Contact information
Botnar Research Centre, Old Road, Headington, Oxford OX3 7LD
Research groups
Sophie Reynolds
Clinical Trial Manager
I joined SITU (NDS) in February 2023 as a Clinical Trial Manager for working on two studies, CARE and ENDO-CARE. The CARE Trial aims to find out how practical it is for people carrying excess weight to lose weight after a bowel cancer diagnosis and while waiting for surgery. Physical fitness and well-controlled blood sugar are linked with fewer complications after surgery. For people carrying excess weight, losing weight improves both of the above, so it could reduce complications after surgery. This will help us to see, in future research, whether losing weight is of benefit to a larger number of patients. ENDO-CARE is a sister study to CARE undertaken with participants who are diagnosed with endometrial cancer.
Prior to joining SITU, I was a Quality Assurance Administrator for the Early Phase and Late Phase Oncology and Haematology Research Teams at the Churchill Hospital, Oxford and as a Senior Data Manager for the Early Phase Clinical Trials Unit based within the Department of Oncology, University of Oxford.
Recent publications
Intentional weight loss before endometrial cancer surgery to support postoperative recovery: the ENDO-CARE feasibility randomised controlled trial
Journal article
Koutoukidis DA. et al, (2026), The Lancet Obstetrics, Gynaecology, & Women’s Health
Preoperative Weight Loss in Patients With Excess Weight and Colorectal Cancer: The CARE Feasibility Randomized Clinical Trial.
Journal article
Koutoukidis DA. et al, (2025), JAMA Netw Open, 8
SP6.15 Pre-operative intentional weight loss is safe, feasible, and preserves fat-free mass in patients with excess weight undergoing colorectal cancer surgery: a multi-centre randomised controlled trial
Journal article
Koutoukidis D. et al, (2025), British Journal of Surgery, 112