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Human bone cells, maintained in culture, have been subjected to partitioning in an aqueous two-phase system on a countercurrent distribution apparatus. A broad cell distribution was obtained indicating cell-surface heterogeneity. Two major cell populations were identified which appeared to be growing at different rates. The 'fast'-growing cells had a less hydrophobic cell surface than the 'slow'-growing cells. Possible relationships of these cell populations with osteoblast differentiation and the potential importance of this technique in studies of osteoblast differentiation are discussed.

Original publication

DOI

10.1007/BF01122506

Type

Journal article

Journal

Biosci rep

Publication Date

05/1984

Volume

4

Pages

415 - 419

Keywords

Bone and Bones, Cell Differentiation, Cell Separation, Cells, Cultured, Countercurrent Distribution, Dextrans, Humans, Osteoblasts, Polyethylene Glycols