Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Mediation analyses of randomized controlled trials can be used to investigate the mechanisms by which health interventions cause outcomes. In this article we provide a brief introduction to mediation analysis in the context of randomized controlled trials. We introduce common target effects, causal assumptions, estimation approaches, and illustrate these concepts using a published mediation analysis of the Systolic Blood Pressure Intervention Trial. Well-conducted mediation analyses of randomized trials can provide meaningful insights to guide clinical and policy decisions.

Original publication

DOI

10.1016/j.jclinepi.2021.02.014

Type

Journal article

Journal

J clin epidemiol

Publication Date

05/2021

Volume

133

Pages

161 - 164

Keywords

Mechanism, Mediation analysis, Randomised controlled trial