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Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.

Original publication

DOI

10.1007/s00256-003-0697-y

Type

Journal article

Journal

Skeletal Radiol

Publication Date

12/2003

Volume

32

Pages

724 - 727

Keywords

Antigens, Neoplasm, Biomarkers, Tumor, Biopsy, Bone Neoplasms, Cartilage, Diagnosis, Differential, Fingers, Humans, MART-1 Antigen, Magnetic Resonance Imaging, Male, Melanoma, Melanoma-Specific Antigens, Middle Aged, Neoplasm Proteins, Osteochondroma, Osteosarcoma, Phosphopyruvate Hydratase, Soft Tissue Neoplasms, Tomography, X-Ray Computed