Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Interleukin-6 (IL-6) and interleukin-11 (IL-11) are known to influence osteoclast formation and bone resorption. In order to determine whether IL-6 and IL-11 could independently support human osteoclast formation, these factors were added to cultures of human peripheral blood mononuclear cells of the monocyte (CD14(+)) fraction in the presence of macrophage colony-stimulating factor (M-CSF). Under these conditions, IL-6 and IL-11 induced the formation of multinucleated cells which were positive for TRAP, VNR, and calcitonin receptor and capable of lacunar resorption. Osteoclastogenesis induced by IL-6 and IL-11 was inhibited by the addition of an anti-gp130 antibody but not by osteoprotegerin. These results indicate that IL-6 and IL-11, which are thought to play a role in several osteolytic bone disorders, are directly capable of inducing osteoclast formation by a RANKL-independent mechanism.

Original publication

DOI

10.1016/s8756-3282(02)00915-8

Type

Journal article

Journal

Bone

Publication Date

01/2003

Volume

32

Pages

1 - 7

Addresses

Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK.

Keywords

Cells, Cultured, Osteoclasts, Humans, Acid Phosphatase, Isoenzymes, Carrier Proteins, Membrane Glycoproteins, Recombinant Proteins, Interleukin-6, Interleukin-11, Adult, Middle Aged, Female, Male, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Tartrate-Resistant Acid Phosphatase