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Our group is currently studying in detail the phenotype and function of type 17 responses in AS. 

The type 17/23 axis is now an important target for therapeutic drug and antibody development. We are also working on small molecule inhibitors of ERAP1, of the transcription factor ROR gamma T and of the (epigenetic) bromodomain readers and transcriptional co-activators CBP and p300. Our data show that all can inhibit Type17 responses in vitro.