Contact information
https://orcid.org/0000-0003-1322-2027
Botnar Institute for Musculoskeletal Sciences, Old Rd, Headington, Oxford OX3 7LD
she/her
Loren Kell
DPhil (Oxon), BSc (Hons)
Postdoctoral Researcher in Translational Immunology
I am a postdoctoral researcher in the Translational Pharmacology (Fullerton) Group at the Botnar Institute. I am mainly interested in understanding differences in human immunity based on sex and biological ageing. Following my undergraduate degree at University College London, I obtained my DPhil/PhD from Oriel College, Oxford, where I worked on describing the geroprotective effects of mTOR inhibitors on immune DNA damage with Ghada Alsaleh, Lynne Cox, and Katja Simon. In my current role, I am leveraging human immune challenge models using the KLH neoantigen to explore the generation of resident memory T cells.
Key publications
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Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage
Preprint
Kell L. et al, (2025)
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The central role of DNA damage in immunosenescence.
Journal article
Kell L. et al, (2023), Front aging, 4
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The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine
Journal article
Kell DB. et al, (2025), Journal of reproductive immunology, 171
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Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System
Preprint
Nunes M. et al, (2025)
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Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.
Preprint
Alsaleh G. et al, (2025)