Daniel O'Connor
BSc AFHEA MSc DPhil (OXON)
Associate Professor | Head of Bioinformatics
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
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Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.
Journal article
Mentzer AJ. et al, (2022), Nat med
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Molecular correlates of vaccine-induced protection against typhoid fever.
Journal article
Zhu H. et al, (2023), J clin invest
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Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.
Journal article
O'Connor D. et al, (2020), Mol syst biol, 16
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Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.
Journal article
O'Connor D. et al, (2019), Cell rep, 27, 3241 - 3253.e4
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RNA2HLA: HLA-based quality control of RNA-seq datasets.
Journal article
Chelysheva I. et al, (2021), Brief bioinform, 22
Recent publications
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Relationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study.
Journal article
Shah P. et al, (2023), Lancet reg health eur, 32
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Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens.
Journal article
Willems E. et al, (2023), Iscience, 26
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Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature.
Journal article
Habgood-Coote D. et al, (2023), Med
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Molecular correlates of vaccine-induced protection against typhoid fever.
Journal article
Zhu H. et al, (2023), J clin invest
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Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature.
Journal article
Jackson HR. et al, (2023), J pediatric infect dis soc, 12, 322 - 331