Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.

Type

Journal article

Journal

Skeletal radiology

Publication Date

12/2003

Volume

32

Pages

724 - 727

Addresses

Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.

Keywords

Fingers, Cartilage, Humans, Osteochondroma, Osteosarcoma, Melanoma, Bone Neoplasms, Soft Tissue Neoplasms, Phosphopyruvate Hydratase, Neoplasm Proteins, Tumor Markers, Biological, Antigens, Neoplasm, Diagnosis, Differential, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Biopsy, Middle Aged, Male, Melanoma-Specific Antigens, MART-1 Antigen