Daniel O'Connor
BSc AFHEA MSc DPhil (OXON)
Associate Professor | Head of Bioinformatics
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
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RNA2HLA: HLA-based quality control of RNA-seq datasets.
Journal article
Chelysheva I. et al, (2021), Brief bioinform, 22
Recent publications
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Association between disease severity and co-detection of respiratory pathogens in infants with RSV infection
Preprint
Lin G-L. et al, (2023)
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Correction to: Febrile illness in high-risk children: a prospective, international observational study.
Journal article
van der Velden FJS. et al, (2023), Eur j pediatr, 182, 555 - 556
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Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults.
Journal article
Green C. et al, (2023), Clin exp immunol