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The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of loci conferring susceptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis. Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls. A novel RA susceptibility locus at AFF3 was identified with convincing evidence for association in a combined sample cohort of 6819 RA cases and 12 650 controls [OR 1.12 95% confidence intervals (CI) 1.07-1.17, P = 2.8 x 10(-7)]. Association of two previously described loci (CTLA-4 and 4q27) with RA was also replicated (OR 0.87, 95% CI 0.82-0.94, P = 1.1 x 10(-4) and OR 0.86, 95% CI 0.79-0.94, P = 5.4 x 10(-4), respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases.

Original publication

DOI

10.1093/hmg/ddp177

Type

Journal article

Journal

Human molecular genetics

Publication Date

07/2009

Volume

18

Pages

2518 - 2522

Addresses

University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk

Keywords

YEAR Consortium, BIRAC Consortium, Humans, Arthritis, Rheumatoid, Diabetes Mellitus, Type 1, Autoimmune Diseases, Genetic Predisposition to Disease, Nuclear Proteins, Case-Control Studies, Cohort Studies, Polymorphism, Single Nucleotide, Multigene Family, Adult, Aged, Middle Aged, European Continental Ancestry Group, Female, Male, Genome-Wide Association Study