Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The matching of donors and renal graft recipients for human leukocyte antigens A, B, and DR has been shown to exert beneficial effects on the outcome of transplantation. Until the advent of polymerase chain reaction amplification-based genotyping, the effect of HLA-DP compatibility on graft survival could not be thoroughly investigated. HLA-DP compatibility has been determined in three living-related transplants and 34 cadaveric transplants for donor-recipient pairs matched for HLA-DR and -DQ. The effect of DP mismatching on graft survival and function was assessed. No clear benefit from matching donor and recipient for HLA-DP could be discerned.

Original publication

DOI

10.1016/0198-8859(92)90045-o

Type

Journal article

Journal

Human immunology

Publication Date

01/1992

Volume

33

Pages

5 - 9

Addresses

Molecular Immunology Group, Institute of Molecular Medicine, Headington, Oxford, England.

Keywords

Humans, DNA Probes, HLA-DP Antigens, HLA-DQ Antigens, HLA-DR Antigens, Histocompatibility Testing, Kidney Transplantation, Retrospective Studies, Polymerase Chain Reaction, Histocompatibility, Graft Rejection, Base Sequence, Molecular Sequence Data, Tissue Donors