Research groups
Daniel O'Connor
BSc MSc DPhil
Postdoctoral Researcher
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
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RNA2HLA: HLA-based quality control of RNA-seq datasets
Journal article
Chelysheva I. et al, (2021), Briefings in bioinformatics
Recent publications
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Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease.
Journal article
Hoggart C. et al, (2021), Eur j hum genet
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RNA2HLA: HLA-based quality control of RNA-seq datasets
Journal article
Chelysheva I. et al, (2021), Briefings in bioinformatics
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Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
Journal article
Voysey M. et al, (2021), Lancet, 397, 881 - 891