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Publications

Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.

Barton A. et al, (2022), Infect immun

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.

Vecellio M. et al, (2021), Arthritis rheumatol, 73, 980 - 990

From the Genetics of Ankylosing Spondylitis to New Biology and Drug Target Discovery.

Nancy Z. et al, (2021), Front immunol, 12

Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).

Chen L. et al, (2020), Mol cell proteomics, 19, 871 - 883

Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).

Chen L. et al, (2020), Mol cell proteomics, 19, 871 - 883

From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis

Fang H. et al, (2020), The lancet rheumatology, 2, e50 - e62

GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis.

Shi H. et al, (2020), Front immunol, 11

A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Fang H. et al, (2019), Nat genet, 51, 1082 - 1091

OP0231?Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region

(2018), Annals of the rheumatic diseases

Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases.

Hammitzsch A. et al, (2018), Sci rep, 8

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V. et al, (2018), Cell rep, 25, 798 - 810.e6

Is Behçet's disease a 'class 1-opathy'? The role of HLA-B*51 in the pathogenesis of Behçet's disease.

Giza M. et al, (2018), Clin exp immunol, 191, 11 - 18

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

Al-Mossawi MH. et al, (2017), Nat commun, 8

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

Schwerd T. et al, (2017), J exp med, 214, 2547 - 2562

Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function.

Wang XW. et al, (2017), Clin exp dermatol, 42, 622 - 631

GTP cyclohydrolase accelerates tumor progression through interaction with angiopoietin-1 in stromal fibroblasts and activation of Tie2 on breast cancer cells

CAI S. et al, (2017)

miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis.

Chen L. et al, (2017), Ann rheum dis, 76, 620 - 625

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

Chen L. et al, (2017), Ann rheum dis, 76, 593 - 601

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.

Roberts AR. et al, (2016), Ann rheum dis, 75, 2150 - 2156

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Chen L. et al, (2016), Ann rheum dis, 75, 916 - 923

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