Nicholas Ilott

Postdoctoral Research Scientist

My interests lie in the interplay between the host and commensal microbes of the gut in the context of inflammation. Inflammation is capable of driving changes in the gut niche that may lead to expansion of bacterial taxa or changes in microbial function that reflect adaptive advantage to the inflamed environment. These changes are likely to feedback onto the immune system to promote either exacerbation or resolution of disease. To explore these host-microbe relationships I am using a variety of high-throughput methods (microarrays, Next Generation Sequencing) in functional genomics and metagenomics analyses. My scientific research is tied in with my interest in employing cutting-edge sequencing technologies from Illumina short-read sequencing to the latest in long-read sequencing - Oxford Nanopore MinION platform.

Recent Publications

Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.
Ilott NE. et al, (2016), The ISME journal, 10, 2389 - 2404
Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.
Harrison OJ. et al, (2015), Mucosal Immunology, 8, 1226 - 1236
Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
Ilott NE. et al, (2015), Nature Communications, 6, 6814 - 6814
Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
Heward JA. et al, (2014), IMMUNOLOGY, 143, 110 - 110
CGAT: computational genomics analysis toolkit.
Sims D. et al, (2014), Bioinformatics (Oxford, England), 30, 1290 - 1291

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