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A number of factors contribute to the pathogenesis of osteoarthritis. Genetic factors are predominant in some cases, including the syndrome of hereditary arthro-ophthalmopathy. The clinical features of the syndrome and the concept of genetic mutations in matrix components are discussed.

Original publication

DOI

10.1093/rheumatology/33.12.1175

Type

Journal article

Journal

British journal of rheumatology

Publication Date

12/1994

Volume

33

Pages

1175 - 1180

Addresses

Department of Rheumatology, Coventry and Warwickshire Hospital.

Keywords

Humans, Osteoarthritis, Eye Diseases, Syndrome, Collagen, Pedigree, Phenotype, Mutation, Adult, Aged, Family Health, Female, Male