BSc AFHEA MSc DPhil (OXON)
University Research Lecturer | Senior Bioinformatician
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
RNA2HLA: HLA-based quality control of RNA-seq datasets
Chelysheva I. et al, (2021), Briefings in bioinformatics
Divergent trajectories of antiviral memory after SARS-CoV-2 infection.
Tomic A. et al, (2022), Nat commun, 13
Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen.
Sheerin D. et al, (2021), Bmc genomics, 22
Publisher Correction: Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus.
Lin G-L. et al, (2021), Nat commun, 12