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The human interferon-beta-inducing 22K factor has been shown to have structural homologies with interleukin-1 beta (IL-1 beta) and some of the activities attributed to IL-1. We have shown that 22K factor, purified to homogeneity and endotoxin free, has connective tissue cell stimulating activities, indicating that these activities are due to a naturally occurring species of IL-1 beta and not contaminating factors. 22K factor stimulated the production of prostaglandin E, caseinase activity and plasminogen activator activity in human articular chondrocytes in culture. This cell system appears highly sensitive to 22K factor activity. 22K factor also stimulated the resorption of bovine nasal cartilage and neonatal mouse calvaria.

Original publication

DOI

10.1016/s0006-291x(86)80297-2

Type

Journal article

Journal

Biochem biophys res commun

Publication Date

30/09/1986

Volume

139

Pages

1150 - 1157

Keywords

Animals, Biological Assay, Bone Resorption, Cartilage, Articular, Cattle, Cell Division, Connective Tissue Cells, Endopeptidases, Humans, Interleukin-1, Metalloendopeptidases, Molecular Weight, Peptide Hydrolases, Plasminogen Activators, Prostaglandins E