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AIM: To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone. METHODS: HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours. RESULTS: Five of the eight patients were found to be positive for HLA-DRB1*0801/3, the distribution of this allele in healthy white controls being quite low (2%). All but one of the patients possessing DRB1*080 also expressed DRB1*070. CONCLUSIONS: HLA-DRB1*080 is pre-dominant in patients with immunophenotypic HLA-DR negative giant cell tumour of bone; individuals with the genotype 070/080 are at particularly high risk of developing giant cell tumour of bone.

Original publication

DOI

10.1136/jcp.52.10.782

Type

Journal article

Journal

Journal of Clinical Pathology

Publication Date

10/1999

Volume

52

Pages

782 - 784

Addresses

Department of Clinical Biochemistry, Medical School, University of Newcastle, Newcastle upon Tyne, UK.

Keywords

Humans, Giant Cell Tumor of Bone, Bone Neoplasms, Genetic Predisposition to Disease, HLA-DR Antigens, Polymerase Chain Reaction, Genotype, Alleles