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We reviewed histologically the incidence and pathogenesis of the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the pseudocapsule, femoral and acetabular membranes and periprosthetic tissue at revision of 789 cases of failed total hip replacement. In 13, periprosthetic tissues were found to have deposits of CPPD crystals in areas of cartilaginous metaplasia; four also showed evidence of localised deposition of amyloid. None of the patients had a history of chondrocalcinosis in the hip or other joints. Cartilaginous metaplasia and other changes in periprosthetic tissues may predispose to the deposition of CPPD and associated localised amyloid.

Original publication

DOI

10.1302/0301-620x.81b3.9289

Type

Journal article

Journal

The journal of bone and joint surgery. british volume

Publication Date

05/1999

Volume

81

Pages

552 - 554

Addresses

Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford, UK.

Keywords

Femur, Acetabulum, Connective Tissue, Humans, Calcium Pyrophosphate, Amyloid, Arthroplasty, Replacement, Hip, Reoperation, Crystallization, Equipment Failure Analysis, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male