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The effects of the antiviral agent, inosiplex, were assessed in four patients with Paget's disease of bone. Treatment for 6 months did not suppress disease activity as judged by serum alkaline phosphatase and hydroxyprolinuria, and viral inclusions persisted in the one patient from whom a bone biopsy was taken. These results contrasted markedly with the suppressive effects of diphosphonate treatment in these same patients.

Original publication

DOI

10.1016/8756-3282(85)90309-6

Type

Journal article

Journal

Bone

Publication Date

1985

Volume

6

Pages

69 - 72

Keywords

Alkaline Phosphatase, Clodronic Acid, Diphosphonates, Etidronic Acid, Humans, Hydroxyproline, Inclusion Bodies, Viral, Inosine, Inosine Pranobex, Osteitis Deformans