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BACKGROUND: Postoperative scarring and radiotherapy changes in the conservatively treated breast often mimic breast cancer recurrence, resulting in many unnecessary biopsies. Local breast cancer recurrence may be detected more accurately with contrast-enhanced colour Doppler imaging. METHODS: Fifty-eight women with suspected local breast cancer recurrence were evaluated prospectively by means of conventional and contrast-enhanced colour Doppler imaging before surgical biopsy. RESULTS: Sensitivity for the detection of breast cancer recurrence using contrast enhancement was 94 per cent (specificity 67 per cent). Contrast enhancement significantly increased overall diagnostic accuracy, from 80 to 90 per cent (P < 0. 04). CONCLUSION: Contrast-enhanced colour Doppler imaging is a highly accurate method for detecting local breast cancer recurrence. Its adoption may substantially reduce biopsy rates.

Original publication




Journal article


The british journal of surgery

Publication Date





1198 - 1201


Department of Surgery, Royal Free and University College London Medical School, UK.


Humans, Carcinoma, Ductal, Breast, Carcinoma in Situ, Breast Neoplasms, Neoplasm Recurrence, Local, Image Enhancement, Ultrasonography, Doppler, Color, Biopsy, Needle, Sensitivity and Specificity, Prospective Studies, Adult, Aged, Middle Aged, Female