic adventure

  Nanchahal J. et al, (2014), Cytokine Frontiers: Regulation of Immune Responses in Health and Disease, 215 - 244

• Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

  Schmidt EM. et al, (2013), Arthritis and rheumatism, 65, 2262 - 2273

• Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

  Verjee LS. et al, (2013), Proceedings of the National Academy of Sciences of the United States of America, 110, E928 - E937

• RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.

  Gasparini C. et al, (2013), Cytokine, 61, 736 - 740

• TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes.

  Brenner C. et al, (2012), Scandinavian journal of immunology, 76, 359 - 370

• Alarmins: awaiting a clinical response.

  Chan JK. et al, (2012), The Journal of clinical investigation, 122, 2711 - 2719

• Effective targeting of the tumor microenvironment for cancer therapy.

  Jiang P. et al, (2012), Anticancer research, 32, 1203 - 1212

• NF-κB as a target for modulating inflammatory responses.

  Gasparini C. and Feldmann M., (2012), Current pharmaceutical design, 18, 5735 - 5745

• Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis.

  Raatz Y. et al, (2012), Arthritis research & therapy, 14

• Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA.

  Larsen H. et al, (2012), Arthritis research & therapy, 14

• The TNF/TNF-R family: A gold mine for clinical therapeutic targets?

  Feldmann M., (2011), Advances in Experimental Medicine and Biology, 691, ix - x

• Resolving postoperative neuroinflammation and cognitive decline.

  Terrando N. et al, (2011), Annals of neurology, 70, 986 - 995

• Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

  Beavis PA. et al, (2011), Proceedings of the National Academy of Sciences of the United States of America, 108, 16717 - 16722

• Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.

  Andersson AK. et al, (2011), Arthritis and rheumatism, 63, 2617 - 2629

• IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

  McNamee KE. et al, (2011), Pain, 152, 1838 - 1845

• IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

  Krausgruber T. et al, (2011), Nature immunology, 12, 231 - 238

• Unexpected protective role for Toll-like receptor 3 in the arterial wall.

  Cole JE. et al, (2011), Proceedings of the National Academy of Sciences of the United States of America, 108, 2372 - 2377

• TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.

  Glass GE. et al, (2011), Proceedings of the National Academy of Sciences of the United States of America, 108, 1585 - 1590

• Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade.

  Gompels LL. et al, (2011), Arthritis research & therapy, 13

• Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.

  Turner JJ. et al, (2010), Clinical and experimental immunology, 162, 487 - 493

• Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

  Terrando N. et al, (2010), Proceedings of the National Academy of Sciences of the United States of America, 107, 20518 - 20522

• Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis.

  Malik NM. et al, (2010), Rheumatology (Oxford, England), 49, 1828 - 1839

• Role of interleukin-1beta in postoperative cognitive dysfunction.

  Cibelli M. et al, (2010), Annals of neurology, 68, 360 - 368

• Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

  Page TH. et al, (2010), Journal of immunology (Baltimore, Md. : 1950), 185, 3694 - 3701

• IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.

  Smallie T. et al, (2010), The Journal of experimental medicine, 207, 2081 - 2088

• The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.

  Weng L. et al, (2010), Annals of the rheumatic diseases, 69, 1519 - 1526

• SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

  Drexler SK. et al, (2010), Arthritis and rheumatism, 62, 2249 - 2261

• Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

  Feldmann M. and Maini RN., (2010), Journal of immunology (Baltimore, Md. : 1950), 185, 791 - 794

• Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

  Drexler SK. et al, (2010), Scandinavian journal of immunology, 71, 393 - 402

• Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.

  McNamee KE. et al, (2010), Pain, 149, 386 - 392

• Directed issue: novel concepts in inflammation.

  Gilroy DW. et al, (2010), The international journal of biochemistry & cell biology, 42, 480 - 481

• Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis.

  Dobson R. et al, (2010), Journal of neuroimmunology, 220, 99 - 103

• What have we learnt from targeted anti-TNF therapy?

  Feldmann M. et al, (2010), Annals of the rheumatic diseases, 69 Suppl 1, i97 - i99

• The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.

  Terrando N. et al, (2010), Critical care (London, England), 14

• Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.

  Wegner N. et al, (2010), Immunological reviews, 233, 34 - 54

• Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

  McCann FE. et al, (2010), Arthritis research & therapy, 12

• Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.

  Monaco C. et al, (2009), Circulation, 120, 2462 - 2469

• Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

  Hillyer P. et al, (2009), Rheumatology (Oxford, England), 48, 1581 - 1589

• TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

  Kuai J. et al, (2009), Rheumatology (Oxford, England), 48, 1352 - 1358

• Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.

  Taylor PC. and Feldmann M., (2009), Nature reviews. Rheumatology, 5, 578 - 582

• A view from a European medical academic who spends time in the US.

  Feldmann M., (2009), The Journal of clinical investigation, 119, 2861 - 2862

• RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

  Gasparini C. et al, (2009), European journal of immunology, 39, 2215 - 2223

• Translating molecular insights in autoimmunity into effective therapy.

  Feldmann M., (2009), Annual review of immunology, 27, 1 - 27

• Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

  Sumariwalla PF. et al, (2009), Rheumatology (Oxford, England), 48, 32 - 38

• In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.

  Brennan F. and Feldmann M., (2009), Arthritis research & therapy, 11

• Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

  Sacre SM. et al, (2008), Journal of immunology (Baltimore, Md. : 1950), 181, 8002 - 8009

• Many cytokines are very useful therapeutic targets in disease.

  Feldmann M., (2008), The Journal of clinical investigation, 118, 3533 - 3536

• Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

  Inglis JJ. et al, (2008), Arthritis and rheumatism, 58, 3110 - 3119

• Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

  Raichel L. et al, (2008), European journal of immunology, 38, 2905 - 2915

• Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.

  Sumariwalla PF. et al, (2008), Arthritis and rheumatism, 58, 3071 - 3080

• Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.

  Andersson AK. et al, (2008), Scandinavian journal of immunology, 68, 103 - 111

• Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.

  Feldmann M. and Maini SR., (2008), Immunological reviews, 223, 7 - 19

• Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

  Williams LM. et al, (2008), Molecular immunology, 45, 2446 - 2454

• CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.

  Simelyte E. et al, (2008), Arthritis and rheumatism, 58, 1038 - 1043

• Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.

  Brennan FM. et al, (2008), Arthritis research & therapy, 10

• Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

  Jin P. et al, (2008), Arthritis research & therapy, 10

• Targeting intracellular signaling: a novel approach to vaccination.

  Wales J. et al, (2007), Expert review of vaccines, 6, 971 - 980

• Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

  Wales J. et al, (2007), Biochemical Society transactions, 35, 1501 - 1503

• Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.

  Inglis JJ. et al, (2007), Arthritis and rheumatism, 56, 4015 - 4023

• Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

  Lundberg AM. et al, (2007), Blood, 110, 3245 - 3252

• Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

  Sacre SM. et al, (2007), Annals of the rheumatic diseases, 66 Suppl 3, iii81 - iii86

• The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.

  Inglis JJ. et al, (2007), Rheumatology (Oxford, England), 46, 1428 - 1432

• Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.

  Williams RO. et al, (2007), Current opinion in pharmacology, 7, 412 - 417

• Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.

  Sheryanna A. et al, (2007), Journal of the American Society of Nephrology : JASN, 18, 1167 - 1179

• Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

  Bondeson J. et al, (2007), The Journal of rheumatology, 34, 523 - 533

• A new JCI conflict-of-interest policy.

  Neill US. et al, (2007), The Journal of clinical investigation, 117, 506 - 508

• The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.

  Sacre SM. et al, (2007), The American journal of pathology, 170, 518 - 525

• Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.

  Sacre SM. et al, (2007), Journal of immunology (Baltimore, Md. : 1950), 178, 2148 - 2154

• The pitfalls in the development of biologic therapy.

  Maini RN. and Feldmann M., (2007), Nature clinical practice. Rheumatology, 3

• Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.

  Edwards CJ. et al, (2007), Molecular medicine (Cambridge, Mass.), 13, 40 - 58

• Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.

  Tyndall A. et al, (2007), Arthritis research & therapy, 9

• Crystal-ball gazing--the future of immunological research viewed from the cutting edge.

  Brent L. et al, (2007), Clinical and experimental immunology, 147, 1 - 10

• Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.

  Inglis JJ. et al, (2007), Arthritis research & therapy, 9

• Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

  Amos N. et al, (2006), Rheumatology (Oxford, England), 45, 1201 - 1209

• Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.

  Andreakos E. et al, (2006), Proceedings of the National Academy of Sciences of the United States of America, 103, 14459 - 14464

• Cytokines as therapeutics and targets of therapeutics

  Vilček J. and Feldmann M., (2006), Rheumatologia, 20, 65 - 74

• Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.

  Feldmann M. and Pusey CD., (2006), Journal of the American Society of Nephrology : JASN, 17, 1243 - 1252

• Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.

  Grosjean J. et al, (2006), Biochemical and biophysical research communications, 340, 984 - 994

• The importance of T cell interactions with macrophages in rheumatoid cytokine production.

  Brennan FM. et al, (2006), Current topics in microbiology and immunology, 305, 177 - 194

• Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

  Waterston AM. et al, (2005), Cancer immunology, immunotherapy : CII, 54, 848 - 857

• Molecular therapeutic targets in rheumatoid arthritis.

  Sacre SM. et al, (2005), Expert reviews in molecular medicine, 7, 1 - 20

• Design of effective immunotherapy for human autoimmunity.

  Feldmann M. and Steinman L., (2005), Nature, 435, 612 - 619

• The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.

  Andreakos E. et al, (2005), Frontiers in bioscience : a journal and virtual library, 10, 2478 - 2488

• Cannabinoids in Models of Chronic Inflammatory Conditions

  Mechoulam R. et al, (2005), Phytochemistry Reviews, 4, 11 - 18

• Anti-TNF therapy: where have we got to in 2005?

  Feldmann M. et al, (2005), Journal of autoimmunity, 25 Suppl, 26 - 28

• Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.

  Taylor PC. et al, (2004), Current opinion in biotechnology, 15, 557 - 563

• Rheumatoid arthritis: pathogenic mechanisms and therapeutic targets

  Taylor PC. and Feldmann M., (2004), Drug Discovery Today: Disease Mechanisms, 1, 289 - 295

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

  Burstein S. and Zurier RB., (2004), Arthritis and rheumatism, 50, 4078 - 4079

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al - Reply

  Sumariwalla PF. et al, (2004), ARTHRITIS AND RHEUMATISM, 50, 4079 - 4080

• Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?

  Andreakos E. et al, (2004), Immunological reviews, 202, 250 - 265

• Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.

  Cope AP. and Feldmann M., (2004), Current opinion in immunology, 16, 780 - 786

• A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.

  Campbell J. et al, (2004), Journal of immunology (Baltimore, Md. : 1950), 173, 6928 - 6937

• Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages.

  Pertyńska-Marczewska M. et al, (2004), Cytokine, 28, 35 - 47

• New approaches to therapeutic immunomodulation for immune-mediated inflammatory disorders.

  Taylor PC. and Feldmann M., (2004), Current opinion in pharmacology, 4, 368 - 371

• Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.

  Monaco C. et al, (2004), Proceedings of the National Academy of Sciences of the United States of America, 101, 5634 - 5639

• P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.

  Sumariwalla PF. et al, (2004), Clinical and experimental immunology, 136, 67 - 75

• Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.

  Zhang Y. et al, (2004), The Journal of pharmacology and experimental therapeutics, 309, 348 - 355

• Historical review: Cytokines as therapeutics and targets of therapeutics.

  Vilcek J. and Feldmann M., (2004), Trends in pharmacological sciences, 25, 201 - 209

• TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.

  Waterston AM. et al, (2004), British Journal of Cancer, 90, 1279 - 1284

• T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.

  Monaco C. et al, (2004), Current drug targets. Inflammation and allergy, 3, 35 - 42

• Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

  Andreakos E. et al, (2004), Blood, 103, 2229 - 2237

• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

  Sumariwalla PF. et al, (2004), Arthritis and rheumatism, 50, 985 - 998

• The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.

  Feldmann M. et al, (2004), Best practice & research. Clinical rheumatology, 18, 59 - 80

• Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

  Sacre SM. et al, (2004), Journal of endotoxin research, 10, 445 - 452

• Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

  Feldmann M. et al, (2004), Novartis Foundation symposium, 256, 53 - 269

• Advanced glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells

  Pertńaska-Marczewska M. et al, (2003), Diabetologia Polska, 10, 375 - 380

• Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.

  Foxwell B. et al, (2003), Annals of the rheumatic diseases, 62 Suppl 2, ii90 - ii93

• Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis.

  Afuwape AO. et al, (2003), Gene therapy, 10, 1950 - 1960

• TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

  Feldmann M. and Maini RN., (2003), Nature Medicine, 9, 1245 - 1250

• Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.

  Feldmann M. and Maini RN., (2003), Nature medicine, 9, 1245 - 1250

• Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.

  Yoshimura S. et al, (2003), Scandinavian journal of immunology, 58, 165 - 172

• Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.

  Scheinin T. et al, (2003), Clinical and experimental immunology, 133, 38 - 43

• Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.

  Andreakos E. et al, (2003), Arthritis and rheumatism, 48, 1901 - 1912

• Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response.

  Mauri C. et al, (2003), Arthritis and rheumatism, 48, 839 - 845

• Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.

  Calder VL. et al, (2003), Scandinavian journal of immunology, 57, 261 - 270

• VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.

  Kiriakidis S. et al, (2003), Journal of cell science, 116, 665 - 674

• Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.

  Andreakos E. et al, (2003), Blood, 101, 983 - 991

• The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.

  Sumariwalla PF. et al, (2003), Arthritis research & therapy, 5, R32 - R39

• Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.

  Foey AD. et al, (2003), Arthritis research & therapy, 5, R317 - R328

• Monoclonal antibodies in immune and inflammatory diseases.

  Andreakos E. et al, (2002), Current opinion in biotechnology, 13, 615 - 620

• Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

  Feldmann M. et al, (2002), Annals of the rheumatic diseases, 61 Suppl 2, ii13 - ii18

• Cytokines and anti-cytokine biologicals in autoimmunity: present and future.

  Andreakos ET. et al, (2002), Cytokine & growth factor reviews, 13, 299 - 313

• TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.

  Ciesielski CJ. et al, (2002), European journal of immunology, 32, 2037 - 2045

• Development of anti-TNF therapy for rheumatoid arthritis.

  Feldmann M., (2002), Nature reviews. Immunology, 2, 364 - 371

• T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.

  Monaco C. et al, (2002), Journal of leukocyte biology, 71, 659 - 668

• How does infliximab work in rheumatoid arthritis?

  Maini RN. and Feldmann M., (2002), Arthritis research, 4 Suppl 2, S22 - S28

• High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.

  Horwood NJ. et al, (2002), Arthritis research, 4 Suppl 3, S215 - S225

• Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.

  Brennan FM. et al, (2002), Arthritis and rheumatism, 46, 31 - 41

• Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.

  Feldmann M. and Maini RN., (2002), Joint, bone, spine : revue du rhumatisme, 69, 12 - 18

• Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.

  Foey A. et al, (2002), Arthritis research, 4, 64 - 70

• NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts

  Smith C. et al, (2001), Journal of Immunology, 167, 5895 - 5903

• NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.

  Smith C. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 167, 5895 - 5903

• High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.

  Foxwell BM. et al, (2001), Annals of the rheumatic diseases, 60 Suppl 3, iii13 - iii17

• CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.

  Foey AD. et al, (2001), Cytokine, 16, 131 - 142

• Immunotherapy - Editorial overview

  Feldmann M., (2001), CURRENT OPINION IN IMMUNOLOGY, 13, 595 - 596

• Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.

  Ballara S. et al, (2001), Arthritis and rheumatism, 44, 2055 - 2064

• Pathogenesis of arthritis: recent research progress.

  Feldmann M., (2001), Nature immunology, 2, 771 - 773

• Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.

  Conron M. et al, (2001), American journal of respiratory cell and molecular biology, 25, 141 - 149

• Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.

  Yoshimura S. et al, (2001), European journal of immunology, 31, 1883 - 1893

• Gene therapy for rheumatoid arthritis?

  Feldmann M., (2001), The Journal of clinical investigation, 107

• Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.

  Quattrocchi E. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 5970 - 5978

• Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.

  Yoshimura S. et al, (2001), International immunology, 13, 675 - 683

• Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.

  Malfait AM. et al, (2001), Arthritis and rheumatism, 44, 1215 - 1224

• Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.

  Feldmann M. et al, (2001), Transplantation proceedings, 33, 2085 - 2086

• The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy.

  Yamamoto AM. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 4973 - 4980

• [Cellular mechanisms of regulation of the inflammatory response in atherosclerosis: the role of cell contact-mediated signaling]

  Monaco C. et al, (2001), Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2, 339 - 343

• Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system.

  Croxford JL. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 4124 - 4130

• Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.

  Gabay C. et al, (2001), Arthritis and rheumatism, 44, 451 - 462

• The role of TNF alpha and IL-1 in rheumatoid arthritis.

  Feldmann M. et al, (2001), Current directions in autoimmunity, 3, 188 - 199

• Cytokine blockade in rheumatoid arthritis.

  Feldmann M. et al, (2001), Advances in experimental medicine and biology, 490, 119 - 127

• Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

  Feldmann M. and Maini RN., (2001), Annual review of immunology, 19, 163 - 196

• [Recombinant adenovirus-mediated gene transfer suppresses experimental arthritis]

  Quattrocchi E. and Feldmann M., (2001), Reumatismo, 53, 46 - 54

• Insights into the pathogenesis of rheumatoid arthritis from application of anti-TNF therapy.

  Maini RN. et al, (2000), Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 23, 487 - 489

• Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.

  Williams RO. et al, (2000), Journal of immunology (Baltimore, Md. : 1950), 165, 7240 - 7245

• Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis (May 2000).

  Furst DE. et al, (2000), Annals of the rheumatic diseases, 59 Suppl 1, i1 - i2

• Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

  Lipsky PE. et al, (2000), The New England journal of medicine, 343, 1594 - 1602

• Future prospects for anti-cytokine treatment.

  Feldmann M. et al, (2000), Annals of the rheumatic diseases, 59 Suppl 1, i119 - i122

• Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.

  Williams RO. et al, (2000), Annals of the rheumatic diseases, 59 Suppl 1, i75 - i80

• Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials.

  Charles PJ. et al, (2000), Arthritis and rheumatism, 43, 2383 - 2390

• Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.

  Foxwell BM. et al, (2000), Annals of the rheumatic diseases, 59 Suppl 1, i54 - i59

• Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.

  Foey AD. et al, (2000), Cytokine, 12, 1496 - 1505

• Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.

  Bondeson J. et al, (2000), The Journal of rheumatology, 27, 2078 - 2089

• Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis.

  Miotla J. et al, (2000), Laboratory investigation; a journal of technical methods and pathology, 80, 1195 - 1205

• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

  Malfait AM. et al, (2000), Proceedings of the National Academy of Sciences of the United States of America, 97, 9561 - 9566

• Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis.

  Quattrocchi E. et al, (2000), Arthritis and rheumatism, 43, 1688 - 1697

• Gene therapy for chronic relapsing experimental allergic encephalomyelitis using cells expressing a novel soluble p75 dimeric TNF receptor.

  Croxford JL. et al, (2000), Journal of immunology (Baltimore, Md. : 1950), 164, 2776 - 2781

• A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.

  Marinova-Mutafchieva L. et al, (2000), Arthritis and rheumatism, 43, 638 - 644

• TNF as a therapeutic target

  Bondeson J. et al, (2000), IMMUNOLOGIST, 8, 136 - 140

• Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.

  Taylor PC. et al, (2000), Arthritis and rheumatism, 43, 38 - 47

• Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group.

  Maini R. et al, (1999), Lancet (London, England), 354, 1932 - 1939

• The role of cytokines in the pathogenesis of rheumatoid arthritis.

  Feldmann M. and Maini RN., (1999), Rheumatology (Oxford, England), 38 Suppl 2, 3 - 7

• The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?

  Feldmann M. et al, (1999), Annals of the rheumatic diseases, 58 Suppl 1, I27 - I31

• Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool.

  Webb LM. et al, (1999), Immunology, 98, 400 - 405

• Combination therapy with DMARDs and biological agents in collagen-induced arthritis.

  Williams RO. et al, (1999), Clinical and experimental rheumatology, 17, S115 - S120

• Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.

  Maini RN. et al, (1999), Annals of the rheumatic diseases, 58 Suppl 1, I56 - I60

• Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease.

  Giovannoni G. et al, (1999), Multiple sclerosis (Houndmills, Basingstoke, England), 5, 335 - 341

• Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

  Charles P. et al, (1999), Journal of immunology (Baltimore, Md. : 1950), 163, 1521 - 1528

• CD44 involvement in experimental collagen-induced arthritis (CIA).

  Nedvetzki S. et al, (1999), Journal of autoimmunity, 13, 39 - 47

• Therapeutic antibodies elicited by immunization against TNF-alpha.

  Dalum I. et al, (1999), Nature biotechnology, 17, 666 - 669

• Paradoxical effects of adenovirus-mediated blockade of TNF activity in murine collagen-induced arthritis.

  Quattrocchi E. et al, (1999), Journal of immunology (Baltimore, Md. : 1950), 163, 1000 - 1009

• Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.

  Butler DM. et al, (1999), European journal of immunology, 29, 2205 - 2212

• The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.

  Malfait AM. et al, (1999), Journal of immunology (Baltimore, Md. : 1950), 162, 6278 - 6283

• Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

  Bondeson J. et al, (1999), Proceedings of the National Academy of Sciences of the United States of America, 96, 5668 - 5673

• Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.

  Bondeson J. et al, (1999), Journal of immunology (Baltimore, Md. : 1950), 162, 2939 - 2945

• The murine p75 TNF receptor promoter region: DNA sequence and characterization of a cis-acting silencer.

  Kissonerghis M. et al, (1999), Molecular immunology, 36, 125 - 134

• Potentiation of TNF-alpha toxicity by conjugation with ricin A-chain.

  Gould DJ. et al, (1998), Cytokine, 10, 931 - 939

• Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis.

  Croxford JL. et al, (1998), European journal of immunology, 28, 3904 - 3916

• Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy.

  Williams RO. et al, (1998), Arthritis and rheumatism, 41, 1806 - 1812

• Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.

  Maini RN. et al, (1998), Arthritis and rheumatism, 41, 1552 - 1563

• Minimal tumor necrosis factor receptor binding protein: optimum biological activity of a truncated p55 soluble tumor necrosis factor receptor-IgG fusion protein.

  Corcoran AE. et al, (1998), European cytokine network, 9, 255 - 262

• An anti-inflammatory role for interleukin-11 in established murine collagen-induced arthritis.

  Walmsley M. et al, (1998), Immunology, 95, 31 - 37

• Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.

  Hermann JA. et al, (1998), Arthritis and rheumatism, 41, 1388 - 1397

• Human macrophages induced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production.

  Smith W. et al, (1998), European journal of immunology, 28, 2498 - 2507

• Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis.

  Paleolog EM. et al, (1998), Arthritis and rheumatism, 41, 1258 - 1265

• Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.

  Foxwell B. et al, (1998), Proceedings of the National Academy of Sciences of the United States of America, 95, 8211 - 8215

• IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.

  Sanz MJ. et al, (1998), Journal of immunology (Baltimore, Md. : 1950), 160, 5637 - 5645

• Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA-cationic liposome complex into the central nervous system.

  Croxford JL. et al, (1998), Journal of immunology (Baltimore, Md. : 1950), 160, 5181 - 5187

• Similarities in the mechanisms of action of pulse corticosteroids and anti-tumor necrosis factor alpha therapy in rheumatoid arthritis - Reply

  Maini RN. and Feldmann M., (1998), ARTHRITIS AND RHEUMATISM, 41, 565 - 565

• Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.

  Malfait AM. et al, (1998), Clinical and experimental immunology, 111, 377 - 383

• Role of pro-inflammatory cytokines in rheumatoid arthritis.

  Brennan FM. et al, (1998), Springer seminars in immunopathology, 20, 133 - 147

• Rheumatoid arthritis: introduction.

  Feldmann M. and Maini RN., (1998), Springer seminars in immunopathology, 20, 3 - 4

• Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

  Foey AD. et al, (1998), Journal of immunology (Baltimore, Md. : 1950), 160, 920 - 928

• Cytokines in autoimmune disorders.

  Feldmann M. et al, (1998), International reviews of immunology, 17, 217 - 228

• Biological insights from clinical trials with anti-TNF therapy.

  Feldmann M. et al, (1998), Springer seminars in immunopathology, 20, 211 - 228

• Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.

  Ross SE. et al, (1997), Journal of immunology (Baltimore, Md. : 1950), 159, 6253 - 6259

• Suppression of collagen-induced arthritis by continuous administration of IL-4.

  Horsfall AC. et al, (1997), Journal of immunology (Baltimore, Md. : 1950), 159, 5687 - 5696

• Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways.

  Sanz MJ. et al, (1997), Blood, 90, 4144 - 4152

• Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2.

  Cohen SB. et al, (1997), Immunology, 92, 1 - 5

• DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.

  Butler DM. et al, (1997), Journal of immunology (Baltimore, Md. : 1950), 159, 2867 - 2876

• Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action.

  Feldmann M. et al, (1997), European cytokine network, 8, 297 - 300

• Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade.

  Davis D. et al, (1997), British journal of rheumatology, 36, 950 - 956

• Selective enhancement of endothelial cell VCAM-1 expression by interleukin-10 in the presence of activated leucocytes.

  Fiehn C. et al, (1997), Immunology, 91, 565 - 571

• Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.

  Brennan FM. et al, (1997), British journal of rheumatology, 36, 643 - 650

• Longitudinal study of soluble adhesion molecules in multiple sclerosis: correlation with gadolinium enhanced magnetic resonance imaging.

  Giovannoni G. et al, (1997), Neurology, 48, 1557 - 1565

• Autocrine and paracrine regulation of human T cell IL-10 production.

  Cohen SB. et al, (1997), Journal of immunology (Baltimore, Md. : 1950), 158, 5596 - 5602

• Effect of blocking TNF on IL-6 levels and metastasis in a B16-BL6 melanoma/mouse model.

  Cubillos S. et al, (1997), Anticancer research, 17, 2207 - 2211

• TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.

  Maini RN. et al, (1997), APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 105, 257 - 263

• Role of tyrosine kinase enzymes in TNF-alpha and IL-1 induced expression of ICAM-1 and VCAM-1 on human umbilical vein endothelial cells.

  Majewska E. et al, (1997), Scandinavian journal of immunology, 45, 385 - 392

• Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.

  Parry SL. et al, (1997), Journal of immunology (Baltimore, Md. : 1950), 158, 3673 - 3681

• Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.

  Webb LM. et al, (1997), European journal of immunology, 27, 633 - 640

• Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).

  Marinova-Mutafchieva L. et al, (1997), Clinical and experimental immunology, 107, 507 - 512

• Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis.

  Sebbag M. et al, (1997), European journal of immunology, 27, 624 - 632

• Daily urinary neopterin excretion as an immunological marker of disease activity in multiple sclerosis.

  Giovannoni G. et al, (1997), Brain, 120 ( Pt 1), 1 - 13

• Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis.

  Feldmann M. et al, (1997), Advances in immunology, 64, 283 - 350

• What is the mechanism of action of anti-tumour necrosis factor-alpha antibody in rheumatoid arthritis?

  Feldmann M., (1996), International archives of allergy and immunology, 111, 362 - 365

• Cytokines in autoimmunity.

  Brennan FM. and Feldmann M., (1996), Current opinion in immunology, 8, 872 - 877

• The cytokine network in rheumatoid arthritis: definition of TNF alpha as a therapeutic target.

  Feldmann M., (1996), Journal of the Royal College of Physicians of London, 30, 560 - 570

• The role of receptors for tumour necrosis factor-alpha in the induction of human polymorphonuclear neutrophil chemiluminescence.

  Zeman K. et al, (1996), Immunology letters, 53, 45 - 50

• Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.

  Webb LM. et al, (1996), European journal of immunology, 26, 2320 - 2328

• Increased urinary neopterin excretion in vaccinated adults

  Giovannoni G. et al, (1996), PTERIDINES, 7, 82 - 86

• Cytokine therapy in rheumatoid arthritis.

  Maini RN. and Feldmann M., (1996), Lancet (London, England), 348, 824 - 825

• Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis.

  Mauri C. et al, (1996), European journal of immunology, 26, 1511 - 1518

• Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.

  Paleolog EM. et al, (1996), Arthritis and rheumatism, 39, 1082 - 1091

• Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.

  Williams LM. et al, (1996), The Journal of clinical investigation, 97, 2833 - 2841

• Rheumatoid arthritis.

  Feldmann M. et al, (1996), Cell, 85, 307 - 310

• Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist.

  Neve R. et al, (1996), Cytokine, 8, 365 - 370

• The method of deriving human T-cell clones alters the proportion of IL-10-producing cells.

  Cohen SB. et al, (1996), Immunology, 87, 343 - 347

• Interleukin-10 inhibition of the progression of established collagen-induced arthritis.

  Walmsley M. et al, (1996), Arthritis and rheumatism, 39, 495 - 503

• Humoral and cellular responses raised against the human HER2 oncoprotein are cross-reactive with the homologous product of the new proto-oncogene, but do not protect rats against B104 tumors expressing mutated neu.

  Taylor P. et al, (1996), Cancer immunology, immunotherapy : CII, 42, 179 - 184

• T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10.

  Brookes SM. et al, (1996), Clinical and experimental immunology, 103, 268 - 272

• Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.

  Quaratino S. et al, (1996), The Journal of experimental medicine, 183, 349 - 358

• Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions.

  Norman KE. et al, (1996), British journal of pharmacology, 117, 471 - 478

• Soluble E-selectin in multiple sclerosis: raised concentrations in patients with primary progressive disease.

  Giovannoni G. et al, (1996), Journal of Neurology, Neurosurgery, and Psychiatry, 60, 20 - 26

• Role of cytokines in rheumatoid arthritis.

  Feldmann M. et al, (1996), Annual review of immunology, 14, 397 - 440

• Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor.

  Chernajovsky Y. et al, (1995), Gene therapy, 2, 731 - 735

• Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.

  Scallon BJ. et al, (1995), Cytokine, 7, 759 - 770

• Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.

  Webb LM. and Feldmann M., (1995), Blood, 86, 3479 - 3486

• Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells.

  Clarke CJ. et al, (1995), European journal of immunology, 25, 2961 - 2966

• TNF alpha is an effective therapeutic target for rheumatoid arthritis.

  Feldmann M. et al, (1995), Annals of the New York Academy of Sciences, 766, 272 - 278

• Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)

  Maini RN. et al, (1995), Clinical and experimental immunology, 101, 207 - 212

• Are CD4+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-gamma or IL-2 determines their function.

  Katsikis PD. et al, (1995), International immunology, 7, 1287 - 1294

• TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.

  Brennan FM. et al, (1995), Scandinavian journal of immunology, 42, 158 - 165

• Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1 alpha and IL-1 receptor antagonist.

  Phillips WG. et al, (1995), Clinical and experimental immunology, 101, 177 - 182

• Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.

  Butler DM. et al, (1995), European cytokine network, 6, 225 - 230

• Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines.

  Mullins RJ. et al, (1995), The Journal of clinical investigation, 96, 30 - 37

• High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane.

  Cohen SB. et al, (1995), Arthritis and rheumatism, 38, 946 - 952

• Comparison of peptide and superantigen-induced anergy in a peptide-specific polyclonal human T cell line.

  Chu NR. et al, (1995), International immunology, 7, 1057 - 1063

• Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.

  Maini RN. et al, (1995), Immunological reviews, 144, 195 - 223

• Human alpha beta T-cell receptor CD4-CD8 T-cell clones are predominantly Th0-like.

  Katsikis PD. et al, (1995), Immunology, 84, 501 - 504

• Gene therapy of rheumatoid arthritis via cytokine regulation: future perspectives.

  Chernajovsky Y. et al, (1995), British medical bulletin, 51, 503 - 516

• Cytokine expression in chronic inflammatory disease.

  Brennan FM. et al, (1995), British medical bulletin, 51, 368 - 384

• Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.

  Williams RO. et al, (1995), Immunology, 84, 433 - 439

• TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action.

  Elliott MJ. et al, (1995), International journal of immunopharmacology, 17, 141 - 145

• Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.

  Cope AP. et al, (1995), Immunology, 84, 21 - 30

• Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.

  Brennan FM. et al, (1995), Chemical immunology, 60, 48 - 60

• LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.

  Weg VB. et al, (1995), Immunology, 84, 36 - 40

• Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action.

  Feldmann M. et al, (1995), Journal of inflammation, 47, 90 - 96

• Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes.

  Joyce DA. et al, (1994), European journal of immunology, 24, 2699 - 2705

• TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.

  Butler DM. et al, (1994), Cytokine, 6, 616 - 623

• Targeting TNF alpha for the therapy of rheumatoid arthritis.

  Maini RN. et al, (1994), Clinical and experimental rheumatology, 12 Suppl 11, S63 - S66

• IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.

  Cohen SB. et al, (1994), Immunology, 83, 329 - 332

• Use of anti-tumor necrosis factor antibodies in rheumatoid arthritis.

  Feldmann M. et al, (1994), Journal of interferon research, 14, 299 - 300

• Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis.

  Elliott MJ. et al, (1994), Lancet (London, England), 344, 1125 - 1127

• Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.

  Elliott MJ. et al, (1994), Lancet (London, England), 344, 1105 - 1110

• Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells.

  Paleolog EM. et al, (1994), Blood, 84, 2578 - 2590

• p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.

  Butler DM. et al, (1994), European cytokine network, 5, 441 - 448

• Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins.

  Baker D. et al, (1994), European journal of immunology, 24, 2040 - 2048

• TNF alpha as a therapeutic target in rheumatoid arthritis.

  Feldmann M. et al, (1994), Circulatory shock, 43, 179 - 184

• Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.

  Gibbons DL. et al, (1994), European journal of immunology, 24, 1879 - 1885

• Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.

  Cope AP. et al, (1994), The Journal of clinical investigation, 94, 749 - 760

• Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.

  Corcoran AE. et al, (1994), European journal of biochemistry, 223, 831 - 840

• Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells.

  Mullins RJ. et al, (1994), Journal of immunology (Baltimore, Md. : 1950), 152, 5572 - 5580

• Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

  Katsikis PD. et al, (1994), The Journal of experimental medicine, 179, 1517 - 1527

• Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.

  Williams RO. et al, (1994), Proceedings of the National Academy of Sciences of the United States of America, 91, 2762 - 2766

• Selective activation of blood T cells in children with newly diagnosed insulin dependent diabetes mellitus.

  Kontiainen S. et al, (1994), Autoimmunity, 19, 63 - 66

• Prospects for cytokines in human immunotherapy

  Haworth C. et al, (1994), The Cytokine Handbook, 461 - 487

• Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.

  Maini RN. et al, (1994), Springer seminars in immunopathology, 16, 327 - 336

• From the laboratory to the clinic: Evaluation of cytokines in rheumatoid arthritis highlights TNF-alpha as a new therapeutic target

  Feldmann M. et al, (1994), Immunologist, 2, 172 - 176

• Erratum: c-erbB-2 Oncoprotein in screen-detected breast carcinoma: An immunohistological study (International Journal of Cancer (1993) 55 (63-65))

  Soomro S. et al, (1994), International Journal of Cancer, 56

• Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.

  Elliott MJ. et al, (1993), Arthritis and rheumatism, 36, 1681 - 1690

• Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.

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• Antilipid A monoclonal antibody HA-1A decreases the capacity of bacterial lipopolysaccharide to activate human vascular endothelial cells by an immune adherence mechanism.

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• T-cell activation in health and disease.

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• Understanding what infiltrating cells do in autoimmunity: combination of cellular and molecular approaches.

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• Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.

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• Analysis of endocrine autoimmunity by cloning human T lymphocytes from target tissues

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• Thyrocytes can synthesize HLA class II molecules.

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• Interferons and autoimmunity.

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• Comparison of the cellular infiltrate of Hashimoto's thyroiditis in vivo and after in vitro cell growth.

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• Derivation of ganglioside-specific T cell lines of suppressor or helper phenotype from cerebrospinal fluid of multiple sclerosis patients.

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• The relationship between secreted and cell surface antigen-binding molecules synthesized by T cells. I. Function-related isotypic determinants on T cells defined by antisera to antigen-specific helper and suppressor factors.

  Culbert EJ. et al, (1984), Immunology, 53, 481 - 490

• Mechanism of action of immune response genes.

  Feldmann M., (1984), Annales d'immunologie, 135C, 402 - 407

• Clonal approaches to immune regulation by lymphocytes.

  Feldmann M. and Lamb JR., (1984), Behring Institute Mitteilungen, 149 - 156

• [A change in the expression of histocompatibility antigens could lead to autoimmunity]

  Pujol-Borrell R. et al, (1984), Medicina clinica, 82, 594 - 595

• Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction.

  Lamb JR. and Feldmann M., (1984), Nature, 308, 72 - 74

• Inhibition of T cell proliferation by antibodies to synthetic peptides.

  Lamb JR. et al, (1984), European journal of immunology, 14, 153 - 157

• The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.

  Lamb JR. et al, (1983), Immunology, 50, 397 - 405

• Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity.

  Bottazzo GF. et al, (1983), Lancet (London, England), 2, 1115 - 1119

• Tolerance of T-cell clones is associated with membrane antigen changes.

  Zanders ED. et al, (1983), Nature, 303, 625 - 627

• Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

  Lamb JR. et al, (1983), The Journal of experimental medicine, 157, 1434 - 1447

• Antigen-specific and non-specific helper activities derived from supernatants of human influenza virus-specific T-cell lines.

  Zanders ED. et al, (1983), Immunology, 48, 361 - 366

• Induction of a T-cell mediated suppressor activity by soluble products from antigen-specific helper/inducer human T-cell lines.

  Fischer A. et al, (1983), Immunology, 48, 177 - 186

• A monoclonal antibody against antigen-specific helper factor augments T-cell help.

  James RF. et al, (1983), Nature, 301, 160 - 163

• A human suppressor T cell clone which recognizes an autologous helper T cell clone.

  Lamb JR. and Fledmann M., (1982), Nature, 300, 456 - 458

• An influenza virus matrix protein-specific human T cell line with helper activity for in vitro anti-hemagglutinin antibody production.

  Fischer A. et al, (1982), European journal of immunology, 12, 844 - 849

• Specific suppression of antibody responses in vivo. I. Effects of in vitro produced suppressor factor.

  Kontiainen S. et al, (1982), Immunology, 45, 459 - 465

• Structure of antigen-specific suppressor factors: current views.

  Kontiainen SK. et al, (1982), Survey of immunologic research, 1, 17 - 23

• Ia and macrophages in alloproliferation and allocytotoxicity.

  Katz DR. et al, (1982), Advances in experimental medicine and biology, 155, 601 - 609

• Genetically restricted and unrestricted antigen specific helper factors

  Feldmann M. et al, (1982), Behring Institute Mitteilungen, No. 70, 196 - 199

• Definition of function-related isotypic markers on T cells.

  Culbert EJ. et al, (1982), Current topics in microbiology and immunology, 100, 19 - 32

• A comparative study of accessory cells derived from the peritoneum and from solid tissues.

  Katz DR. et al, (1982), Advances in experimental medicine and biology, 149, 421 - 428

• Long-term human T-helper lines producing specific helper factor reactive to influenza virus.

  Fischer A. et al, (1981), Nature, 294, 166 - 168

• T-cell hybridomas producing hapten-specific suppressor factors.

  Kontiainen S. et al, (1981), Immunology, 43, 747 - 754

• Antigen-specific helper factor reacts with antibodies to human beta 2 microglobulin.

  Lamb JR. et al, (1981), Journal of immunology (Baltimore, Md. : 1950), 127, 231 - 234

• Genetics of human T cell-monocyte interaction in helper cell induction.

  Rees A. et al, (1981), Clinical and experimental immunology, 44, 445 - 452

• Nature of macrophage-T cell interaction in secondary helper cell generation in vitro. Genetic restriction of macrophage-T cell interaction, which determines T-B genetic restriction.

  Vogt P. et al, (1981), European journal of immunology, 11, 377 - 381

• Induction of human antigen-specific suppressor factors in vitro.

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• Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.

  Sunshine GH. et al, (1980), The Journal of experimental medicine, 152, 1817 - 1822

• Nature of T cell-macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host.

  Erb P. et al, (1980), Journal of immunology (Baltimore, Md. : 1950), 124, 2656 - 2664

• Specific T helper and suppressor cells and factors induced in vitro to the hapten NP.

  Kontiainen S. and Feldmann M., (1980), Annales d'immunologie, 131C, 239 - 255

• Antigen specific T cell factors.

  Feldmann M. and Kontiainen S., (1980), Molecular and cellular biochemistry, 30, 177 - 193

• Antibody production to antigen-specific factors.

  Feldmann M. et al, (1980), Contemporary topics in immunobiology, 11, 275 - 289

• Structural characteristics of antigen-specific suppressor factors: definition of 'constant' region and 'variable' region determinants.

  Kontiainen S. and Feldmann M., (1979), Thymus, 1, 59 - 79

• Selective production of human antigen specific helper factor from normal volunteers: implications for human Ir genes.

  Zvaifler NJ. et al, (1979), Clinical and experimental immunology, 37, 328 - 338

• Induction of antibody responses in vivo by antigen specific helper factor.

  Woody JN. et al, (1979), Immunobiology, 156, 13 - 24

• Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).

  Howie S. et al, (1979), European journal of immunology, 9, 501 - 506

• Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?

  Erb P. et al, (1979), Journal of immunology (Baltimore, Md. : 1950), 122, 1916 - 1919

• Induction of human antigen-specific and non-specific helper factors in vitro.

  Kantor F. and Feldmann M., (1979), Clinical and experimental immunology, 36, 71 - 77

• Nature of T-cell macrophage interaction in helper-cell induction in vitro. II. Two stages of T-helper-cell differentiation analyzed in irradiation and allophenic chimeras.

  Erb P. et al, (1979), The Journal of experimental medicine, 149, 686 - 701

• MLC and CMC reactivity and specificity of idiotype-specific lymphoid cells enriched for histocompatibility (H-2) antigens.

  Folks TM. et al, (1979), Transplantation proceedings, 11, 683 - 689

• Human and mouse specific T-cell helper factors assayed in vivo and in vitro: implications for human Ir genes.

  Woody JN. et al, (1979), Transplantation proceedings, 11, 382 - 388

• Suppressor cell induction in vitro. VI. Production of suppressor factors to synthetic polypeptides GAT and (T,G)-A--L from cells of responder and nonresponder mice.

  Kontianen S. et al, (1979), Journal of immunology (Baltimore, Md. : 1950), 122, 253 - 259

• Macrophage-lymphocyte interactions in immune induction.

  Feldmann M. et al, (1979), International review of cytology, 60, 149 - 178

• Human T-cell responses in vitro: cell interactions and factors.

  Rees A. et al, (1979), Annals of the New York Academy of Sciences, 332, 503 - 515

• Comparison of antigen-specific I-region-associated cell interaction factors.

  Feldmann M. et al, (1979), Annals of the New York Academy of Sciences, 332, 591 - 604

• Cellular interactions in antibody production

  Howie S. and Feldmann M., (1978), Clinics in Rheumatic Diseases, 4, 481 - 498

• Nature of T cell-macrophage interaction in helper cell induction in vitro. I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming.

  Erb P. et al, (1978), European journal of immunology, 8, 786 - 792

• T-cell lines producing antigen-specific suppressor factor.

  Kontiainen S. et al, (1978), Nature, 274, 477 - 480

• Immune response (Ir) genes expressed at macrophage-B lymphocyte interactions.

  Howie S. and Feldmann M., (1978), Nature, 273, 664 - 666

• Cellular basis of the humoral immune response in mouse and hamster.

  Erb P. et al, (1978), Federation proceedings, 37, 2032 - 2034

• T cell hybrids with T cell functions.

  Simpson E. et al, (1978), Current topics in microbiology and immunology, 81, 195 - 202

• Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships.

  Kontiainen S. and Feldmann M., (1978), The Journal of experimental medicine, 147, 110 - 122

• Complexity of cell interactions: analysis using antigens under Ir gene control.

  Baltz M. et al, (1978), Advances in experimental medicine and biology, 98, 325 - 338

• COMPLEMENTATION OF H-2-LINKED IR GENES - USE OF HELPER FACTOR TO ANALYZE RESPONSES TO GLYPHE

  BALTZ M. et al, (1978), IMMUNOGENETICS, 6, 471 - 481

• Requirement for interactions between two subpopulations of T cells for helper cell induction in vitro.

  Feldmann M. and Erb P., (1977), Zeitschrift fur Immunitatsforschung. Immunobiology, 153, 217 - 225

• The role of macrophages in the generation of T helper cells. V. Evidence for differential activation of short-lived T1 and long-lived T2 lymphocytes by the macrophage factors GRF and NMF.

  Erb P. et al, (1977), Journal of immunology (Baltimore, Md. : 1950), 119, 206 - 209

• In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.

  Howie S. and Feldman M., (1977), European journal of immunology, 7, 417 - 421

• Suppressor cell induction in vitro. III. Antigen-specific suppression by supernatants of suppressor cells.

  Kontianinen S. and Feldmann M., (1977), European journal of immunology, 7, 310 - 314

• Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells.

  Woody JN. et al, (1977), Journal of immunology (Baltimore, Md. : 1950), 118, 1739 - 1743

• Are the Ir genes expressed by macrophages?

  Feldmann M., (1977), Nature, 267

• T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

  Feldmann M. et al, (1977), The Journal of experimental medicine, 145, 793 - 801

• In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.

  Howie S. et al, (1977), Immunology, 32, 291 - 299

• Antigenic phenotypes of T-cell subsets.

  Beverley PC. et al, (1977), Transplantation proceedings, 9, 703 - 704

• INVITRO STUDIES ON H-2 LINKED UNRESPONSIVENESS .1. NORMAL HELPER CELLS TO (T,G)-A-L AND GAT IN LOW AND NON-RESPONDER MICE

  HOWIE S. et al, (1977), IMMUNOLOGY, 32, 291 - 299

• Current concepts of the antibody response: heterogeneity of lymphoid cells, interactions, and factors.

  Feldmann M. et al, (1977), Cold Spring Harbor symposia on quantitative biology, 41 Pt 1, 113 - 118

• Two-gene control of T-helper cell induction.

  Erb P. et al, (1976), Nature, 263, 601 - 604

• Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.

  Desaymard C. et al, (1976), European journal of immunology, 6, 646 - 650

• Separation of suppressor and killer T cells by surgace phenotype.

  Beverley PC. et al, (1976), Nature, 262, 495 - 497

• Immunological effects of IgT synthesized by theta-positive cell lines.

  Feldmann M. et al, (1976), European journal of immunology, 5, 429 - 431

• Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens.

  Erb P. et al, (1976), European journal of immunology, 6, 365 - 372

• Mechanisms of B-cell tolerance.

  Klaus GG. et al, (1976), British medical bulletin, 32, 141 - 146

• Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.

  Kontiainen S. and Feldmann M., (1976), European journal of immunology, 6, 296 - 301

• Suppressor cell induction in vitro. II. Cellular requirements of suppressor cell induction.

  Feldmann M. and Kontiainen S., (1976), European journal of immunology, 6, 302 - 305

• Secondary cytotoxic allograft responses in vitro. III. The immunogenicity of allogeneic membrane fragments.

  Wagner H. et al, (1976), Transplantation, 21, 282 - 288

• Enrichment of antigen-specific helper and suppressor T cells.

  Maoz A. et al, (1976), Nature, 260, 324 - 327

• Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.

  Feldmann M. et al, (1975), Nature, 258, 614 - 616

• The role of macrophages in the generation of T helper cells. III. Influence of macrophage-derived factors in helper cell induction.

  Erb P. and Feldmann M., (1975), European journal of immunology, 5, 759 - 766

• The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.

  Erb P. and Feldmann M., (1975), Cellular immunology, 19, 356 - 367

• The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

  Erb P. and Feldmann M., (1975), The Journal of experimental medicine, 142, 460 - 472

• T-T interaction in the generation of helper cells in vitro.

  Feldmann M. et al, (1975), Nature, 256, 741 - 743

• Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. I. Studies with 2,4-dinitrophenyl conjugates in vitro.

  Desaymard C. and Feldmann M., (1975), European journal of immunology, 5, 537 - 541

• B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.

  Gorczynski RM. and Feldmann M., (1975), Cellular immunology, 18, 88 - 97

• Role of macrophages in in vitro induction of T-helper cells.

  Erb P. and Feldmann M., (1975), Nature, 254, 352 - 354

• Lack of requirement for cell cooperation in the antibody response to DNP conjugated to levan.

  Desaymard C. and Feldmann M., (1975), Cellular immunology, 16, 106 - 114

• Role of T-cell immunoglobulin in cell cooperation, T-cell suppression, and antigenic competition.

  Feldmann M. et al, (1975), Annals of the New York Academy of Sciences, 249, 424 - 437

• Role of antigen structure in the discrimination between tolerance and immunity by b cells.

  Feldmann M. et al, (1975), Transplantation reviews, 23, 78 - 97

• Conditions for inducing T helper cells in vitro.

  Kontiainen S. and Feldmann M., (1975), Scandinavian journal of immunology, 4, 121 - 128

• Tolerance induction to a hapten protein conjugate in vivo: are suppressor T cells involved.

  Huchet R. and Feldmann M., (1974), European journal of immunology, 4, 768 - 771

• Mechanism of antigenic competition. II. Induction by specific T cell products.

  Feldmann M. and Schrader JW., (1974), Cellular immunology, 14, 255 - 269

• T cell suppression in vitro. II. Nature of specific suppressive factor.

  Feldmann M., (1974), European journal of immunology, 4, 667 - 674

• T cell suppression in vitro. I. Role in regulation of antibody responses.

  Feldmann M., (1974), European journal of immunology, 4, 660 - 666

• Direct triggering of B lymphocytes by insolubilized antigen.

  Feldmann M. et al, (1974), European journal of immunology, 4, 591 - 597

• The effect of erythrocyte antigen structure on requirement for T cells.

  Byrd W. et al, (1974), Immunology, 27, 331 - 337

• Role of C3 in in vitro lymphocyte cooperation.

  Feldmann M. and Pepys MB., (1974), Nature, 249, 159 - 161

• Thymus-independent IgM and IgG responses in mice to flagellar antigens.

  Huchet R. and Feldmann M., (1974), International archives of allergy and applied immunology, 46, 600 - 611

• Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes.

  Cone RE. et al, (1974), Immunology, 26, 49 - 60

• Cell to cell interactions in the immune response.

  Feldmann M., (1974), Series haematologica (1968), 7, 593 - 609

• Synergy among thymocytes and peripheral lymph node cells in the in vitro generation of lymphocytes cytotoxic to alloantigens.

  Tigelaar RE. and Feldmann M., (1973), Transplantation proceedings, 5, 1711 - 1715

• Histocompatibility-linked immune-response genes. What do they do?

  Feldmann M., (1973), Transplantation proceedings, 5, 1803 - 1809

• The mechanism of antigenic competition. I. The macrophage as a site of a reversible block of T-B lymphocyte collaboration.

  Schrader JW. and Feldmann M., (1973), European journal of immunology, 3, 711 - 717

• Relative affinity and avidity of the antigen-binding receptors of T and B rosette-forming cells.

  Wilson JD. and Feldmann M., (1973), Nature: New biology, 245, 177 - 180

• Induction of specific helper cells in vitro.

  Kontianen S. and Feldmann M., (1973), Nature: New biology, 245, 285 - 286

• Cell interactions in the immune response in vitro. VI. Mediation by T cell surface monomeric IgM.

  Feldmann M. et al, (1973), Cellular immunology, 9, 1 - 11

• Monospecificity of bone marrow-derived lymphocytes.

  Raff MC. et al, (1973), The Journal of experimental medicine, 137, 1024 - 1030

• Role of T-cell antigen-specific factor in T-B cooperation.

  Feldmann M., (1973), Transplantation proceedings, 5, 111 - 114

• Induction fo B cell tolerance by antigen specific T cell factor.

  Feldman M., (1973), Nature: New biology, 242, 82 - 84

• Cellular components of the immune system and their cooperation (T and B cells).

  Feldmann M., (1973), Transplantation proceedings, 5, 43 - 48

• The role of soluble factors in T-B cell collaboration.

  Basten A. and Feldmann M., (1973), Advances in experimental medicine and biology, 29, 171 - 178

• Studies on antibody affinity in mice.

  Huchet R. and Feldmann M., (1973), European journal of immunology, 3, 49 - 55

• Mechanism of antigen binding to receptor antibody in B cell immunity and tolerance in vitro.

  Feldmann M., (1973), Advances in experimental medicine and biology, 29, 363 - 368

• Humoral and cell mediated responses in vitro of spleen cells from mice with thymic aplasia (nude mice).

  Feldmann M. et al, (1972), The Australian journal of experimental biology and medical science, 50, 651 - 660

• Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.

  Feldmann M., (1972), The Journal of experimental medicine, 136, 737 - 760

• Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.

  Feldmann M. and Basten A., (1972), The Journal of experimental medicine, 136, 722 - 736

• Mechanisms at the cellular level during induction of high zone tolerance in vitro.

  Diener E. and Feldmann M., (1972), Cellular immunology, 5, 130 - 136

• Induction of immunity and tolerance in vitro by hapten protein conjugates. 3. Hapten inhibition studies of antigen binding to B cells in immunity and tolerance.

  Feldmann M., (1972), The Journal of experimental medicine, 136, 532 - 545

• Cellular basis of antibody production.

  Feldmann M. and Nossal GJ., (1972), The Quarterly review of biology, 47, 269 - 302

• Cell-mediated immune response in vitro. 3. The requirement for macrophages in cytotoxic reactions against cell-bound and subcellular alloantigens.

  Wagner H. et al, (1972), The Journal of experimental medicine, 136, 331 - 343

• Cell interactions in the immune response in vitro. 3. Specific collaboration across a cell impermeable membrane.

  Feldmann M. and Basten A., (1972), The Journal of experimental medicine, 136, 49 - 67

• Cell interactions in the immune response in vitro. I. Metabolic activities of T cells in a collaborative antibody response.

  Feldmann M. and Basten A., (1972), European journal of immunology, 2, 213 - 224

• Specific collaboration between T and B lymphocytes across a cell impermeable membrane in vitro.

  Feldmann M. and Basten A., (1972), Nature: New biology, 237, 13 - 15

• Dynamic aspects of antigen binding to B cells in immune induction.

  Wilson JD. and Feldmann M., (1972), Nature: New biology, 237, 3 - 5

• Cell-mediated immune response in vitro. II. The role of thymus and thymus-derived lymphocytes.

  Wagner H. et al, (1972), Cellular immunology, 4, 39 - 50

• Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration.

  Feldmann M., (1972), The Journal of experimental medicine, 135, 1049 - 1058

• Induction of immunity and tolerance in vitro by hapten protein conjugates. I. The relationship between the degree of hapten conjugation and the immunogenicity of dinitrophenylated polymerized flagellin.

  Feldmann M., (1972), The Journal of experimental medicine, 135, 735 - 753

• Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin.

  Feldmann M., (1972), European journal of immunology, 2, 130 - 137

• Cell-mediated immune response in vitro. I. A new in vitro system for the generation of cell-mediated cytotoxic activity.

  Wagner H. and Feldmann M., (1972), Cellular immunology, 3, 405 - 420

• Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages.

  Feldmann M. and Nossal GJ., (1972), Transplantation reviews, 13, 3 - 34

• The detection of autoantibody-forming cells. I. An assay for plaque-forming cells to the basic protein of myelin in guinea-pigs.

  Lennon V. and Feldmann M., (1972), International archives of allergy and applied immunology, 42, 627 - 640

• The detection of autoantibody-forming cells. II. Cells in lymph nodes and central nervous system containing antibody to myelin basic protein.

  Lennon V. et al, (1972), International archives of allergy and applied immunology, 43, 749 - 758

• Relationship between antigen and antibody-induced suppression of immunity.

  Diener E. and Feldmann M., (1972), Transplantation reviews, 8, 76 - 103

• Antibody-mediated suppression of the immune response in vitro. IV. The effect of antibody fragments.

  Feldmann M. and Diener E., (1972), Journal of immunology (Baltimore, Md. : 1950), 108, 93 - 101

• The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro.

  Feldmann M. and Palmer J., (1971), Immunology, 21, 685 - 699

• Antibody-mediated suppression of the immune response in vitro. 3. Low zone tolerance in vitro.

  Feldmann M. and Diener E., (1971), Immunology, 21, 387 - 404

• The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

  Feldmann M. and Easten A., (1971), The Journal of experimental medicine, 134, 103 - 119

• Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro.

  Feldmann M. and Diener E., (1971), Nature: New biology, 231, 183 - 184

• Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

  Feldmann M., (1971), Nature: New biology, 231, 21 - 23

• Induction of low-zone tolerance in vitro.

  Diener E. and Feldmann M., (1971), Transplantation proceedings, 3, 663 - 665

• Antibody-mediated suppression of the immune response in vitro. II. A new approach to the phenomenon of immunological tolerance.

  Diener E. and Feldmann M., (1970), The Journal of experimental medicine, 132, 31 - 43

• Antibody-mediated suppression of the immune response in vitro. I. Evidence for a central effect.

  Feldmann M. and Diener E., (1970), The Journal of experimental medicine, 131, 247 - 274

• Assemblée générale du 13 Mars 1970

  (1970), Bulletin de la Société Botanique de France, 117, 177 - 177

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