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One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro-tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno-suppression. The potential of macrophage-related anticancer therapies will be discussed in the light of this phenotype.

Type

Journal article

Journal

Frontiers in bioscience : a journal and virtual library

Publication Date

01/2007

Volume

12

Pages

4298 - 4314

Addresses

Nuffield Department of Orthopaedic Surgery, Botnar Research Centre, University of Oxford, UK.

Keywords

Macrophages, Humans, Neoplasms, Neovascularization, Pathologic, Antineoplastic Agents, Prognosis, Cell Hypoxia