Sir Marc Feldmann FRS

• Anti-TNF Therapy.

  Journal article

  Udalova I. et al, (2016), Microbiology spectrum, 4

• Macrophage heterogeneity in the context of rheumatoid arthritis.

  Journal article

  Udalova IA. et al, (2016), Nature reviews. Rheumatology, 12, 472 - 485

• Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

  Journal article

  Cole JE. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 13033 - 13038

• Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

  Journal article

  Cribbs A. et al, (2015), Therapeutic advances in musculoskeletal disease, 7, 206 - 219

• IRF5 controls both acute and chronic inflammation.

  Journal article

  Weiss M. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 11001 - 11006

• IRF5 controls both acute and chronic inflammation

  Journal article

  Weiss M. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 11001 - 11006

• Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.

  Journal article

  Espirito Santo AI. et al, (2015), Biochemical and biophysical research communications, 464, 1145 - 1150

• Perspectives From Masters in Rheumatology and Autoimmunity: Can We Get Closer to a Cure for Rheumatoid Arthritis?

  Journal article

  Feldmann M. and Maini RN., (2015), Arthritis & rheumatology (Hoboken, N.J.), 67, 2283 - 2291

• Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.

  Journal article

  Chan JK. et al, (2015), EMBO molecular medicine, 7, 547 - 561

• Preclinical target validation using patient-derived cells.

  Journal article

  Edwards AM. et al, (2015), Nature reviews. Drug discovery, 14, 149 - 150

• Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

  Journal article

  Terrando N. et al, (2015), Molecular Medicine, 20, 667 - 675

• Anti-TNF therapy: past, present and future.

  Journal article

  Monaco C. et al, (2015), International immunology, 27, 55 - 62

• Discovery and Development of Anti-TNF Therapy: Pillar of a Therapeutic Revolution. Pillar of a Therapeutic Revolution.

  Chapter

  Feldmann M., (2014), Molecular Biology of B Cells: Second Edition, 541 - 547

• Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitis

  Conference paper

  Wythe SE. et al, (2014), IMMUNOLOGY, 143, 162 - 162

• Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

  Journal article

  McCann FE. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 2728 - 2738

• Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  Journal article

  Nielsen N. et al, (2014), Immunology, 142, 581 - 593

• Reply: To PMID 23784528.

  Journal article

  Schmidt EM. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 1962 - 1963

• TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

  Journal article

  Ruspi G. et al, (2014), Cellular signalling, 26, 683 - 690

• OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

  Journal article

  Gwyer Findlay E. et al, (2014), Proceedings of the National Academy of Sciences of the United States of America, 111, 2289 - 2294

• A conversation with Marc Feldmann. Interviewed by Ushma S. Neill.

  Journal article

  Feldmann M., (2014), The Journal of clinical investigation, 124, 1 - 2

• Anti-tnf therapy: 20 years from our first therapeutic adventure

  Chapter

  Nanchahal J. et al, (2014), Cytokine Frontiers: Regulation of Immune Responses in Health and Disease, 215 - 244

• Design and optimisation of bioactive cyclic peptides: generation of a down-regulator of TNF secretion.

  Journal article

  New R. et al, (2014), Molecules (Basel, Switzerland), 19, 21529 - 21540

• Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

  Journal article

  Schmidt EM. et al, (2013), Arthritis and rheumatism, 65, 2262 - 2273

• Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

  Journal article

  Verjee LS. et al, (2013), Proceedings of the National Academy of Sciences of the United States of America, 110, E928 - E937

• RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.

  Journal article

  Gasparini C. et al, (2013), Cytokine, 61, 736 - 740

• TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes.

  Journal article

  Brenner C. et al, (2012), Scandinavian journal of immunology, 76, 359 - 370

• Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA.

  Journal article

  Larsen H. et al, (2012), Arthritis research & therapy, 14

• Alarmins: awaiting a clinical response.

  Journal article

  Chan JK. et al, (2012), The Journal of clinical investigation, 122, 2711 - 2719

• Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis.

  Journal article

  Raatz Y. et al, (2012), Arthritis research & therapy, 14

• Effective targeting of the tumor microenvironment for cancer therapy.

  Journal article

  Jiang P. et al, (2012), Anticancer research, 32, 1203 - 1212

• NF-κB as a target for modulating inflammatory responses.

  Journal article

  Gasparini C. and Feldmann M., (2012), Current pharmaceutical design, 18, 5735 - 5745

• The TNF/TNF-R family: A gold mine for clinical therapeutic targets?

  Journal article

  Feldmann M., (2011), Advances in Experimental Medicine and Biology, 691, ix - x

• Resolving postoperative neuroinflammation and cognitive decline.

  Journal article

  Terrando N. et al, (2011), Annals of neurology, 70, 986 - 995

• Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

  Journal article

  Beavis PA. et al, (2011), Proceedings of the National Academy of Sciences of the United States of America, 108, 16717 - 16722

• Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.

  Journal article

  Andersson AK. et al, (2011), Arthritis and rheumatism, 63, 2617 - 2629

• IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

  Journal article

  McNamee KE. et al, (2011), Pain, 152, 1838 - 1845

• IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

  Journal article

  Krausgruber T. et al, (2011), Nature immunology, 12, 231 - 238

• Unexpected protective role for Toll-like receptor 3 in the arterial wall.

  Journal article

  Cole JE. et al, (2011), Proceedings of the National Academy of Sciences of the United States of America, 108, 2372 - 2377

• TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.

  Journal article

  Glass GE. et al, (2011), Proceedings of the National Academy of Sciences of the United States of America, 108, 1585 - 1590

• Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade.

  Journal article

  Gompels LL. et al, (2011), Arthritis research & therapy, 13

• Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.

  Journal article

  Turner JJ. et al, (2010), Clinical and experimental immunology, 162, 487 - 493

• Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

  Journal article

  Terrando N. et al, (2010), Proceedings of the National Academy of Sciences of the United States of America, 107, 20518 - 20522

• Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis.

  Journal article

  Malik NM. et al, (2010), Rheumatology (Oxford, England), 49, 1828 - 1839

• Role of interleukin-1beta in postoperative cognitive dysfunction.

  Journal article

  Cibelli M. et al, (2010), Annals of neurology, 68, 360 - 368

• Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

  Journal article

  Page TH. et al, (2010), Journal of immunology (Baltimore, Md. : 1950), 185, 3694 - 3701

• IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.

  Journal article

  Smallie T. et al, (2010), The Journal of experimental medicine, 207, 2081 - 2088

• SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

  Journal article

  Drexler SK. et al, (2010), Arthritis and rheumatism, 62, 2249 - 2261

• The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.

  Journal article

  Weng L. et al, (2010), Annals of the rheumatic diseases, 69, 1519 - 1526

• Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

  Journal article

  Feldmann M. and Maini RN., (2010), Journal of immunology (Baltimore, Md. : 1950), 185, 791 - 794

• Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

  Journal article

  Drexler SK. et al, (2010), Scandinavian journal of immunology, 71, 393 - 402

• Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.

  Journal article

  McNamee KE. et al, (2010), Pain, 149, 386 - 392

• Directed issue: novel concepts in inflammation.

  Journal article

  Gilroy DW. et al, (2010), The international journal of biochemistry & cell biology, 42, 480 - 481

• Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis.

  Journal article

  Dobson R. et al, (2010), Journal of neuroimmunology, 220, 99 - 103

• Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

  Journal article

  McCann FE. et al, (2010), Arthritis research & therapy, 12

• What have we learnt from targeted anti-TNF therapy?

  Journal article

  Feldmann M. et al, (2010), Annals of the rheumatic diseases, 69 Suppl 1, i97 - i99

• Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.

  Journal article

  Wegner N. et al, (2010), Immunological reviews, 233, 34 - 54

• The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.

  Journal article

  Terrando N. et al, (2010), Critical care (London, England), 14

• Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

  Journal article

  Hillyer P. et al, (2009), Rheumatology (Oxford, England), 48, 1581 - 1589

• Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.

  Journal article

  Monaco C. et al, (2009), Circulation, 120, 2462 - 2469

• TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

  Journal article

  Kuai J. et al, (2009), Rheumatology (Oxford, England), 48, 1352 - 1358

• Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.

  Journal article

  Taylor PC. and Feldmann M., (2009), Nature reviews. Rheumatology, 5, 578 - 582

• A view from a European medical academic who spends time in the US.

  Journal article

  Feldmann M., (2009), The Journal of clinical investigation, 119, 2861 - 2862

• RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

  Journal article

  Gasparini C. et al, (2009), European journal of immunology, 39, 2215 - 2223

• Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

  Journal article

  Sumariwalla PF. et al, (2009), Rheumatology (Oxford, England), 48, 32 - 38

• Translating molecular insights in autoimmunity into effective therapy.

  Journal article

  Feldmann M., (2009), Annual review of immunology, 27, 1 - 27

• In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.

  Journal article

  Brennan F. and Feldmann M., (2009), Arthritis research & therapy, 11

• Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

  Journal article

  Sacre SM. et al, (2008), Journal of immunology (Baltimore, Md. : 1950), 181, 8002 - 8009

• Many cytokines are very useful therapeutic targets in disease.

  Journal article

  Feldmann M., (2008), The Journal of clinical investigation, 118, 3533 - 3536

• Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

  Journal article

  Raichel L. et al, (2008), European journal of immunology, 38, 2905 - 2915

• Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

  Journal article

  Inglis JJ. et al, (2008), Arthritis and rheumatism, 58, 3110 - 3119

• Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.

  Journal article

  Sumariwalla PF. et al, (2008), Arthritis and rheumatism, 58, 3071 - 3080

• Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.

  Journal article

  Andersson AK. et al, (2008), Scandinavian journal of immunology, 68, 103 - 111

• Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.

  Journal article

  Feldmann M. and Maini SR., (2008), Immunological reviews, 223, 7 - 19

• Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

  Journal article

  Williams LM. et al, (2008), Molecular immunology, 45, 2446 - 2454

• CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.

  Journal article

  Simelyte E. et al, (2008), Arthritis and rheumatism, 58, 1038 - 1043

• Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.

  Journal article

  Brennan FM. et al, (2008), Arthritis research & therapy, 10

• Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

  Journal article

  Jin P. et al, (2008), Arthritis research & therapy, 10

• Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

  Journal article

  Wales J. et al, (2007), Biochemical Society transactions, 35, 1501 - 1503

• Targeting intracellular signaling: a novel approach to vaccination.

  Journal article

  Wales J. et al, (2007), Expert review of vaccines, 6, 971 - 980

• Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.

  Journal article

  Inglis JJ. et al, (2007), Arthritis and rheumatism, 56, 4015 - 4023

• Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

  Journal article

  Sacre SM. et al, (2007), Annals of the rheumatic diseases, 66 Suppl 3, iii81 - iii86

• Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

  Journal article

  Lundberg AM. et al, (2007), Blood, 110, 3245 - 3252

• The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.

  Journal article

  Inglis JJ. et al, (2007), Rheumatology (Oxford, England), 46, 1428 - 1432

• Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.

  Journal article

  Williams RO. et al, (2007), Current opinion in pharmacology, 7, 412 - 417

• Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.

  Journal article

  Sheryanna A. et al, (2007), Journal of the American Society of Nephrology : JASN, 18, 1167 - 1179

• Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

  Journal article

  Bondeson J. et al, (2007), The Journal of rheumatology, 34, 523 - 533

• A new JCI conflict-of-interest policy.

  Journal article

  Neill US. et al, (2007), The Journal of clinical investigation, 117, 506 - 508

• Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.

  Journal article

  Sacre SM. et al, (2007), Journal of immunology (Baltimore, Md. : 1950), 178, 2148 - 2154

• The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.

  Journal article

  Sacre SM. et al, (2007), The American journal of pathology, 170, 518 - 525

• The pitfalls in the development of biologic therapy.

  Journal article

  Maini RN. and Feldmann M., (2007), Nature clinical practice. Rheumatology, 3

• Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.

  Journal article

  Edwards CJ. et al, (2007), Molecular Medicine, 13, 40 - 58

• Crystal-ball gazing--the future of immunological research viewed from the cutting edge.

  Journal article

  Brent L. et al, (2007), Clinical and experimental immunology, 147, 1 - 10

• Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.

  Journal article

  Tyndall A. et al, (2007), Arthritis research & therapy, 9

• Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.

  Journal article

  Inglis JJ. et al, (2007), Arthritis research & therapy, 9

• Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

  Journal article

  Amos N. et al, (2006), Rheumatology (Oxford, England), 45, 1201 - 1209

• Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.

  Journal article

  Andreakos E. et al, (2006), Proceedings of the National Academy of Sciences of the United States of America, 103, 14459 - 14464

• Cytokines as therapeutics and targets of therapeutics

  Journal article

  Vilček J. and Feldmann M., (2006), Rheumatologia, 20, 65 - 74

• Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.

  Journal article

  Feldmann M. and Pusey CD., (2006), Journal of the American Society of Nephrology : JASN, 17, 1243 - 1252

• Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.

  Journal article

  Grosjean J. et al, (2006), Biochemical and biophysical research communications, 340, 984 - 994

• The importance of T cell interactions with macrophages in rheumatoid cytokine production.

  Journal article

  Brennan FM. et al, (2006), Current topics in microbiology and immunology, 305, 177 - 194

• Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

  Journal article

  Waterston AM. et al, (2005), Cancer immunology, immunotherapy : CII, 54, 848 - 857

• Molecular therapeutic targets in rheumatoid arthritis.

  Journal article

  Sacre SM. et al, (2005), Expert reviews in molecular medicine, 7, 1 - 20

• Design of effective immunotherapy for human autoimmunity.

  Journal article

  Feldmann M. and Steinman L., (2005), Nature, 435, 612 - 619

• Anti-TNF therapy: where have we got to in 2005?

  Journal article

  Feldmann M. et al, (2005), Journal of autoimmunity, 25 Suppl, 26 - 28

• Cannabinoids in Models of Chronic Inflammatory Conditions

  Journal article

  Mechoulam R. et al, (2005), Phytochemistry Reviews, 4, 11 - 18

• The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.

  Journal article

  Andreakos E. et al, (2005), Frontiers in bioscience : a journal and virtual library, 10, 2478 - 2488

• Rheumatoid arthritis: pathogenic mechanisms and therapeutic targets

  Journal article

  Taylor PC. and Feldmann M., (2004), Drug Discovery Today: Disease Mechanisms, 1, 289 - 295

• Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.

  Journal article

  Taylor PC. et al, (2004), Current opinion in biotechnology, 15, 557 - 563

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

  Journal article

  Burstein S. and Zurier RB., (2004), Arthritis and rheumatism, 50, 4078 - 4079

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al - Reply

  Journal article

  Sumariwalla PF. et al, (2004), ARTHRITIS AND RHEUMATISM, 50, 4079 - 4080

• Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?

  Journal article

  Andreakos E. et al, (2004), Immunological reviews, 202, 250 - 265

• Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.

  Journal article

  Cope AP. and Feldmann M., (2004), Current opinion in immunology, 16, 780 - 786

• A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.

  Journal article

  Campbell J. et al, (2004), Journal of immunology (Baltimore, Md. : 1950), 173, 6928 - 6937

• Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages.

  Journal article

  Pertyńska-Marczewska M. et al, (2004), Cytokine, 28, 35 - 47

• New approaches to therapeutic immunomodulation for immune-mediated inflammatory disorders.

  Journal article

  Taylor PC. and Feldmann M., (2004), Current opinion in pharmacology, 4, 368 - 371

• Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.

  Journal article

  Monaco C. et al, (2004), Proceedings of the National Academy of Sciences of the United States of America, 101, 5634 - 5639

• P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.

  Journal article

  Sumariwalla PF. et al, (2004), Clinical and experimental immunology, 136, 67 - 75

• Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.

  Journal article

  Zhang Y. et al, (2004), The Journal of pharmacology and experimental therapeutics, 309, 348 - 355

• Historical review: Cytokines as therapeutics and targets of therapeutics.

  Journal article

  Vilcek J. and Feldmann M., (2004), Trends in pharmacological sciences, 25, 201 - 209

• TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.

  Journal article

  Waterston AM. et al, (2004), British journal of cancer, 90, 1279 - 1284

• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

  Journal article

  Sumariwalla PF. et al, (2004), Arthritis and rheumatism, 50, 985 - 998

• Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

  Journal article

  Andreakos E. et al, (2004), Blood, 103, 2229 - 2237

• T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.

  Journal article

  Monaco C. et al, (2004), Current drug targets. Inflammation and allergy, 3, 35 - 42

• The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.

  Journal article

  Feldmann M. et al, (2004), Best practice & research. Clinical rheumatology, 18, 59 - 80

• Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

  Journal article

  Feldmann M. et al, (2004), Novartis Foundation symposium, 256, 53 - 269

• Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

  Journal article

  Sacre SM. et al, (2004), Journal of endotoxin research, 10, 445 - 452

• Advanced glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells

  Journal article

  Pertńaska-Marczewska M. et al, (2003), Diabetologia Polska, 10, 375 - 380

• Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.

  Journal article

  Foxwell B. et al, (2003), Annals of the rheumatic diseases, 62 Suppl 2, ii90 - ii93

• Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis.

  Journal article

  Afuwape AO. et al, (2003), Gene therapy, 10, 1950 - 1960

• TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

  Journal article

  Feldmann M. and Maini RN., (2003), Nature Medicine, 9, 1245 - 1250

• Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.

  Journal article

  Feldmann M. and Maini RN., (2003), Nature medicine, 9, 1245 - 1250

• Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.

  Journal article

  Yoshimura S. et al, (2003), Scandinavian journal of immunology, 58, 165 - 172

• Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.

  Journal article

  Scheinin T. et al, (2003), Clinical and experimental immunology, 133, 38 - 43

• Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.

  Journal article

  Andreakos E. et al, (2003), Arthritis and rheumatism, 48, 1901 - 1912

• Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response.

  Journal article

  Mauri C. et al, (2003), Arthritis and rheumatism, 48, 839 - 845

• Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.

  Journal article

  Calder VL. et al, (2003), Scandinavian journal of immunology, 57, 261 - 270

• Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.

  Journal article

  Andreakos E. et al, (2003), Blood, 101, 983 - 991

• VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.

  Journal article

  Kiriakidis S. et al, (2003), Journal of cell science, 116, 665 - 674

• The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.

  Journal article

  Sumariwalla PF. et al, (2003), Arthritis research & therapy, 5, R32 - R39

• Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.

  Journal article

  Foey AD. et al, (2003), Arthritis research & therapy, 5, R317 - R328

• Monoclonal antibodies in immune and inflammatory diseases.

  Journal article

  Andreakos E. et al, (2002), Current opinion in biotechnology, 13, 615 - 620

• Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

  Journal article

  Feldmann M. et al, (2002), Annals of the rheumatic diseases, 61 Suppl 2, ii13 - ii18

• Cytokines and anti-cytokine biologicals in autoimmunity: present and future.

  Journal article

  Andreakos ET. et al, (2002), Cytokine & growth factor reviews, 13, 299 - 313

• TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.

  Journal article

  Ciesielski CJ. et al, (2002), European journal of immunology, 32, 2037 - 2045

• Development of anti-TNF therapy for rheumatoid arthritis.

  Journal article

  Feldmann M., (2002), Nature reviews. Immunology, 2, 364 - 371

• T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.

  Journal article

  Monaco C. et al, (2002), Journal of leukocyte biology, 71, 659 - 668

• Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.

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• How does infliximab work in rheumatoid arthritis?

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• NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.

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• Immunotherapy - Editorial overview

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• Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.

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• Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.

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• Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.

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• Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.

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• Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.

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• The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy.

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• Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system.

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• Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.

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• The role of TNF alpha and IL-1 in rheumatoid arthritis.

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• Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.

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• Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.

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• Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.

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• Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.

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• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

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• A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.

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• Gene therapy for chronic relapsing experimental allergic encephalomyelitis using cells expressing a novel soluble p75 dimeric TNF receptor.

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• The role of cytokines in the pathogenesis of rheumatoid arthritis.

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• Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool.

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• Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.

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• The murine p75 TNF receptor promoter region: DNA sequence and characterization of a cis-acting silencer.

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• Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.

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• IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.

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• Similarities in the mechanisms of action of pulse corticosteroids and anti-tumor necrosis factor alpha therapy in rheumatoid arthritis - Reply

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• Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.

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• Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

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• DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.

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• Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2.

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• Longitudinal study of soluble adhesion molecules in multiple sclerosis: correlation with gadolinium enhanced magnetic resonance imaging.

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• Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.

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• Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis.

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• Humoral and cellular responses raised against the human HER2 oncoprotein are cross-reactive with the homologous product of the new proto-oncogene, but do not protect rats against B104 tumors expressing mutated neu.

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• Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.

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• Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action.

  Journal article

  Feldmann M. et al, (1995), Journal of inflammation, 47, 90 - 96

• Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.

  Journal article

  Brennan FM. et al, (1995), Chemical immunology, 60, 48 - 60

• TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.

  Journal article

  Butler DM. et al, (1994), Cytokine, 6, 616 - 623

• IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.

  Journal article

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• Targeting TNF alpha for the therapy of rheumatoid arthritis.

  Journal article

  Maini RN. et al, (1994), Clinical and experimental rheumatology, 12 Suppl 11, S63 - S66

• Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes.

  Journal article

  Joyce DA. et al, (1994), European journal of immunology, 24, 2699 - 2705

• Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells.

  Journal article

  Paleolog EM. et al, (1994), Blood, 84, 2578 - 2590

• Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis.

  Journal article

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• Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.

  Journal article

  Elliott MJ. et al, (1994), Lancet (London, England), 344, 1105 - 1110

• Use of anti-tumor necrosis factor antibodies in rheumatoid arthritis.

  Journal article

  Feldmann M. et al, (1994), Journal of interferon research, 14, 299 - 300

• Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins.

  Journal article

  Baker D. et al, (1994), European journal of immunology, 24, 2040 - 2048

• p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.

  Journal article

  Butler DM. et al, (1994), European cytokine network, 5, 441 - 448

• Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.

  Journal article

  Corcoran AE. et al, (1994), European journal of biochemistry, 223, 831 - 840

• Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.

  Journal article

  Gibbons DL. et al, (1994), European journal of immunology, 24, 1879 - 1885

• Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.

  Journal article

  Cope AP. et al, (1994), The Journal of clinical investigation, 94, 749 - 760

• TNF alpha as a therapeutic target in rheumatoid arthritis.

  Journal article

  Feldmann M. et al, (1994), Circulatory shock, 43, 179 - 184

• Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells.

  Journal article

  Mullins RJ. et al, (1994), Journal of immunology (Baltimore, Md. : 1950), 152, 5572 - 5580

• Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

  Journal article

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• Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.

  Journal article

  Williams RO. et al, (1994), Proceedings of the National Academy of Sciences of the United States of America, 91, 2762 - 2766

• From the laboratory to the clinic: Evaluation of cytokines in rheumatoid arthritis highlights TNF-alpha as a new therapeutic target

  Journal article

  Feldmann M. et al, (1994), Immunologist, 2, 172 - 176

• Erratum: c-erbB-2 Oncoprotein in screen-detected breast carcinoma: An immunohistological study (International Journal of Cancer (1993) 55 (63-65))

  Journal article

  Soomro S. et al, (1994), International Journal of Cancer, 56

• Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.

  Journal article

  Maini RN. et al, (1994), Springer seminars in immunopathology, 16, 327 - 336

• Selective activation of blood T cells in children with newly diagnosed insulin dependent diabetes mellitus.

  Journal article

  Kontiainen S. et al, (1994), Autoimmunity, 19, 63 - 66

• Prospects for cytokines in human immunotherapy

  Chapter

  Haworth C. et al, (1994), The Cytokine Handbook, 461 - 487

• Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.

  Journal article

  Elliott MJ. et al, (1993), Arthritis and rheumatism, 36, 1681 - 1690

• Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.

  Journal article

  Kristensen M. et al, (1993), Clinical and experimental immunology, 94, 354 - 362

• Antilipid A monoclonal antibody HA-1A decreases the capacity of bacterial lipopolysaccharide to activate human vascular endothelial cells by an immune adherence mechanism.

  Journal article

  Paleolog EM. et al, (1993), Cytokine, 5, 570 - 577

• T cells involved in human autoimmune disease are resistant to tolerance induction.

  Journal article

  Dayan CM. et al, (1993), Journal of immunology (Baltimore, Md. : 1950), 151, 1606 - 1613

• c-erbB-2 oncoprotein in screen-detected breast carcinoma: an immunohistological study.

  Journal article

  Soomro S. et al, (1993), International journal of cancer, 55, 63 - 65

• Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus.

  Journal article

  Aderka D. et al, (1993), Arthritis and rheumatism, 36, 1111 - 1120

• Antilipid a monoclonal antibody HA-1A: immune complex clearance of endotoxin reduces TNF-alpha, IL-1 beta and IL-6 production.

  Journal article

  Katsikis P. et al, (1993), Cytokine, 5, 348 - 353

• Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. III: Cytokine studies.

  Journal article

  Haworth C. et al, (1993), British journal of cancer, 67, 1346 - 1350

• Increased limb involvement in murine collagen-induced arthritis following treatment with anti-interferon-gamma.

  Journal article

  Williams RO. et al, (1993), Clinical and experimental immunology, 92, 323 - 327

• Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.

  Journal article

  Cope AP. et al, (1993), Cytokine, 5, 205 - 212

• TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.

  Journal article

  Maini RN. et al, (1993), Clinical and experimental rheumatology, 11 Suppl 8, S173 - S175

• The effects of tumor necrosis factor (TNF) derivatives on TNF receptors.

  Journal article

  Tchorzewski H. et al, (1993), Cytokine, 5, 125 - 132

• The effect of tumour necrosis factor-alpha (TNF-alpha) muteins on human neutrophils in vitro.

  Journal article

  Tchorzewski H. et al, (1993), Mediators of inflammation, 2, 41 - 48

• Cytokines in autoimmunity.

  Journal article

  Brennan FM. and Feldmann M., (1992), Current opinion in immunology, 4, 754 - 759

• Detection of cytokines at the site of tuberculin-induced delayed-type hypersensitivity in man.

  Journal article

  Chu CQ. et al, (1992), Clinical and experimental immunology, 90, 522 - 529

• Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis.

  Journal article

  Deleuran BW. et al, (1992), British journal of rheumatology, 31, 801 - 809

• Cytokine receptors: structure and signal transduction.

  Journal article

  Foxwell BM. et al, (1992), Clinical and experimental immunology, 90, 161 - 169

• Contrasting effects of interferon gamma and interleukin 4 on responses of human vascular endothelial cells to tumour necrosis factor alpha.

  Journal article

  Paleolog EM. et al, (1992), Cytokine, 4, 470 - 478

• Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

  Journal article

  Williams RO. et al, (1992), Proceedings of the National Academy of Sciences of the United States of America, 89, 9784 - 9788

• Distribution of interleukin 1 receptor antagonist protein (IRAP), interleukin 1 receptor, and interleukin 1 alpha in normal and psoriatic skin. Decreased expression of IRAP in psoriatic lesional epidermis.

  Journal article

  Kristensen M. et al, (1992), The British journal of dermatology, 127, 305 - 311

• Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha.

  Journal article

  Deleuran BW. et al, (1992), Arthritis and rheumatism, 35, 1170 - 1178

• Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair.

  Journal article

  Chu CQ. et al, (1992), British journal of rheumatology, 31, 653 - 661

• Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.

  Journal article

  Cope AP. et al, (1992), Arthritis and rheumatism, 35, 1160 - 1169

• HER2 (c-erbB-2) oncoprotein expression in colorectal adenocarcinoma: an immunohistological study using three different antibodies.

  Journal article

  Arnaout AH. et al, (1992), Journal of clinical pathology, 45, 726 - 727

• Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-gamma) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes.

  Journal article

  Sadeghi R. et al, (1992), Cytokine, 4, 287 - 297

• Upregulation of HLA class II, but not intercellular adhesion molecule 1 (ICAM-1) by granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-3 (IL-3) in synergy with dexamethasone.

  Journal article

  Sadeghi R. et al, (1992), European cytokine network, 3, 373 - 380

• Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.

  Journal article

  Brennan FM. et al, (1992), European journal of immunology, 22, 1907 - 1912

• TNF alpha--a pivotal role in rheumatoid arthritis?

  Journal article

  Brennan FM. et al, (1992), British journal of rheumatology, 31, 293 - 298

• T cell activation and antigen presentation in human thyroid autoimmunity.

  Journal article

  Feldmann M. et al, (1992), Journal of autoimmunity, 5 Suppl A, 115 - 121

• T-cell-targeted immunotherapy.

  Journal article

  Feldmann M. et al, (1992), Immunology today, 13, 84 - 85

• Detection of in vivo production of tumour necrosis factor-alpha by human thyroid epithelial cells.

  Journal article

  Zheng RQ. et al, (1992), Immunology, 75, 456 - 462

• Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.

  Journal article

  Shalaby MR. et al, (1992), The Journal of experimental medicine, 175, 217 - 225

• Mechanism of Graves thyroiditis: implications for concepts and therapy of autoimmunity.

  Journal article

  Feldmann M. et al, (1992), International reviews of immunology, 9, 91 - 106

• Autoimmune thyroiditis and targeted anti-T cell immunotherapy in man.

  Journal article

  Dayan CM. et al, (1992), Autoimmunity, 11, 189 - 198

• Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.

  Journal article

  Feldmann M. et al, (1992), Progress in growth factor research, 4, 247 - 255

• Regulatory interactions among autologous T cell clones. Human bifunctional T cell clones regulate the activity of an autologous T cell clone.

  Journal article

  Naor D. et al, (1991), Annals of the New York Academy of Sciences, 636, 135 - 146

• Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.

  Journal article

  Chu CQ. et al, (1991), Clinical and experimental immunology, 86, 380 - 386

• Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.

  Journal article

  Hawrylowicz CM. et al, (1991), The Journal of experimental medicine, 174, 785 - 790

• Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.

  Journal article

  Haworth C. et al, (1991), European journal of immunology, 21, 2575 - 2579

• Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis.

  Journal article

  Chu CQ. et al, (1991), Arthritis and rheumatism, 34, 1125 - 1132

• Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.

  Journal article

  Dayan CM. et al, (1991), Proceedings of the National Academy of Sciences of the United States of America, 88, 7415 - 7419

• Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta.

  Journal article

  Turner M. et al, (1991), European journal of immunology, 21, 1635 - 1639

• Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor.

  Journal article

  Barrett K. et al, (1991), European journal of immunology, 21, 1649 - 1656

• Production of interleukin-1 and interleukin-6 by human keratinocytes and squamous cell carcinoma cell lines.

  Journal article

  Partridge M. et al, (1991), The Journal of investigative dermatology, 96, 771 - 776

• Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage.

  Journal article

  Kontiainen S. et al, (1991), Clinical and experimental immunology, 83, 347 - 351

• c-erbB-2 expression in different histological types of invasive breast carcinoma.

  Journal article

  Soomro S. et al, (1991), Journal of clinical pathology, 44, 211 - 214

• Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods.

  Journal article

  Zheng RQ. et al, (1991), Clinical and experimental immunology, 83, 314 - 319

• Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.

  Journal article

  Feldmann M. et al, (1991), Immunological reviews, 119, 105 - 123

• Interleukin 4 induces interleukin 6 production by endothelial cells: synergy with interferon-gamma.

  Journal article

  Howells G. et al, (1991), European journal of immunology, 21, 97 - 101

• Cytokine networks: do we understand them well enough to facilitate clinical benefits?

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  Feldmann M., (1991), European cytokine network, 2, 5 - 9

• Cytokine expression in rheumatoid arthritis.

  Journal article

  Brennan FM. et al, (1991), British journal of rheumatology, 30 Suppl 1, 76 - 80

• Interleukin-6 localisation in the synovial membrane in rheumatoid arthritis.

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  Field M. et al, (1991), Rheumatology international, 11, 45 - 50

• Human islet cell induced T cell lines and clones from diabetic children.

  Journal article

  Kontiainen S. et al, (1991), Autoimmunity, 8, 193 - 197

• Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells in Graves' and Hashimoto's diseases.

  Journal article

  Zheng RQ. et al, (1990), Journal of autoimmunity, 3, 727 - 736

• CD4+ T-cell clones from autoimmune thyroid tissue cannot be classified according to their lymphokine production.

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  Grubeck-Loebenstein B. et al, (1990), Scandinavian journal of immunology, 32, 433 - 440

• Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

  Journal article

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• Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.

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• Review of UK data on the rheumatic diseases--2. Rheumatoid arthritis.

  Journal article

  Hazes JM. and Silman AJ., (1990), British journal of rheumatology, 29, 310 - 312

• Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures.

  Journal article

  Brennan FM. et al, (1990), Clinical and experimental immunology, 81, 278 - 285

• Specific interactions between a human CD4+ clone and autologous CD4+ bifunctional immunoregulatory clones.

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  Naor D. et al, (1990), Immunological reviews, 116, 63 - 83

• Interactions between autologous T cell clones.

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  Naor D. et al, (1990), Cellular immunology, 128, 490 - 502

• CD5+B cells in rheumatoid arthritis and Sjögren's syndrome.

  Journal article

  Maini RN. et al, (1990), Clinical and experimental rheumatology, 8 Suppl 5, 67 - 68

• Cytokine production in the rheumatoid joint: implications for treatment.

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  Feldmann M. et al, (1990), Annals of the rheumatic diseases, 49 Suppl 1, 480 - 486

• Transforming growth factor beta induces the production of interleukin 6 by human peripheral blood mononuclear cells.

  Journal article

  Turner M. et al, (1990), Cytokine, 2, 211 - 216

• Cells with dendritic morphology and bright interleukin-1 alpha staining circulate in the blood of patients with rheumatoid arthritis.

  Journal article

  Barkley DE. et al, (1990), Clinical and experimental immunology, 80, 25 - 31

• Interleukin 7 is a growth factor for mature human T cells.

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• Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes.

  Journal article

  Chantry D. et al, (1990), Cytokine, 2, 60 - 67

• Epidermal growth factor and transforming growth factor-alpha suppress HLA class II induction in human thyroid epithelial cells.

  Journal article

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• Interleukin 7 and interleukin 4 stimulate human thymocyte growth through distinct mechanisms.

  Journal article

  Varma C. et al, (1990), Cytokine, 2, 55 - 59

• STIMULATION OF HUMAN AND MURINE THYMOCYTE PROLIFERATION BY INTERLEUKIN-7

  Conference paper

  CHANTRY D. et al, (1990), MOLECULAR AND CELLULAR BIOLOGY OF CYTOKINES, 10, 535 - 540

• MODULATION OF CYTOKINE PRODUCTION AND FUNCTION BY TRANSFORMING GROWTH-FACTOR-BETA

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  TURNER M. et al, (1990), MOLECULAR AND CELLULAR BIOLOGY OF CYTOKINES, 10, 477 - 482

• Regulation of expression of human IL-1 alpha and IL-1 beta genes.

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• Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4.

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  Londei M. et al, (1989), Proceedings of the National Academy of Sciences of the United States of America, 86, 8502 - 8506

• Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation.

  Journal article

  Partridge M. et al, (1989), British journal of cancer, 60, 542 - 548

• Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6.

  Journal article

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• Increased expression of HLA-DQ antigens by interstitial cells and endothelium in the synovial membrane of rheumatoid arthritis patients compared with reactive arthritis patients.

  Journal article

  Barkley D. et al, (1989), Arthritis and rheumatism, 32, 955 - 963

• Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome.

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• Human T cell clones present antigen.

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• Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.

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• Modulation of cytokine production by transforming growth factor-beta.

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• The detection by immunofluorescence of distinct cell populations producing interleukin-1 alpha and interleukin-1 beta in activated human peripheral blood.

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• Intrathyroidal cytokine production in thyroid disease.

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• T-cell clone anti-clone interactions. Effects on suppressor and helper activities.

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• Cytokine production in culture by cells isolated from the synovial membrane.

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• 'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.

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• Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta.

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• T cells and lymphokines.

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• Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter.

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• MS: a localized immune disease of the central nervous system.

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• CD4+ T-cell damage to islet beta cells.

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• Effect of cytokines on HLA-DR and IL-1 production by a monocytic tumour, THP-1.

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• Analysis of T-cell receptor usage in activated T-cell clones from Hashimoto's thyroiditis and Graves' disease.

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• AUTOREACTIVITY AGAINST CLASS-I OR CLASS-II ANTIGENS - IMMUNOLOGICAL DOWN-REGULATION MECHANISM

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• High rate of HLA class II mRNA synthesis in rheumatoid arthritis joints and its persistence in culture: down-regulation by recombinant interleukin 2.

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• Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha.

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• Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis.

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• Comparative and combined effects of transforming growth factors alpha and beta, interleukin-1 and interferon-gamma on rheumatoid synovial cell proliferation, glycolysis and prostaglandin E production.

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• Molecular mechanisms involved in human autoimmune diseases: relevance of chronic antigen presentation. Class II expression and cytokine production.

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• The role of cytokines in autoimmunity.

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  Chantry D. and Feldmann M., (1989), Biotechnology therapeutics, 1, 361 - 409

• Tumour necrosis factor synergises with gamma interferon on the induction of mRNA for DR alpha chain on thyrocytes from Graves' disease and non toxic goitre.

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• Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.

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• Do CD4-positive cytotoxic T cells damage islet beta cells in type 1 diabetes?

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• Post-transcriptional control of IL-1 gene expression in the acute monocytic leukemia line THP-1.

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• Interleukin 1 (IL-1) and tumour necrosis factor synergise in the induction of IL-1 synthesis by human vascular endothelial cells.

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• Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.

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• Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis.

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• T cells expressing gamma delta chain receptors in rheumatoid arthritis.

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• The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+.

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• Regulation of clonal growth by anti-T-cell receptor antibody-directed lysis.

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• Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

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  Essery G. et al, (1988), Immunology, 64, 413 - 417

• Comparison of patterns of expression of tumour necrosis factor, lymphotoxin and interleukin-6 mRNA.

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  Turner M. and Feldmann M., (1988), Biochemical and biophysical research communications, 153, 1144 - 1151

• Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.

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  Grubeck-Loebenstein B. et al, (1988), The Journal of clinical investigation, 81, 1608 - 1614

• T-cell activation in health and disease.

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  Feldmann M., (1988), Immunology today, 9, 121 - 124

• Understanding what infiltrating cells do in autoimmunity: combination of cellular and molecular approaches.

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  Feldmann M. et al, (1988), Transplantation proceedings, 20, 311 - 314

• Effect of recombinant cytokines on glycolysis and fructose 2,6-bisphosphate in rheumatoid synovial cells in vitro.

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  Taylor DJ. et al, (1988), The Biochemical journal, 250, 111 - 115

• Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

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• Efficient propagation and cloning of human T cells in the absence of antigen by means of OKT3, interleukin 2, and antigen-presenting cells.

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  Londei M. et al, (1988), Scandinavian journal of immunology, 27, 35 - 46

• Regulation of HLA class II expression and the pathogenesis of autoimmunity.

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  Feldmann M. et al, (1988), Concepts in immunopathology, 5, 44 - 56

• Role of HLA class II and cytokine expression in rheumatoid arthritis.

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  Feldmann M. et al, (1988), Scandinavian journal of rheumatology. Supplement, 76, 39 - 46

• Analysis of T cell clones in rheumatoid arthritis.

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  Feldmann M. et al, (1988), Springer seminars in immunopathology, 10, 157 - 167

• Analysis of endocrine autoimmunity by cloning human T lymphocytes from target tissues

  Journal article

  Feldmann M. and Londei M., (1987), Bailliere's Clinical Immunology and Allergy, 1, 101 - 108

• Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.

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• Human T cells from autoimmune and normal individuals can produce tumor necrosis factor.

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• Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways.

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• A phenotypically dominant regulatory mechanism suppresses major histocompatibility complex class II gene expression in a murine plasmacytoma.

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• HLA-D subregion expression by thyroid epithelium in autoimmune thyroid diseases and induced in vitro.

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• Enhancement of thyrocyte HLA class II expression by thyroid stimulating hormone.

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• B-CELL STIMULATORY FACTOR-II (BSF2/IL-6) AND RHEUMATOID-ARTHRITIS

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• HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin.

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• Association of phosphorylation of the T3 antigen with immune activation of T lymphocytes.

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• Regulation of HLA class II expression and its role in autoimmune disease.

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• Interferons and autoimmunity.

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• New ideas in thyroid autoimmunity.

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• Comparison of the cellular infiltrate of Hashimoto's thyroiditis in vivo and after in vitro cell growth.

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• Autoimmune disorders--analysis by study of T cells, implications and speculations.

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• Derivation of ganglioside-specific T cell lines of suppressor or helper phenotype from cerebrospinal fluid of multiple sclerosis patients.

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• Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas.

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• Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth.

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• The cellular pathway of antigen presentation: biochemical and functional analysis of antigen processing in dendritic cells and macrophages.

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• Autoimmune disease: synergy of HLA class II overexpression and abrogation of self tolerance.

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• CELLS THAT SUPPRESS IMMUNITY

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• Regulation of macrophage accessory cell activity by mycobacteria. II. In vitro inhibition of Ia expression by Mycobacterium microti.

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• Regulation of macrophage accessory cell activity by mycobacteria. I. Ia expression in normal and irradiated mice infected with Mycobacterium microti.

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• Inappropriate major histocompatibility complex class II expression by thyroid follicular cells in thyroid autoimmune disease and by pancreatic beta cells in type I diabetes.

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• Human T cell clones, tolerance, and the analysis of autoimmunity.

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• AUTOANTIGEN PRESENTATION BY TARGET-CELLS - ITS POSSIBLE ROLE IN DETERMINING AUTOANTIBODY SPECIFICITY

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• Nonphagocytic dendritic cells are effective accessory cells for anti-mycobacterial responses in vitro.

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• Tolerance in T-cell clones.

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• Functional expression of HLA-DP genes transfected into mouse fibroblasts.

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• Lymphokines and interleukins emerge from the primeval soup.

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• Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines.

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• Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells.

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• The relationship between secreted and cell surface antigen-binding molecules synthesized by T cells. I. Function-related isotypic determinants on T cells defined by antisera to antigen-specific helper and suppressor factors.

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• Mechanism of action of immune response genes.

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  Feldmann M., (1984), Annales d'immunologie, 135C, 402 - 407

• Clonal approaches to immune regulation by lymphocytes.

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• [A change in the expression of histocompatibility antigens could lead to autoimmunity]

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• Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction.

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  Lamb JR. and Feldmann M., (1984), Nature, 308, 72 - 74

• Inhibition of T cell proliferation by antibodies to synthetic peptides.

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• Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity.

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• The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.

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• Tolerance of T-cell clones is associated with membrane antigen changes.

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• Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

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• Antigen-specific and non-specific helper activities derived from supernatants of human influenza virus-specific T-cell lines.

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• A monoclonal antibody against antigen-specific helper factor augments T-cell help.

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• Induction of a T-cell mediated suppressor activity by soluble products from antigen-specific helper/inducer human T-cell lines.

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• A human suppressor T cell clone which recognizes an autologous helper T cell clone.

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  Lamb JR. and Fledmann M., (1982), Nature, 300, 456 - 458

• An influenza virus matrix protein-specific human T cell line with helper activity for in vitro anti-hemagglutinin antibody production.

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• Specific suppression of antibody responses in vivo. I. Effects of in vitro produced suppressor factor.

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• Genetically restricted and unrestricted antigen specific helper factors

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• Structure of antigen-specific suppressor factors: current views.

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• Ia and macrophages in alloproliferation and allocytotoxicity.

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• Definition of function-related isotypic markers on T cells.

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• A comparative study of accessory cells derived from the peritoneum and from solid tissues.

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• Long-term human T-helper lines producing specific helper factor reactive to influenza virus.

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• T-cell hybridomas producing hapten-specific suppressor factors.

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• Antigen-specific helper factor reacts with antibodies to human beta 2 microglobulin.

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• Genetics of human T cell-monocyte interaction in helper cell induction.

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• Nature of macrophage-T cell interaction in secondary helper cell generation in vitro. Genetic restriction of macrophage-T cell interaction, which determines T-B genetic restriction.

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• Induction of human antigen-specific suppressor factors in vitro.

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• Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.

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• Nature of T cell-macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host.

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• Antigen specific T cell factors.

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• Specific T helper and suppressor cells and factors induced in vitro to the hapten NP.

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• Antibody production to antigen-specific factors.

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• Structural characteristics of antigen-specific suppressor factors: definition of 'constant' region and 'variable' region determinants.

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  Kontiainen S. and Feldmann M., (1979), Thymus, 1, 59 - 79

• Selective production of human antigen specific helper factor from normal volunteers: implications for human Ir genes.

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• Induction of antibody responses in vivo by antigen specific helper factor.

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• Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).

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• Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?

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• Induction of human antigen-specific and non-specific helper factors in vitro.

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• Nature of T-cell macrophage interaction in helper-cell induction in vitro. II. Two stages of T-helper-cell differentiation analyzed in irradiation and allophenic chimeras.

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  Erb P. et al, (1979), The Journal of experimental medicine, 149, 686 - 701

• MLC and CMC reactivity and specificity of idiotype-specific lymphoid cells enriched for histocompatibility (H-2) antigens.

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• Human and mouse specific T-cell helper factors assayed in vivo and in vitro: implications for human Ir genes.

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• Suppressor cell induction in vitro. VI. Production of suppressor factors to synthetic polypeptides GAT and (T,G)-A--L from cells of responder and nonresponder mice.

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• Macrophage-lymphocyte interactions in immune induction.

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• Comparison of antigen-specific I-region-associated cell interaction factors.

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• Human T-cell responses in vitro: cell interactions and factors.

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• Cellular interactions in antibody production

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  Howie S. and Feldmann M., (1978), Clinics in Rheumatic Diseases, 4, 481 - 498

• Nature of T cell-macrophage interaction in helper cell induction in vitro. I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming.

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  Erb P. et al, (1978), European journal of immunology, 8, 786 - 792

• T-cell lines producing antigen-specific suppressor factor.

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• Immune response (Ir) genes expressed at macrophage-B lymphocyte interactions.

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• Cellular basis of the humoral immune response in mouse and hamster.

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• Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships.

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• COMPLEMENTATION OF H-2-LINKED IR GENES - USE OF HELPER FACTOR TO ANALYZE RESPONSES TO GLYPHE

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• T cell hybrids with T cell functions.

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• Complexity of cell interactions: analysis using antigens under Ir gene control.

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• Requirement for interactions between two subpopulations of T cells for helper cell induction in vitro.

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• In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.

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  Howie S. and Feldman M., (1977), European journal of immunology, 7, 417 - 421

• The role of macrophages in the generation of T helper cells. V. Evidence for differential activation of short-lived T1 and long-lived T2 lymphocytes by the macrophage factors GRF and NMF.

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• Are the Ir genes expressed by macrophages?

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• Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells.

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• Suppressor cell induction in vitro. III. Antigen-specific suppression by supernatants of suppressor cells.

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• T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

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• In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.

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• Antigenic phenotypes of T-cell subsets.

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• Current concepts of the antibody response: heterogeneity of lymphoid cells, interactions, and factors.

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• INVITRO STUDIES ON H-2 LINKED UNRESPONSIVENESS .1. NORMAL HELPER CELLS TO (T,G)-A-L AND GAT IN LOW AND NON-RESPONDER MICE

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• Two-gene control of T-helper cell induction.

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• Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.

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• Separation of suppressor and killer T cells by surgace phenotype.

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• Immunological effects of IgT synthesized by theta-positive cell lines.

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• Mechanisms of B-cell tolerance.

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• Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens.

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• Suppressor cell induction in vitro. II. Cellular requirements of suppressor cell induction.

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• Secondary cytotoxic allograft responses in vitro. III. The immunogenicity of allogeneic membrane fragments.

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• Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.

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• Enrichment of antigen-specific helper and suppressor T cells.

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• Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.

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• The role of macrophages in the generation of T helper cells. III. Influence of macrophage-derived factors in helper cell induction.

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• The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.

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• The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

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• T-T interaction in the generation of helper cells in vitro.

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• Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. I. Studies with 2,4-dinitrophenyl conjugates in vitro.

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• B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.

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• Role of macrophages in in vitro induction of T-helper cells.

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• Lack of requirement for cell cooperation in the antibody response to DNP conjugated to levan.

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• Role of T-cell immunoglobulin in cell cooperation, T-cell suppression, and antigenic competition.

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• Conditions for inducing T helper cells in vitro.

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• Role of antigen structure in the discrimination between tolerance and immunity by b cells.

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• Tolerance induction to a hapten protein conjugate in vivo: are suppressor T cells involved.

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• Mechanism of antigenic competition. II. Induction by specific T cell products.

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• T cell suppression in vitro. I. Role in regulation of antibody responses.

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• T cell suppression in vitro. II. Nature of specific suppressive factor.

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• Direct triggering of B lymphocytes by insolubilized antigen.

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• The effect of erythrocyte antigen structure on requirement for T cells.

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• Role of C3 in in vitro lymphocyte cooperation.

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• Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes.

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• Cell to cell interactions in the immune response.

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• Thymus-independent IgM and IgG responses in mice to flagellar antigens.

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• Synergy among thymocytes and peripheral lymph node cells in the in vitro generation of lymphocytes cytotoxic to alloantigens.

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• Histocompatibility-linked immune-response genes. What do they do?

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• The mechanism of antigenic competition. I. The macrophage as a site of a reversible block of T-B lymphocyte collaboration.

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• Relative affinity and avidity of the antigen-binding receptors of T and B rosette-forming cells.

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• Induction of specific helper cells in vitro.

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• Cell interactions in the immune response in vitro. VI. Mediation by T cell surface monomeric IgM.

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• Monospecificity of bone marrow-derived lymphocytes.

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• Induction fo B cell tolerance by antigen specific T cell factor.

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• Role of T-cell antigen-specific factor in T-B cooperation.

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• Cellular components of the immune system and their cooperation (T and B cells).

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• Studies on antibody affinity in mice.

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• The role of soluble factors in T-B cell collaboration.

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• Mechanism of antigen binding to receptor antibody in B cell immunity and tolerance in vitro.

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• Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.

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• Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.

  Journal article

  Feldmann M., (1972), The Journal of experimental medicine, 136, 737 - 760

• Humoral and cell mediated responses in vitro of spleen cells from mice with thymic aplasia (nude mice).

  Journal article

  Feldmann M. et al, (1972), The Australian journal of experimental biology and medical science, 50, 651 - 660

• Induction of immunity and tolerance in vitro by hapten protein conjugates. 3. Hapten inhibition studies of antigen binding to B cells in immunity and tolerance.

  Journal article

  Feldmann M., (1972), The Journal of experimental medicine, 136, 532 - 545

• Mechanisms at the cellular level during induction of high zone tolerance in vitro.

  Journal article

  Diener E. and Feldmann M., (1972), Cellular immunology, 5, 130 - 136

• Cellular basis of antibody production.

  Journal article

  Feldmann M. and Nossal GJ., (1972), The Quarterly review of biology, 47, 269 - 302

• Cell-mediated immune response in vitro. 3. The requirement for macrophages in cytotoxic reactions against cell-bound and subcellular alloantigens.

  Journal article

  Wagner H. et al, (1972), The Journal of experimental medicine, 136, 331 - 343

• Cell interactions in the immune response in vitro. 3. Specific collaboration across a cell impermeable membrane.

  Journal article

  Feldmann M. and Basten A., (1972), The Journal of experimental medicine, 136, 49 - 67

• Cell interactions in the immune response in vitro. I. Metabolic activities of T cells in a collaborative antibody response.

  Journal article

  Feldmann M. and Basten A., (1972), European journal of immunology, 2, 213 - 224

• Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration.

  Journal article

  Feldmann M., (1972), The Journal of experimental medicine, 135, 1049 - 1058

• Dynamic aspects of antigen binding to B cells in immune induction.

  Journal article

  Wilson JD. and Feldmann M., (1972), Nature: New biology, 237, 3 - 5

• Specific collaboration between T and B lymphocytes across a cell impermeable membrane in vitro.

  Journal article

  Feldmann M. and Basten A., (1972), Nature: New biology, 237, 13 - 15

• Cell-mediated immune response in vitro. II. The role of thymus and thymus-derived lymphocytes.

  Journal article

  Wagner H. et al, (1972), Cellular immunology, 4, 39 - 50

• Induction of immunity and tolerance in vitro by hapten protein conjugates. I. The relationship between the degree of hapten conjugation and the immunogenicity of dinitrophenylated polymerized flagellin.

  Journal article

  Feldmann M., (1972), The Journal of experimental medicine, 135, 735 - 753

• Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin.

  Journal article

  Feldmann M., (1972), European journal of immunology, 2, 130 - 137

• Cell-mediated immune response in vitro. I. A new in vitro system for the generation of cell-mediated cytotoxic activity.

  Journal article

  Wagner H. and Feldmann M., (1972), Cellular immunology, 3, 405 - 420

• Antibody-mediated suppression of the immune response in vitro. IV. The effect of antibody fragments.

  Journal article

  Feldmann M. and Diener E., (1972), Journal of immunology (Baltimore, Md. : 1950), 108, 93 - 101

• Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages.

  Journal article

  Feldmann M. and Nossal GJ., (1972), Transplantation reviews, 13, 3 - 34

• Relationship between antigen and antibody-induced suppression of immunity.

  Journal article

  Diener E. and Feldmann M., (1972), Transplantation reviews, 8, 76 - 103

• The detection of autoantibody-forming cells. I. An assay for plaque-forming cells to the basic protein of myelin in guinea-pigs.

  Journal article

  Lennon V. and Feldmann M., (1972), International archives of allergy and applied immunology, 42, 627 - 640

• The detection of autoantibody-forming cells. II. Cells in lymph nodes and central nervous system containing antibody to myelin basic protein.

  Journal article

  Lennon V. et al, (1972), International archives of allergy and applied immunology, 43, 749 - 758

• The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro.

  Journal article

  Feldmann M. and Palmer J., (1971), Immunology, 21, 685 - 699

• Antibody-mediated suppression of the immune response in vitro. 3. Low zone tolerance in vitro.

  Journal article

  Feldmann M. and Diener E., (1971), Immunology, 21, 387 - 404

• The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

  Journal article

  Feldmann M. and Easten A., (1971), The Journal of experimental medicine, 134, 103 - 119

• Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro.

  Journal article

  Feldmann M. and Diener E., (1971), Nature: New biology, 231, 183 - 184

• Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

  Journal article

  Feldmann M., (1971), Nature: New biology, 231, 21 - 23

• Induction of low-zone tolerance in vitro.

  Journal article

  Diener E. and Feldmann M., (1971), Transplantation proceedings, 3, 663 - 665

• Antibody-mediated suppression of the immune response in vitro. II. A new approach to the phenomenon of immunological tolerance.

  Journal article

  Diener E. and Feldmann M., (1970), The Journal of experimental medicine, 132, 31 - 43

• Antibody-mediated suppression of the immune response in vitro. I. Evidence for a central effect.

  Journal article

  Feldmann M. and Diener E., (1970), The Journal of experimental medicine, 131, 247 - 274

• Assemblée générale du 13 Mars 1970

  Journal article

  (1970), Bulletin de la Société Botanique de France, 117, 177 - 177

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