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A number of factors contribute to the pathogenesis of osteoarthritis. Genetic factors are predominant in some cases, including the syndrome of hereditary arthro-ophthalmopathy. The clinical features of the syndrome and the concept of genetic mutations in matrix components are discussed.


Journal article


Br j rheumatol

Publication Date





1175 - 1180


Adult, Aged, Collagen, Eye Diseases, Family Health, Female, Humans, Male, Mutation, Osteoarthritis, Pedigree, Phenotype, Syndrome