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Two diphosphonates containing the P-C-P bond, CH(3)C(OH)(PO(3)HNa)(2) and H(2)C(PO(3)HNa)(2), inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D(3). The diphosphonates therefore have effects similar to those described for compounds containing the P-O-P bond but are active when administered orally.

Original publication

DOI

10.1126/science.165.3899.1264

Type

Journal article

Journal

Science

Publication Date

19/09/1969

Volume

165

Pages

1264 - 1266

Keywords

Animals, Aortic Diseases, Calcinosis, Cholecalciferol, Crystallization, Diphosphates, Hydrogen-Ion Concentration, Organophosphonates, Phosphates, Rats, X-Ray Diffraction