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Cultured adherent human mononuclear cells produce factor(s) which stimulate the release of calcium from new-born mouse calvaria in organ culture. This stimulation of bone resorption is accompanied by an inhibition of the incorporation of [3H]proline into collagen which is independent of increased prostaglandin production by the bone. When human osteoblast-like cells are treated with conditioned medium from human mononuclear cells, collagen accounts for a decreased proportion of the protein synthesised. This effect on matrix synthesis is not accompanied by an inhibitory action of the monocyte-conditioned medium preparations on net cell proliferation. In human osteoblast-like cell cultures, partially purified human interleukin 1 also inhibits the production of the bone-specific protein osteocalcin in a dose-dependent fashion. These observations are consistent with the hypothesis that products of human monocytes similar to, or identical with, human interleukin 1 may be important regulators of bone metabolism and may contribute to the bone loss seen in diseases such as chronic rheumatoid arthritis.

Original publication




Journal article


Biochim biophys acta

Publication Date





58 - 65


Animals, Animals, Newborn, Anti-Inflammatory Agents, Bone Resorption, Bone and Bones, Calcium-Binding Proteins, Cells, Cultured, Collagen, Culture Media, DNA Replication, Guanidines, Humans, Indomethacin, Interleukin-1, Mice, Monocytes, Osteocalcin, Proline, Protein Biosynthesis