Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Partially purified human interleukin-1 (IL-1) was shown to be a potent stimulator of DNA synthesis and proliferation by cells derived from human trabecular bone. Stimulation by the factor was affected by serum concentration in the cultures, the degree of confluence of the cells, and the presence of indomethacin in the cultures. The bone cell-activating factor comigrated with IL-1 over gel filtration chromatography (M(r) 15,000 and 30,000) and isoelectric focusing (pI 5.6 and 7.1), and was active over the same concentration range in the bone cell proliferation and lymphocyte activating factor (LAF) assays. Interferon-γ (IFN-γ) was shown to completely inhibit IL-1-stimulated bone resorption at concentrations between 30 and 300 U/ml. Basal bone resorption was slightly depressed.


Journal article


British journal of rheumatology

Publication Date





147 - 149