Professor of Musculoskeletal Biology
- Consultant rheumatologist
- Director, Centre for Osteoarthritis Pathogenesis
Tonia Vincent studied medicine at UCL, qualifying in 1993. She trained as a junior doctor in London, later specialising in Rheumatology. In 1998 she took time out to do a PhD at the Kennedy Institute of Rheumatology under Professor Jeremy Saklatvala (awarded 2002). She continued at the Kennedy Institute as a Wellcome Trust clinician scientist and subsequently as an Arthritis Research UK Senior Fellow. In 2012 the Kennedy Institute moved to the University of Oxford and she was appointed Professor of Musculoskeletal Biology.
She directs the Centre for OA Pathogenesis funded by Versus Arthritis. Her research interests include pathways that drive mechanosensitive responses in cartilage, the role of the pericellular matrix in determining these responses and how they modulate osteoarthritis in vivo. Her work is funded by Versus Arthritis, MRC, ERC and the Kennedy Trust for Rheumatology Research. She continues to be clinically active, running both osteoarthritis clinics and the multidisciplinary Marfan Syndrome clinic.
IFT88 maintains profound influence in the post-natal joint, through joint maturation, and during adult homeostasis acting as the cartilage mechanoeffector
Coveney C. et al, (2019)
von Loga IS. et al, (2019), Ann rheum dis, 78, 672 - 675
The presence of blood in the joint and the immediate molecular response in SF are independently associated with worse clinical outcomes at 2 years after human knee injury
Garriga C. et al, (2019)
Chanalaris A. et al, (2019), Am j pathol, 189, 632 - 647
Vincent TL. and Wann AKT., (2019), J physiol, 597, 1271 - 1281