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The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia-regulated gene products and their associated pathways form the basis for the hypoxic promotion of tumourigenesis and malignant progression.

Original publication

DOI

10.1186/bcr314

Type

Journal article

Journal

Breast cancer research : BCR

Publication Date

01/2001

Volume

3

Pages

318 - 322

Addresses

ICRF Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

Keywords

Breast, Humans, Breast Neoplasms, Cell Transformation, Neoplastic, Neovascularization, Pathologic, Apoptosis, Cell Hypoxia, Oxidative Stress, Female