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The latest updates on our research and how it is improving people’s lives.

Kennedy scientists join world-leading researchers in ‘pivotal’ study to help arthritis patients to live drug free

The prospect of long-lasting drug-free remission for children and adults living with inflammatory arthritis is a step closer to becoming a reality, thanks to a new collaboration.

Rapamycin helps protect immune cells against DNA damage

New research carried out by Dr Loren Kell at NDORMS, has demonstrated for the first time that rapamycin can reduce DNA damage in immune cells, a hallmark of ageing.

NDORMS and NDCN collaborate with Oxford University Hospitals to form the Kadoorie Institute for Trauma, Emergency and Critical Care

Oxford Trauma and Emergency Care at Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), along with the Critical Care Research Team at Nuffield Department of Clinical Neurosciences (NDCN) have formally become a new Institute within the University of Oxford: the Kadoorie Institute for Trauma, Emergency and Critical Care.

ADHD medication use rises sharply across Europe, driven by growth among adults

The use of medications for Attention-Deficit Hyperactivity Disorder (ADHD) has increased substantially across Europe over the past decade, with the steepest rises seen among adults - particularly women - according to a large population-based study published in The Lancet Regional Health – Europe.

Surgery unnecessary for elbow fractures in children new study finds

Researchers at NDORMS have found that surgery for a displaced medial epicondyle fracture of the elbow in children offers no clinical benefit compared to non-surgical care. The findings could have significant implications for treatment and offer huge cost savings to the NHS.

What determines the fate of a T cell?

Research led by Dr Mariana Borsa at the Kennedy Institute has found that a cellular housekeeping mechanism called autophagy plays a major role in ensuring that T cells generate diverse progenies upon cell division. The findings, published in Nature Cell Biology, could help boost vaccine response in older adults.

Kennedy researchers contribute to UK-wide AI and bioscience training initiative

Together with a group of Oxford researchers, Mark Coles, Professor of Immunology at the Kennedy Institute, will co-lead the Enabling Next-generation AI for a Bioscience-Led Economy (ENAIBLE) initiative.

World-leading researchers unite for ‘pivotal’ study to help children and adults with arthritis to live drug free

The prospect of long-lasting drug-free remission for children and adults living with inflammatory arthritis is a step closer to becoming a reality, thanks to a new collaboration which includes world-leading researchers from the Kennedy Institute.

Addressing antimicrobial resistance through advanced UTI models

A collaborative study, which includes contributions from NDORMS researchers Aaron Crowther and supervisor Dario Carugo, explores new ways to model bladder biology and infection, allowing evaluation of antimicrobial therapies under physiologically relevant conditions.

Can AI models rival humans in anonymising patient information from electronic health records?

Researchers from the University of Oxford have benchmarked artificial intelligence (AI) tools capable of automatically removing personal information from patient electronic health records (EHRs) in a key step towards enabling large-scale, confidential medical research.

Two NDORMS groups join the PROBE Initiative to advance osteoarthritis research

Two research groups at NDORMS have joined the newly launched PROBE initiative, contributing their expertise to a major European collaboration focused on improving the understanding, diagnosis and treatment of osteoarthritis.

New study to address heavy menstrual bleeding in low-resource settings

Sara Khalid’s Planetary Health Informatics group has been awarded funding from the Gates Foundation’s Grand Challenges initiative to investigate the epidemiology and impact of heavy menstrual bleeding in low-resource settings.

New study highlights benefit of surgery for children with cerebral palsy

A new national study has found that single-event multi-level surgery (SEMLS) helps straighten the legs and improves walking ability in children with cerebral palsy.

Maria Kyriazi wins Young Star Award at the Greek International Women Awards

NDORMS DPhil student Maria Kyriazi has won the prestigious Young Star Award at the fourth Greek International Women Awards in Athens.

Study finds no increased safety risk for obese patients undergoing shoulder replacement surgery

Higher BMI is not linked to increased risk of death or other complications following shoulder replacement surgery, according to a new study by Epaminondas Markos Valsamis from NDORMS, University of Oxford.

Both total and partial knee replacements deliver lasting benefits at 10 years

New research from a randomised clinical trial provides the strongest long-term evidence yet comparing partial (PKR) and total (TKR) knee replacements for patients with osteoarthritis. Published in The Lancet Rheumatology, the study shows both PKR and TKR being equally effective and offering similar clinical outcomes.

Oxford and GSK launch Experimental Medicine Collaboration

GSK invests £10 million over five years to establish the Experimental Medicine Collaboration with the University of Oxford.

Shaping immunity - the secrets behind the shape of neutrophils

Researchers at the Kennedy Institute have provided the most comprehensive overview to date of how the distinctive segmented nucleus of neutrophils influences their function in health and disease.

Oxford researchers to redefine new human-based research models of pain

Professor Tonia Vincent is part of an interdisciplinary team from Oxford University leading a major new initiative which aims to redefine human-based research models for greater understanding of disease and the acceleration of new medicines.

New Microbiome Innovation Network to drive UK Bioscience Research

Researchers from the Kennedy Institute are part of a UK-wide consortium that has been awarded a £644K BBSRC Network Grant to establish the Microbiome Innovation Network (Microbiome-Net).

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