Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Aspirin could be used as an anti-inflammatory drug, bringing relief to the thousands who suffer with shoulder pain, researchers at NDORMS have found.

Head of Department Professor Andrew Carr assesses a patient with shoulder pain
Head of Department Professor Andrew Carr assesses a patient with shoulder pain

In a study published in the journal Science Translational Medicine, our scientists looked at tendons taken from patients suffering from shoulder pain.

Dr Stephanie Dakin said: 'Shoulder pain is the third most common problem seen by orthopaedics specialists and with an aging population we will see more of this. There are various treatment options, from physiotherapy to drugs and injections and even surgery. Success rates can be variable. We wanted to understand the underlying processes that cause the problem.

Dr Dakin first developed her interest in the issue as a vet treating horses with tendon injuries, which can be life threatening in the animals. After completing a PhD researching inflammation in equine tendon disease, she has been funded by Arthritis Research UK to spend the last two years developing her findings and looking at how they can be applied to people as well.

She explained: 'The focus of this current work is to investigate inflammation in shoulder tendon injuries in groups of NHS patients at the Oxford University Hospitals. The purpose of this research is to improve understanding of the role of inflammation in tendon disease to find therapeutic targets – elements of the condition that can be targeted with drugs to relieve or cure it.'

The team found that the processes creating and sustaining inflammation were different in early and late stage tendon disease. They also found processes that appear to be responsible for recovery from tendon pain after treatment. A key finding was that aspirin, that staple of household medicine cabinets, could be an effective treatment.

Dr Dakin said: 'Looking at cells in the laboratory, we found that low dose aspirin has the potential to resolve tendon inflammation. We will now be conducting a clinical trial to investigate if low dose aspirin can help to prevent tendon injuries or treat patients with early stage tendon disease.'

You can read the full paper here.

Similar stories

COVID-19’s high blood clot risk

A recent study of patient health records found that around 1 in 100 people with COVID-19 had a venal or arterial thrombosis, with rates higher still among males, and particularly for those hospitalised.

REF 2021 results for medical research in Oxford

Today the UK Funding Bodies have published the outcomes of the recent national research assessment exercise, the Research Excellence Framework (REF) 2021.

Nurses' Day 2022

Today marks Nurses' Day 2022. This year's theme is #BestofNursing, so we chatted to some of our amazing Research Nurses about what the Best of Nursing means to them.

Rethinking pain management after injury

NDORMS researchers are to study whether a pain management treatment using cognitive behavioural therapy will improve recovery for people who have had a major leg injury.

Breakthrough in treatment for Dupuytren’s disease

Injection of the anti-TNF drug adalimumab into Dupuytren’s disease nodules is effective in reducing nodule hardness and nodule size.

Associate Professor Afsie Sabokbar re-elected to the Medical Sciences Skills Training Team

Associate Professor and Director of Graduate Studies, Afsie Sabokbar, has been re-elected to the Medical Sciences Skills Training Team for the third time as Director of the Skills Training and Researcher Development. We chatted to her to find out more about what the team do, and what Afsie’s role is.