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Pseudoporphyria is characterized by erythema, blistering, and scarring on sun-exposed skin. Nonsteroidal antiinflammatory drugs (NSAIDs) are implicated in the etiology of this condition. In a 1-year prospective study of children attending the pediatric rheumatology clinic in Edinburgh we found a prevalence of pseudoporphyria of 10.9% in children taking NSAIDs for juvenile idiopathic arthritis. Naproxen was the most commonly implicated NSAID, independent of dosage. Blue/gray eye color was an independent risk factor for the development of pseudoporphyria. We would advise caution in prescribing naproxen in these children to prevent disfiguring facial scarring.

Original publication

DOI

10.1046/j.1525-1470.2000.01827.x

Type

Journal article

Journal

Pediatric dermatology

Publication Date

11/2000

Volume

17

Pages

480 - 483

Addresses

Department of Dermatology, Royal Infirmary of Edinburgh, and Department of Paediatric Rheumatology, Royal Hospital for Sick Children, Edinburgh, Scotland. BDeS2.excite.com

Keywords

Skin, Humans, Arthritis, Juvenile Rheumatoid, Porphyrias, Naproxen, Anti-Inflammatory Agents, Non-Steroidal, Prevalence, Risk Factors, Cohort Studies, Prospective Studies, Adolescent, Child, Child, Preschool, Female, Male