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Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondrocytes include tumour necrosis factor-alpha, polyriboinosinic: polyribocytidylic acid and bacterial lipopolysaccharide. Interleukin 6 production is not inhibited by prostaglandin E2 but may be partially dependent on prostaglandin E2 production. Using an antiserum to interleukin 6 we have demonstrated that the production of prostaglandin E2 under basal conditions and in response to interleukin 1 is probably not mediated by interleukin 6.

Original publication

DOI

10.1016/0006-291x(90)90988-y

Type

Journal article

Journal

Biochem biophys res commun

Publication Date

14/02/1990

Volume

166

Pages

1163 - 1170

Keywords

Cartilage, Articular, Cells, Cultured, Concanavalin A, Dinoprostone, Escherichia coli, Humans, Immune Sera, Indomethacin, Interleukin-1, Interleukin-6, Lipopolysaccharides, Neutralization Tests, Poly I-C, Recombinant Proteins, Tumor Necrosis Factor-alpha