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We performed a prospective, blind, controlled study on wound infection after implant surgery involving 41 procedures in patients infected with the human immunodeficiency virus (HIV) and 141 in HIV-negative patients. The patients were staged clinically and the CD4 cell count determined. Wound infection was assessed using the asepsis wound score. A risk category was allocated to account for presurgical contamination. In HIV-positive patients, with no preoperative contamination, the incidence of wound infection (3.5%) was comparable with that of the HIV-negative group (5%; p = 0.396). The CD4 cell count did not affect the incidence of infection (r = 0.16). When there was preoperative contamination, the incidence of infection in HIV-positive patients increased markedly (42%) compared with that in HIV-negative patients (11%; p = 0.084). Our results show that when no contamination has occurred implant surgery may be undertaken safely in HIV-positive patients.

Original publication

DOI

10.1302/0301-620x.84b6.12641

Type

Journal article

Journal

The Journal of bone and joint surgery. British volume

Publication Date

08/2002

Volume

84

Pages

802 - 806

Addresses

College of Medicine and Queen Elizabeth Hospital, Blantyre, Malawi.

Keywords

Humans, Wound Infection, HIV Infections, Joint Diseases, Biological Markers, CD4 Lymphocyte Count, Orthopedic Procedures, Incidence, Risk Assessment, Prospective Studies, Double-Blind Method, Prostheses and Implants, Wound Healing, Adolescent, Adult, Aged, Middle Aged, Fractures, Bone