Comparative effects of an antiviral drug, inosiplex, and diphosphonates in Paget's disease of bone.
Kanis JA., Preston CJ., Beard DJ., Beneton M., Harris S., Russell RG.
The effects of the antiviral agent, inosiplex, were assessed in four patients with Paget's disease of bone. Treatment for 6 months did not suppress disease activity as judged by serum alkaline phosphatase and hydroxyprolinuria, and viral inclusions persisted in the one patient from whom a bone biopsy was taken. These results contrasted markedly with the suppressive effects of diphosphonate treatment in these same patients.