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Two diphosphonates containing the P-C-P bond, Cl(2)C(PO(3)HNa)(2), and H(2)C(PO(3)HNa)(2) retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.

Original publication

DOI

10.1126/science.165.3899.1262

Type

Journal article

Journal

Science

Publication Date

19/09/1969

Volume

165

Pages

1262 - 1264

Keywords

Animals, Binding Sites, Bone Resorption, Culture Techniques, Hydroxyapatites, Mice, Organophosphonates, Parathyroid Glands, Rats, Solutions, Thyroidectomy, Tissue Extracts