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Tumour necrosis factor alpha (TNFalpha) is likely to be involved in the pathogenesis of Wegener's granulomatosis. This paper reviews published clinical trials of the anti-TNFalpha agents etanercept and infliximab with regard to their efficacy and safety in the treatment of Wegener's granulomatosis. On the basis of the high rate of adverse events, particularly an increased incidence of cancers, the use of etanercept in the management of Wegener's granulomatosis is not justified. However, the potential role for infliximab or the as yet untested adalimumab cannot be discounted. The development of novel approaches focusing on blockade of specific molecules including TNFalpha in the treatment of Wegener's granulomatosis is awaited.

Original publication

DOI

10.1136/ard.2005.042416

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

11/2005

Volume

64 Suppl 4

Pages

iv31 - iv36

Addresses

Rheumatology Department, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK.

Keywords

Humans, Vasculitis, Tumor Necrosis Factor-alpha, Immunoglobulin G, Receptors, Tumor Necrosis Factor, Antirheumatic Agents, Antibodies, Monoclonal, Treatment Outcome, Wegener Granulomatosis