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There is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to enhance susceptibility (relative risk 5-6). It is therefore possible that this locus may also affect the development of RA. Genotype frequencies at this locus, defined by a dimorphic Fok 1 restriction site, were compared in 139 healthy controls and 213 patients with classical/definite RA. In contrast with diabetes there was no increase in genotypes lacking the Fok 1 site, either in the rheumatoid group overall (125/211 compared with 86/139 controls) or in the DR4 positive rheumatoid group (76/140 compared with controls). These results indicate that the interaction between DR4 and a locus on chromosome 11p is not common to all DR4 associated autoimmune diseases.

Original publication




Journal article


Ann rheum dis

Publication Date





1250 - 1251


Amino Acid Sequence, Arthritis, Rheumatoid, Chromosomes, Human, Pair 11, Diabetes Mellitus, Type 1, Disease Susceptibility, Genes, MHC Class II, Genotype, HLA-DR4 Antigen, Humans, Molecular Sequence Data, Oligonucleotide Probes