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Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.

Original publication




Journal article


Skeletal radiology

Publication Date





724 - 727


Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.


Fingers, Cartilage, Humans, Osteochondroma, Osteosarcoma, Melanoma, Bone Neoplasms, Soft Tissue Neoplasms, Phosphopyruvate Hydratase, Neoplasm Proteins, Antigens, Neoplasm, Diagnosis, Differential, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Biopsy, Middle Aged, Male, Melanoma-Specific Antigens, MART-1 Antigen, Biomarkers, Tumor