Mohammad H. Kazeroun
Research Assistant in Computational Biology
Research focus and interests
Mohammad Kazeroun leverages his background in evolutionary and computational biology to investigate cancer evolution through tumor cell phylogeny. His research focuses on intra-tumoral heterogeneity and subclonal growth, which contribute to drug resistance in cancers like Multiple Myeloma. As part of the Oxford Translational Myeloma Centre (OTMC), he works to unravel the genomic complexity of myeloma. Mohammad co-developed the Myeloma Genome Project Panel (MGPP), a comprehensive targeted genomics panel for myeloma profiling, and is currently developing a pipeline to integrate this approach into standard NHS clinical practice. His expertise lies in analysing Whole Genome Sequencing (WGS) and multi-omics data to identify copy number aberrations, translocations, and single-nucleotide variant (SNV) mutations for genomic profiling, enabling risk assessment, diagnosis, and prognosis for patients.
Recent publications
Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA) RADAR trial in newly diagnosed transplant eligible patients
Journal article
Ramasamy K. et al, (2025), Blood, 146, 98 - 98
Long-read RNA sequencing of first multiple myeloma patient cohort reveals landscape of variant expression in newly diagnosed patients from the UKMRA RADAR trial
Journal article
Hudson-Lund B. et al, (2025), Blood, 146, 2141 - 2141
NGS-based targeted sequencing guides risk-adapted and molecularly targeted therapy decisions in multiple myeloma.
Journal article
Agarwal G. et al, (2025), Br J Haematol, 207, 2167 - 2172
nti-Adhesion Properties of KTX-1001, a Selective NSD2/MMSET Inhibitor, Enhance Carfilzomib Sensitivity in Multiple Myeloma
Journal article
Nandana D. et al, (2025), Clinical Lymphoma Myeloma and Leukemia, 25, S213 - S214
Quantitative liver function imaging and whole genome sequencing - Effective modalities for a new era in personalised decision-making for operable colorectal liver metastases?
Journal article
Welsh F. et al, (2025), HPB (Oxford), 27, 553 - 561