Multiple loci on 8q24 associated with prostate cancer susceptibility.
Al Olama AA., Kote-Jarai Z., Giles GG., Guy M., Morrison J., Severi G., Leongamornlert DA., Tymrakiewicz M., Jhavar S., Saunders E., Hopper JL., Southey MC., Muir KR., English DR., Dearnaley DP., Ardern-Jones AT., Hall AL., O'Brien LT., Wilkinson RA., Sawyer E., Lophatananon A., UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology None., UK Prostate testing for cancer and Treatment study (ProtecT Study) Collaborators None., Horwich A., Huddart RA., Khoo VS., Parker CC., Woodhouse CJ., Thompson A., Christmas T., Ogden C., Cooper C., Donovan JL., Hamdy FC., Neal DE., Eeles RA., Easton DF.
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.