Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A recent publication from the Powrie group at the Kennedy Institute of Rheumatology has described a novel mechanism by which the commensal pathogen Heliobacter hepaticus maintains its niche in the intestinal environment.

None

The work, led by Dr Camille Danne in Prof Fiona Powrie’s group, describes the effects of a newly described H. hepaticus secreted polysaccharide on intestinal macrophages, promoting a pro-repair and anti-inflammatory gene signature and effector phenotype.  

The discovery of this mechanism provides a better understanding of the potential means of molecular crosstalk between key host cells in the gut and commensal bacteria.  By further understanding the pathways that promote tolerance and normal homeostasis, these same pathways can potentially be enhanced in order to restore balance after disruptive challenges and interventions such as antibiotic treatment, stress and food allergy, as well as to re-establish a balanced host–microbe dialogue in chronic inflammation.

The study, carried out in collaboration with Prof Simon Arthur’s group in the University of Dundee, was published in Cell Host and Microbe earlier this month and can be accessed here, as was a commentary on the paper from the Kullberg lab which can be found here

Similar stories

Matthew Costa elected Fellow of Academy of Medical Sciences

Matthew Costa, Professor of Orthopaedic Trauma Surgery at NDORMS, has been elected a Fellow of the Academy of Medical Sciences.

COVID-19’s high blood clot risk

A recent study of patient health records found that around 1 in 100 people with COVID-19 had a venal or arterial thrombosis, with rates higher still among males, and particularly for those hospitalised.

REF 2021 results for medical research in Oxford

Today the UK Funding Bodies have published the outcomes of the recent national research assessment exercise, the Research Excellence Framework (REF) 2021.

Nurses' Day 2022

Today marks Nurses' Day 2022. This year's theme is #BestofNursing, so we chatted to some of our amazing Research Nurses about what the Best of Nursing means to them.

Rethinking pain management after injury

NDORMS researchers are to study whether a pain management treatment using cognitive behavioural therapy will improve recovery for people who have had a major leg injury.

Breakthrough in treatment for Dupuytren’s disease

Injection of the anti-TNF drug adalimumab into Dupuytren’s disease nodules is effective in reducing nodule hardness and nodule size.