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Cultured adherent human mononuclear cells produce factor(s) which stimulate the release of calcium from new-born mouse calvaria in organ culture. This stimulation of bone resorption is accompanied by an inhibition of the incorporation of [3H]proline into collagen which is independent of increased prostaglandin production by the bone. When human osteoblast-like cells are treated with conditioned medium from human mononuclear cells, collagen accounts for a decreased proportion of the protein synthesised. This effect on matrix synthesis is not accompanied by an inhibitory action of the monocyte-conditioned medium preparations on net cell proliferation. In human osteoblast-like cell cultures, partially purified human interleukin 1 also inhibits the production of the bone-specific protein osteocalcin in a dose-dependent fashion. These observations are consistent with the hypothesis that products of human monocytes similar to, or identical with, human interleukin 1 may be important regulators of bone metabolism and may contribute to the bone loss seen in diseases such as chronic rheumatoid arthritis.

Original publication

DOI

10.1016/0304-4165(84)90212-5

Type

Journal article

Journal

Biochim biophys acta

Publication Date

07/09/1984

Volume

801

Pages

58 - 65

Keywords

Animals, Animals, Newborn, Anti-Inflammatory Agents, Bone Resorption, Bone and Bones, Calcium-Binding Proteins, Cells, Cultured, Collagen, Culture Media, DNA Replication, Guanidines, Humans, Indomethacin, Interleukin-1, Mice, Monocytes, Osteocalcin, Proline, Protein Biosynthesis