Oxford BRC Stats Hub Lunchtime Seminar Series: Trial designs for early phase trials
Alexander Ooms
Wednesday, 06 November 2024, 1pm to 1.30pm
Hosted by octru-stats@ndorms.ox.ac.uk
This is the third in a series of lunchtime seminars organised by the Oxford BRC Statistics Hub. Each seminar is 20 minutes long followed by 10 minutes of Q&A, and will be held via Microsoft Teams. These seminars are open to all in the University of Oxford and Oxford University Hospitals NHS Trust.
Trial designs for early phase trials
Alexander Ooms - OCTRU Senior Medical Statistician
Early phase clinical trials are critical for assessing the safety, dosage, and preliminary efficacy of new treatments. This seminar will outline some available designs in Phase I and Phase II settings.
Phase I trials primarily focus on determining safe dosages and identifying side effects using broad categories of ‘rule-based’ or ‘model-based’ dose escalation methods.
Phase II trials typically aim to give an early indication of treatment efficacy and further assess safety via single-arm or randomised controlled trials. Adaptive, occasionally Bayesian, designs are popular in the early phase setting and some examples of adaptive designs will be discussed.
No registration required.
Click here to join the session.
External Training
These links lead to a variety of clinical research related resources, training opportunities and conferences offered by external organisations – OCTRU does not necessarily endorse the links – this is offered only as a resource for individuals to use when looking for wider opportunities.
Note: We endeavour to keep this page up to date, however if a link is broken please can you let the admin team know on octrutrialshub@ndorms.ox.ac.uk
Training Opportunities
Training provided in Clinical Trials by the University of Oxford
Training in Research Integrity & Ethics
Research Governance, Ethics & Assurance Team (RGEA)
UKCRC Registered Clinical Trial Units
Monitoring of clinical trials - Online Training Modules
Resources about Human Tissue Act
Resources about Public Engagement
Health Research Authority (HRA)
National Institute of Health Research (NIHR) including NIHR Learn
Integrated Research Application System (IRAS)
NIHR Research & Design Services (RDS South Central)
This team have regular emails with links to training opportunities offered by themselves and other – follow this LINK to register for these alerts.
NIHR Learning for Involvement - training and resources dedicated to learning and development for public involvement in health and social care research
NIHR Associate Principal Investigator Scheme Resources Site
E-Learning
Training offered on Good Research Practice, including GDPR, Human Tissue legislation, IRAS - follow this LINK
National Institute of Health Research (NIHR Learn)
Online training courses for those working on trials, including those with an ac.uk email address. Courses include Introduction to GCP and refresher GCP training, diversity and inclusion training, and more - follow this LINK
LinkedIn Learning
Conferences
Biannual conference for researchers and practitioners to present the very latest in trials methodology research
Society for Clinical Trials (US organisation)
Annual conference in the US for those working in trials